Clinical heterogeneity
Applicable or non-applicable: investigations of clinical heterogeneity in systematic reviews
... that clinical heterogeneity is diffi- cult to measure because of a lack of reporting, poorly described interventions and incomplete details of partici- pant ...reporting clinical hetero- ...of ...
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Investigating clinical heterogeneity in systematic reviews: a methodologic review of guidance in the literature
... Finally, we would like to note suggestions in the litera- ture concerning the utility of aggregate patient data (APD) versus individual patient data (IPD). Several resources give general recommendations regarding use of ...
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Clinical Heterogeneity in Korean Patients with Nemaline Myopathy
... common clinical expressions such as proximal limb weak- ness, reduced deep tendon reflex, and dysmorphic ...that clinical heterogeneity ranged from typical congenital, mildly affected childhood to ...
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Consensus-based recommendations for investigating clinical heterogeneity in systematic reviews
... Statistical heterogeneity in systematic reviews is gener- ally defined as variations in the estimated effect between ...statistical heterogeneity, there may still be factors that influence the size of the ...
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Consideration of Heterogeneity in a Meta-analysis of Latino Sexual Health Interventions
... of clinical heterogeneity is important because variability in individual effects due to differences in clinical characteristics is not re fl ected in pooled effect ...minimize clinical ...
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Clinical and genetic heterogeneity in Wilson disease - A review
... varied clinical heterogeneity making clinical diagnosis a difficult ...varied clinical manifestations of WD which makes diagnosis a challenging ...confirm clinical diagnosis, ...
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Meta-analysis of the association between <em>APC</em> promoter methylation and colorectal cancer
... significant heterogeneity between the studies that had investigated the association between APC promoter methylation and the risk of developing ...the clinical heterogeneity of the included studies ...
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Competing risk and heterogeneity of treatment effect in clinical trials
... simple clinical trials [33] with broad inclusion criteria, including older or com- plex patients, designed to provide results generalizable to "real-world" patients [3], have generally ignored the fact ...
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Systematic review and meta analysis of non pharmacological interventions to reduce the symptoms of mild to moderate anxiety in pregnant women
... Many domains included in the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach are assessed in the review (Guyatt et al. 2008), however an overall rating using the GRADE approach was not ...
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Meta-analysis of Cephalosporin Versus Penicillin Treatment of Group A Streptococcal Tonsillopharyngitis in Children
... possible clinical heterogeneity was performed by several stratified analyses: 1) grouping studies by decade; 2) grouping studies by individual cephalosporin generation; and 3) grouping studies by individual ...
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The clinical and genetic heterogeneity of autosomal dominant cataract
... In all the pedigrees apart firom the pulveru lent pedigrees the morphology was the same in all affected family members but varied in severity. In the pulverulent pedigrees the phenotype varied among affected individuals ...
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The effectiveness and safety of treatments used for acute diarrhea and acute gastroenteritis in children: protocol for a systematic review and network meta-analysis
... Our planned methods for this review have many strengths. First, we will implement a wide-search strategy that included published work in six different databases, as well as unpublished work. Second, we aim to report im- ...
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A Genetic Investigation of Sex Bias in the Prevalence of Attention Deficit/Hyperactivity Disorder
... current clinical practices of diagnosing ADHD are capturing a clinical phenotype that is similar at the level of common genetic risk variants in both ...of clinical heterogeneity, with ADHD ...
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Assessment of tumor heterogeneity: an emerging imaging tool for clinical practice?
... uniformity of surrounding ‘ normal ’ liver at texture ratios of 1.5/2.5 and 2.0/2.5 predicted for survival, potentially related to differences in vascularization and shunting related to the presence of metastases [43]. ...
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Multi-minicore Disease
... Regular physiotherapy is aimed at promoting endurance, preservation of muscle function and the prevention of contractures, particularly those of the tendon Achilles. Marked axial involvement is common, particularly in ...
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Gene signatures of breast cancer progression and metastasis
... for clinical use, some of which are now commercially available ...assay. Clinical evidence in hormone responsive breast cancer supports the abilities of these assays to distinguish between patients who will ...
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Translating insights into tumor evolution to clinical practice: promises and challenges
... of heterogeneity, such as copy number diversity in lung cancer [89] and pan-mutational diversity (so-called regional ‘explosions’) in childhood cancers [144], have also been shown to carry prognostic ...
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Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal
... in clinical trial ...important heterogeneity in treatment effects (HTE) across the trial population, such that the balance between treatment risks and benefits may differ substantially between large ...
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Clinical significance of monocyte heterogeneity
... human monocytes, accumulate in the myocardium imme- diately after AMI and are followed by a recovery period denoted by expansion of Ly6C low monocytes (analogous to human non-classical monocytes) [50,54]. However, ...
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Isolation of Lodderomyces elongisporus from the Catheter Tip of a Fungemia Patient in the Middle East
... In vitro susceptibility of both isolates was determined by Etest (AB Biodisk, Solna, Sweden) on RPMI medium sup- plemented with 2% glucose as recommended by Clini- cal Laboratory Standards Institute [17]. The test was ...
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