Clonal expansion
Clonal expansion of genome intact HIV 1 in functionally polarized Th1 CD4+ T cells
... with clonal expansion of CD4 + T cells harboring intact ...that clonal proliferation of Th1-polarized CD4 + T cells encoding for intact HIV-1 represents a driving force for stabilizing the pool of ...
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Long-term remission despite clonal expansion of replication-competent HIV-1 isolates
... while clonal expansion of replication-competent virus can present a barrier to viral eradication, these viral isolates remain susceptible to HIV-specific immune responses and can be controlled in patients ...
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Clonal expansion within pneumococcal serotype 6C after use of seven valent vaccine
... (MLST) clonal complex 395 ...largest clonal complex was characterised by the presence of lantibiotic synthesis ...rapid clonal expansion has occurred within a single MLST clonal ...
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Clonal Expansion during Staphylococcus aureus Infection Dynamics Reveals the Effect of Antibiotic Intervention
... in clonal expansion of a single strain ...differential clonal expansion produced cases wherein either one or two strains out of three predominated (alongside cases wherein all three strains ...
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Clonal Expansion of a Globally Disseminated Lineage of Mycobacterium tuberculosis with Low IS6110 Copy Numbers
... the clonal expansion of Mycobacterium tuberculosis and accurate identification of predominant evolutionary lineages in this species remain limited, especially with regard to low-IS6110-copy-number ...
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Clonal Expansion of Normal-Appearing Human Hepatocytes during Chronic Hepatitis B Virus Infection
... of clonal expansion in the chimpan- zee model, often considered not to develop HCC, might argue against this possibility, but in fact the risk of cirrhosis and HCC in chimpanzees is unknown, because very ...
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Clonal expansion is a characteristic feature of the B cell repertoire of patients with rheumatoid arthritis
... During normal B cell development, the processes of gene segment recombination and coding end process- ing yield nucleotide HCDR3 lengths that are characteris- tic and virtually invariant for an individual B-cell clone. ...
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rPinecone: Define sub lineages of a clonal expansion via a phylogenetic tree
... In the second example, rPinecone distinguished lineages of an S. Typhi population circulating in a defined geographi- cal area causing locally endemic disease, as opposed to a clonal outbreak. LV bacterial ...
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The role of integration and clonal expansion in HIV infection: live long and prosper
... undergo clonal expansion, and produce replication competent ...persistence, clonal expansion of the HIV reservoir, and highlight current challenges and outstanding questions for future ...
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Persistence, Replacement, and Rapid Clonal Expansion of Meningococcal Carriage Isolates in a 2008 University Student Cohort
... for clonal expansion in residential halls within universities, which has implications for the implementation of prophylactic measures following a case of meningococcal disease in this type of set- ting, ...
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HTLV 1 drives vigorous clonal expansion of infected CD8+ T cells in natural infection
... not correlate with the degree of clonal expansion (the oligoclonality index), but rather with the total number of HTLV-1-infected clones. We also found, in an analy- sis of the integration site preferences ...
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Evolution of Resistance During Clonal Expansion
... antibiotics treatment (L enski 1998; L evin et al. 2000; L evy 2001). Viral infections are treated with antiviral drugs only after an initial phase of exponential growth during which resistance mutations arise (N owak et ...
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Whole genome sequencing reveals clonal expansion of multiresistant Staphylococcus haemolyticus in European hospitals
... A total of 134 isolates of S. haemolyticusfrom geographically diverse origins (Belgium, 2; Germany, 10; Japan, 13; Norway, 54; Spain, 2; Switzerland, 43; UK, 9; and USA, 1) were sequenced (Table S1, available as ...
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Clonal expansion of lung V delta 1+ T cells in pulmonary sarcoidosis
... their clonal nature. These clonal expansions of V delta 1+ cells in pulmonary sarcoidosis provide evidence for a disease process that involves specific recognition of a local antigen by T cells, and ...
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The microevolution and epidemiology of Staphylococcus aureus colonization during atopic eczema disease flare
... Staphylococcus aureus is an opportunistic pathogen and variable component of the human microbiota. A characteristic of atopic eczema (AE) is colonization by S. aureus, with exacerbations associated with an increased ...
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Acyclic retinoid induces differentiation and apoptosis of murine hepatic stem cells
... the clonal expansion of ...the clonal expansion of HpSCs almost stopped, the colony number decreased to ...of clonal expansion, we examined the Ki-67-positive cells after ...
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High diversity of chromosomal aberrations in a Brazilian myelodysplastic syndrome cohort
... The cytogenetic analysis was performed using bone marrow samples from 32 patients with primary MDS in central Brazil. The cohort comprised 23 females and 9 males, with a mean age of 53.8 years (range 26 - 75 years) for ...
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T cell repertoire following autologous stem cell transplantation for multiple sclerosis
... following reconstitution, and patients largely developed a new repertoire. In contrast, dominant CD8 + clones were not effectively removed, and the reconstituted CD8 + T cell repertoire was created by clonal ...
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Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
... in epidermal DNA syn- thesis (M. Rodriguez-Puebla and C. Conti, personal communi- cation), while Stat3-deficient mice exhibited a more persistent downregulation of BrdU incorporation following TPA treatment. These data ...
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Plasmid-mediated mcr-1 colistin resistance in Escherichia coli and Klebsiella spp. clinical isolates from the Western Cape region of South Africa
... transferred between bacterial strains and therefore pose a massive risk to the treatment of Gram-negative infec- tions. Distribution of these plasmids amongst carba- penem resistant organisms, especially in the hospital ...
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