Co-receptor
Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India
... the co-receptor usage on the basis of the V3 ...a co- receptor (R5/X4 or X4 variants) or not (R5 variants) [10], (ii) the distant segments (ds)Kernel which include relative positional ...
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A combinatorial TIR1/AFB–Aux/IAA co receptor system for differential sensing of auxin
... auxin co-receptor complex consisting of TIR1 and an Aux/IAA ...form co-receptor complexes with a wide range of auxin-binding ...many co-receptors with distinct auxin sensing ...
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HIV 1 envelope, integrins and co receptor use in mucosal transmission of HIV
... chemokine receptor, usually CCR5 or ...The receptor switch occurs in ~ 40% of the infected individuals and is associated with faster disease ...of co-receptor usage; however, there is no ...
10
The Drosophila Ret gene functions in the stomatogastric nervous system with the Maverick TGFβ ligand and the Gfrl co receptor
... RET receptor tyrosine kinase is crucial for the development of the enteric nervous system (ENS), acting as a receptor for Glial cell line-derived neurotrophic factor (GDNF) via GFR ...Gfr-like ...
12
Bioinformatics Analysis of the FREM1 Gene—Evolutionary Development of the IL-1R1 Co-Receptor, TILRR
... IL-1 receptor (TIR) family, characterized by the cytoplasmic TIR domain ...and co-receptor association, a potent regulator of signal amplification at the level of the receptor complex, are ...
11
Characterization of cervical cancer stem cell-like cells: phenotyping, stemness, and human papilloma virus co-receptor expression
... The first contact between HPV and the host cell is initiated by heparan sulfates and glycosaminoglycans. On the surface, after HPV interaction with CD49f (an alpha-integrin), a subsequent HPV Annexin II ...
12
T4 lysozyme-engineered human chemokine receptor ccr5 mutants exhibit differing effects on hiv-1 co-receptor function and ligand binding
... HIV-1 co-receptor function, and recombinant T4L-CCR5 variant proteins show blocking effects in a CCL4-induced migration ...(A) Co-receptor activities of T4l-CCR5 variants relative to that of ...
11
Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor.
... a co-activator protein (either Cdc20 or Cdh1) together with core APC/C subunits 1 , 2 , the structural basis for substrate recognition and ubiquitylation is not ...a co-receptor for D-box following ...
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Reduced expression of the Nodal co receptor Oep causes loss of mesendodermal competence in zebrafish
... Nodal co-receptors from the EGF-CFC family (Cheng et ...Nodal co-receptor One- eyed pinhead (Oep; also known as Tdgf1) is essential to mediate the interaction between Nodal ligand and receptor ...
6
The co receptor signaling model of HIV 1 pathogenesis in peripheral CD4 T cells
... the co-receptor usage, from CCR5 to CXCR4, at late stages of ...The co-receptor signaling model of HIV pathogenesis in peripheral CD4 T ...
6
Structure of HIV-1 quasi-species as early indicator for switches of co-receptor tropism
... The dynamics of the quasi-species in the probabilities plane has several remarkable features. First, all sequences in week 0 cluster in the lower left corner of the plane as is expected for a quasi-species that is R5 ...
5
Defining the fitness of HIV-1 isolates with dual/mixed co-receptor usage
... cells, co-receptor expression on susceptible cell subsets, differential immune response to x4 and r5 viruses, and preferential transmission of r5 variants followed by a slow evolution to x4 ...
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Defining binding efficiency and specificity of auxins for SCFTIR1/AFB Aux/IAA co receptor complex formation
... using a molecular harness coupled with similarity indices o ff ered additional theoretical and experimental insights. 27 The earlier work assumed activity was associated with activation of a single receptor. The ...
11
Co receptor CD8 mediated modulation of T cell receptor functional sensitivity and epitope recognition degeneracy
... the co-receptor and a specific subset of its potential agonists “comes into ...costimulatory receptor- mediated signals transmitted by professional APCs ...
12
A simple structure-based model for the prediction of HIV-1 co-receptor tropism
... for co-receptor tropism ...in co-receptor tropism. The most simple and best-known model of co-receptor usage is the 11/25 rule [6] predicting a virus to be R5-tropic unless one ...
11
The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor
... FGF receptor ligand system could change due to the concentration of FGF-2, particularly since there is evidence for FGF-2 possessing two binding sites for the FGFR of different affinities [24] and three binding ...
10
HIV 1 co receptor usage:influence on mother to child transmission and pediatric infection
... CCR2 receptor (CCR2-64I) showed contradicting results when analyzed in relation to MTCT [64,65] but exerted a protective effect on disease progression in perinatally infected chil- dren ...chemokine ...
10
TILRR, a novel IL 1RI co receptor, potentiates MyD88 recruitment to control ras dependent amplification of NF ?B
... IL-1 receptor complex and magnifies signal amplification by increasing receptor expression and ligand ...IL-1RI co-receptor, which associates with the signaling receptor complex to ...
12
CD109, a TGF β co receptor, attenuates extracellular matrix production in scleroderma skin fibroblasts
... II receptor, which then recruits and phosphory- lates the TGF- b type I receptor resulting in activation of TGF- b type I receptor kinase activity ...I receptor propagates the signal by ...
12
Distribution of the mutated delta 32 allele of CCR5 co-receptor gene in Iranian population
... protective effect in HIV infection (13). The aim of this study was to determine the ∆32 allele frequency in healthy individ- uals and HIV-infected individuals with AIDS. The present study explored the ef- fect of the ...
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