cns development
The impact of RASopathy-associated mutations on CNS development in mice and humans
... Several studies suggested that neurofibromin might be required for NSCs or neuroglial progenitor function, and that Nf1 mutations affect both astroglial and neuronal lin- eages. Studies using a well-characterized human ...
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Heparan Sulfate Proteoglycan Agrin in CNS Development and Aging
... with CNS development, and agrin is expressed abundantly in CNS, it is logical to speculate that agrin plays important roles in CNS ...obvious CNS phenotypes in agrin null mice is early ...
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Radial glial cells: Key organisers in CNS development
... the CNS during ...the development of the brain and spinal ...early development and can give rise to a small population of multipotent cells in neurogenic niches of the adult ...during ...
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Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development
... Clinically, the unique neuromotor findings in patients have suggested a different origin of dis- ease pathogenesis compared with the more proximal urea cycle disorders where hyperammonemia is prominent. MRI of 1 patient ...
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ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration
... ly development to adulthood, corresponding with the available amount of ...early development, while, in contrast, a tran- script ratio of approximately 50:50 may affect primarily the CNS over a ...
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In Vivo Regulation of the μ Opioid Receptor: Role of the Endogenous Opioid Agents
... during development altered the expression of the endogenous opioid propeptides proenkephalins and ...embryonic development, since pro- liferation was disorganized in the central nervous system of ...
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Morphological and behavioural variation in CNS innate defence cell microglia is development and age sensitive
... Aim: Microglia, the innate defence cells in central nervous system (CNS), alters their shapes and function with age. We observed and identified these morphological changes and functional association throughout the ...
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Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination
... embryonic CNS, development of myelin-forming oligodendrocytes is limited by bone morphogenetic proteins, which constitute one arm of the transforming growth factor- β (Tgf β ) family and signal canonically ...
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A centrosomal view of CNS growth
... to asymmetric Shh activity and neurogenic divisions (Fig. 3A). Disrupting the interaction of pericentrin with the centrosome leads to PKA mislocalization in mitosis and an increase in asymmetric neurogenic divisions ...
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Interleukin 18 in the CNS
... in CNS development suggested by work on microglial cultures from newborn mice and brain homogenates where IL-18 was preferentially expressed during early postnatal stages and subsequently downre- gulated, ...
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Slit and Robo control the development of dendrites in Drosophila CNS
... embryonic CNS with Slit (C) and Pak (D) antibodies at hour ...entire CNS, including the longitudinal connectives (lc), commissures (ac and pc) and neuronal cell bodies (cb) (D, blue on ...embryonic ...
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DNase I hypersensitivity analysis of the mouse brain and retina identifies region-specific regulatory elements
... mammalian CNS presents a significant challenge for traditional ...The development of DNase I hypersensitiv- ity mapping at the genome-wide scale has provided new approaches to characterize CRMs and the ...
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CNS resident classical DCs play a critical role in CNS autoimmune disease
... whether CNS moDCs are incompetent APCs because of reduced expression of ...that CNS cDCs expressed high levels of H2M pro- tein (Figure 3C, ...in CNS moDCs. In addition, CNS cDCs expressed ...
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Bundling arrows: improving translational CNS drug development by integrated PK/PD-metabolomics
... that CNS drug development suffers from low success rates (<10%) and long duration ...by CNS-mediated side effects ...of CNS pathol- ogy and pharmacology, and the lack of biomarkers ...
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Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models
... of development and maturation is thus recapitulated in vitro and retained upon transplantation into the mouse or rat cortex (Espuny- Camacho et ...the development, migration, integration and physiological ...
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Expression of protocadherin 18 in the CNS and pharyngeal arches of zebrafish embryos
... Analysis of sections also showed that pcdh18 was expressed in the telencephalon, medial longitudinal fascicle of the dien- cephalon, tectum, and upper rhombic lip. pcdh18 was expressed in sensory systems such as the ...
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Etiological and clinical characteristics of central diabetes insipidus in children: a single center experience
... with CNS malformations, particu- larly in those with SOD, or occurred abruptly as a result of neurosurgical intervention in patients with intracra- nial ...
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Functional analyses of a novel leucine rich repeat containing protein, Elfn1, in the mouse
... 1.3 Leucine-rich repeat proteins in nervous system development Studies have shown that there are a large number of LRR-containing proteins expressed in the central nervous system CNS, a [r] ...
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Classification of congenital abnormalities of the CNS
... As encephaloclastic schizencephaly is an acquired disease after a primarily normal neural development, signs of a migrational disorder are absent [43].... CONGENITAL ABNORMALITIES OF THE[r] ...
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Communication from the Commission to the Council and the European Parliamenton the presentation of a proposal for a directive and two proposals for recommendations on the admission of third-country nationals to carry out scientific research in the European Community. Proposal for a Council Directive on a specific procedure for admitting third-country nationals for purposes of scientific research. Proposal for a Council Recommendation to facilitate the admission of third-country nationals to carry out scientific research in the European Community. Proposal for a Council Recommendation to facilitate the issue by the Member States of uniform short-stay visas for researchers from third countries travelling within the European Community for the purpose of carrying out scientific research. COM (2004) 178 final, 16 March 2004
... the development of expatriate communities of scientific researchers working on their countries’ development in the fields of science, technology and higher ...and development on 19 May 2003, asking ...
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