co-activator
Pulikkan, John Anto (2008): Max as a novel co-activator of myeloid transcription factor C/EBPα and the critical role of PIN1 in Acute Myeloid Leukemia with C/EBPα mutation. Dissertation, LMU München: Medizinische Fakultät
... important co-activator of C/EBP a , silencing of Max should inhibit differentiation induction by ...and/or co-expressed with shRNA against Max, control shRNA, and the cells cultured in media ...
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TET1 regulates hypoxia induced epithelial mesenchymal transition by acting as a co activator
... scriptional co-activator since the catalytically inactive TET1 could rescue hypoxia-induced EMT in TET1 knockdown ...a co-repressor since Tet1 has dual functions on gene tran- scription and also ...
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Senseless physically interacts with proneural proteins and functions as a transcriptional co activator
... is co-expressed with basic helix-loop-helix (bHLH) proneural proteins in Drosophila sensory organ precursors and is required for their normal ...and co- activator functions of Senseless is the ...
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Co-activator p120 is increased by gonadotropins in the rat ovary and enhances progesterone receptor activity
... in co-activators, and are reported to be essential for exhibiting the full activity of p300 in terms of histone acetyltransferase (HAT) activ- ity ...a co-activator of most ster- oid hormone ...
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Involvement of TORC2, a CREB co activator, in the in vivo specific transcriptional control of HTLV 1
... The transcription of HTLV-1 is controlled by CREB bind- ing to the enhancer sequence, which consists of three 21- bp direct repeats containing CREs in the middle. The viral transactivator, Tax, interacts with both CREB ...
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Genetic variation of ESR1 and its co activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor positive breast cancer
... ER co-activator [34] that physically interacts with ER a and plays a role in amplifying ER sig- naling, which provides a convincing biological mechan- ism for the observed genetic interaction between the ...
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Hedgehog stimulated stem cells depend on non canonical activity of the Notch co activator Mastermind
... Normal self-renewal of follicle stem cells (FSCs) in the Drosophila ovary requires Hedgehog (Hh) signaling. Excess Hh signaling, induced by loss of patched ( ptc ), causes cell-autonomous duplication of FSCs. We have ...
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LMO4 functions as a co activator of neurogenin 2 in the developing cortex
... few co-factors have been suggested to potentiate the transcriptional activity of neurogenin (NGN) family ...a co-activator of the NGN family in cortical cells and spinal motoneurons (Sun et ...
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nemo like kinase is an essential co activator of Wnt signaling during early zebrafish development
... upon co-injection of wnt8 ORF1 MO ...as co-injection of nlk MO does not enhance the mild cyclopia induced by injection of low doses of strabismus/trilobite MO ...
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Foxa2 acts as a co activator potentiating expression of the Nurr1 induced DA phenotype via epigenetic regulation
... epigenetic activator of DA gene expression regardless of developmental ...epigenetic activator to initially recruit Foxa2 to specific DA gene ...and co-activators to interact (Adams and Workman, ...
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Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor
... AR co-localize and interact, resulting in deubiquitination of AR. Co-localization of AR and Usp12 occurs in the cytoplasm which can be explained by the large portion of the proteasome being present in the ...
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Transcriptional co-activator TAZ sustains proliferation and tumorigenicity of neuroblastoma by targeting CTGF and PDGF-β
... In our study, we demonstrate that TAZ promotes cell proliferation and colony formation in neuroblastoma cells through the induction of PDGF-β based on the following observations: i Overe[r] ...
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Mastermind like transcriptional co activator mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity
... (Fig. 11E). ChIP assays with NIH3T3 cells verified that RBP-J could directly bind to the Klf4 promoter in vitro (Fig. 11F). Luciferase assays using HEK293 cells showed that transfection of mN1-ICD cDNA enhanced mKlf4 ...
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Reduced glutathione as a physiological co activator in the activation of peptidylarginine deiminase
... Circulating proteins produced outside joints (e.g. fibrinogen produced in the liver) are present in a citrullinated form in SF from RA patients [28, 29], suggesting that extracellular citrullination occurs within the ...
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Roles of transcriptional factor 7 in production of inflammatory factors for lung diseases
... IL-17, which is an important cytokine involved in infec- tion, autoimmune response and allergy, is mainly pro- duced by Th17 cells to promote the formation of Th17 cells [60]. A special link between IL-17 and asthma has ...
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Design, Synthesis and Conformational Analyses of Bifacial Benzamide Based Foldamers
... co-activator sequence. The match was assessed on the basis of the RM“D -carbons on the helix and oxygen atoms on the foldamer together with an evlauation on the quality of orientation with respect to the ...
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Huntington's Disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database
... In addition to hyperphosphory- lated tau, a decrease in nuclear ß-catenin (a transcrip- tional co-activator whose turnover is regulated by GSK- 3ß phosphorylation) has been observed in t[r] ...
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Regulation of myoglobin expression
... transcriptional co-activator, peroxisome-proliferator-activated receptor- g co-activator-1 (PGC-1 ), also serves a significant role in modulating myoglobin gene transcription (Lin et ...
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Meis2 competes with the Groucho co repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain hindbrain boundary organizer
... Groucho co-repressor Tle4 (Grg4) for binding to Otx2 and thereby restores Otx2 transcriptional activator ...a co-repressor and a co- activator, which compete for binding to Otx2 in the ...
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<p>Silencing of TAZ inhibits the motility of hepatocellular carcinoma cells through autophagy induction</p>
... transcriptional co-activator with PDZ-binding motif (TAZ), also known as WW domain containing tran- scription regulator 1, is one of the Hippo downstream effectors responsible for mediating the vast ...
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