cob(II)alamin
Cobalamin deficiency resulting in a rare haematological disorder: a case report
... Diagnosing cobalamin deficiency is straightforward when the deficiency is ...derline cobalamin level. Classically, the diagnosis is based on a low cobalamin level, but elevated MMA and Hcys levels ...
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Cobalamin F Disease Detected by Newborn Screening and Follow-up on a 14-Year-Old Patient
... The use of tandem mass spectrometry (MS/MS) for newborn screening (NBS) enables presymptomatic detection of many inborn errors of metabolism including conditions that result in methylmalonic acidemia. In this con- ...
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Inhibition of cobalamin dependent enzymes by cobalamin analogues in rats
... the cobalamin (cbl) molecule are required for enzyme activity and which parts, if altered, might inhibit cbl-dependent enzyme activity, we synthesized 16 cbl analogues and administered them to nutritionally normal ...
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Cobalamin C Defect Presenting With Isolated Pulmonary Hypertension
... of Cobalamin C defect, reviewed and revised the article, and approved the fi nal article as submitted; Dr Monti supervised the radiological images, reviewed and revised the article, and approved the fi nal article ...
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Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring
... take cobalamin supplements throughout the entire ...taking cobalamin-containing supplements on a regular basis from 20 wk of pregnancy, and 24 women took supplements from 32 ...of cobalamin for these ...
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Presence and formation of cobalamin analogues in multivitamin mineral pills
... harmful cobalamin analogues by multivitamin-mineral interactions and that these interactions may be responsible for the presence of cobalamin analogues in animal chows and animal and human blood and ...
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Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin dependent enzymes in rats
... In man, use of the general anesthetic nitrous oxide, N2O, is associated with hematologic and neurologic abnormalities that mimic those seen in cobalamin (Cbl, vitamin B12) deficiency. We have measured a number of ...
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Concerning the Biosynthesis of Sirohaem in Bacillus megaterium: The Relationship with Cobalamin Metabolism
... Most cobalamin-dependent reactions are known to be rearrangements between a hydrogen atom and another group on an adjacent carbon atom in the same substrate ...of cobalamin in reactions such as this is the ...
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Correction of Cobalamin Malabsorption in Pancreatic Insufficiency with a Cobalamin Analogue that Binds with High Affinity to R Protein but not to Intrinsic Factor: IN VIVO EVIDENCE THAT A FAILURE TO PARTIALLY DEGRADE R PROTEIN IS RESPONSIBLE FOR COBALAMIN MALABSORPTION IN PANCREATIC INSUFFICIENCY
... In vitro studies indicate that [ 57 Co]cobalamin (Cbl) is preferentially bound to salivary R protein as opposed to intrinsic factor (IF) and that [ 57 Co]Cbl bound to R protein is not transferred to IF at either ...
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Guidelines for the diagnosis and treatment of Cobalamin and Folate disorders
... serum cobalamin level, although it has been proposed that a serum cobalamin of less than 200 ng/L (148 pmol/L) would have a sensitivity of diagnosing 97% of true cobalamin deficiency(Carmel and ...
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A CLINICAL STUDY ON THE MANAGEMENT OF VITAMIN B12 (COBALAMIN) DEFICIENCY POLYNEUROPATHY WITH AMALAKI RASAYANA
... Eighty percent of cobalamin is stored in liver, which is further transported to tissues. Inflammation and oxidative stress contribute to liver injury & amalaki which is rich in vitamin C, gallic acid, ...
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Cobalamin inactivation decreases purine and methionine synthesis in cultured lymphoblasts
... methionine is the immediate precursor of S-adenosylmethionine, a potent inhibitor of 5- methyltetrahydrofolate synthesis; methionine serves as a source of formate for purine synthesis; and rates of purine synthesis are ...
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Iron Profile in Cobalamin Deficiency: a prospective single centre based study
... 4. Atrah HI, Davidson RJL (1988) Iron deficiency in pernicious anaemia: a neglected diagnosis. Postgrad Med J 64:110-111] 5. Remacha AF, Sarda` MP, Canals C, Queralto` JM et al (2013) Combined cobalamin and iron ...
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Grützner, Niels (2011): Genetische Studie zum Cobalamin-Mangel beim Chinesischen Shar-Pei. Dissertation, LMU München: Tierärztliche Fakultät
... For each microsatellite marker, the most frequent allele in the group of Shar Peis with an undetectable serum cobalamin concentration was identified, and was compared to the frequency in Shar Peis with a serum ...
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Absorption, Plasma Transport, and Cellular Retention of Cobalamin Analogues in the Rabbit: EVIDENCE FOR THE EXISTENCE OF MULTIPLE MECHANISMS THAT PREVENT THE ABSORPTION AND TISSUE DISSEMINATION OF NATURALLY OCCURRING COBALAMIN ANALOGUES
... of cobalamin (Cbl; vitamin B 12 ) are prevalent in nature as a result of bacterial synthesis, and are of additional interest because of their potential use as antimetabolites and chemotherapeutic ...
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Cobalamin malabsorption due to nondegradation of R proteins in the human intestine Inhibited cobalamin absorption in exocrine pancreatic dysfunction
... administration of cyano[57Co]cobalamin preparations. Immunochemical analysis of the aspirates demonstrated that all isotopic vitamin was transferred to a protein that is identical to the gastric intrinsic factor ...
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Relationship between cobalamin deficiency and delirium in elderly patients undergoing cardiac surgery
... postoperative cobalamin levels were not ...with cobalamin deficiency undergoing other types of cardiac surgery are at increased risk for delirium warrants further ...
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Hereditary Transcobalamin II Deficiency with Subnormal Serum Cobalamin Levels
... The effect of the patient’s serum on cobalamin- binding proteins was tested by incubating various sera, labeled with cobalt-57 (57Co)-cyanocobalamin, with her serum for one hour at room [r] ...
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Cobalamin and folate status in malnourished children
... of cobalamin or folate deficiency has traditionally depended on the recognition of the relevant abnormalities in the peripheral blood and analysis of the blood levels of the ...to cobalamin deficiency, the ...
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Cobalamin Binding and Cobalamin Dependent Enzyme Activity in Normal and Mutant Human Fibroblasts
... Co]- cobalamin binding exhibited by both cbl C and cbl D fibroblasts is almost certainly not a result of mutations which affect the methyltransferase or mutase apoenzymes, since the electrophoretic mobilities and ...
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