coenzyme-A
Engineering Acetyl Coenzyme A Supply: Functional Expression of a Bacterial Pyruvate Dehydrogenase Complex in the Cytosol of Saccharomyces cerevisiae
... acetyl coenzyme A (acetyl-CoA) is a key precursor for biosynthesis in eukaryotes and for many industrially relevant product pathways that have been introduced into Saccharomyces cerevisiae, such as isoprenoids or ...
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Pyrophosphate Dependent ATP Formation from Acetyl Coenzyme A in Syntrophus aciditrophicus, a New Twist on ATP Formation
... ABSTRACT Syntrophus aciditrophicus is a model syntrophic bacterium that degrades key intermediates in anaerobic decompo- sition, such as benzoate, cyclohexane-1-carboxylate, and certain fatty acids, to acetate when grown ...
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Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages
... Results: Phenotypic screening of a small library (32 kinase-inhibitor analogs) against Plasmodium falciparum NF54-luc asexual erythrocytic stage parasites identified a diarylthioether structurally unrelated to registered ...
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The 3 hydroxy 3 methylglutaryl coenzyme A (HMG CoA) reductases
... type coenzyme-binding site (a three-dimensional structural fold that contains a nucleotide-binding motif and is found in many enzymes that use the dinucleotides NADH and NADPH for ...of coenzyme A by the ...
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Cofactor Selectivity in Methylmalonyl Coenzyme A Mutase, a Model Cobamide Dependent Enzyme
... The effect of lower ligand structure on the biochemistry of cobamide-dependent enzymes has been studied to a limited extent. In “base-on” enzymes, the lower ligand base coordinates the central cobalt ion of the cobamide, ...
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Improving Production of Malonyl Coenzyme A Derived Metabolites by Abolishing Snf1 Dependent Regulation of Acc1
... Acetyl coenzyme A (acetyl-CoA) carboxylase (ACCase) plays a central role in carbon metabolism and has been the site of action for the development of therapeutics or herbicides, as its product, malonyl-CoA, is a ...
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Purification of human very long chain acyl coenzyme A dehydrogenase and characterization of its deficiency in seven patients
... acyl- coenzyme A dehydrogenation activities, overall palmitic acid oxidation, and VLCAD protein synthesis using pulse-chase, further confirming the diagnosis of VLCAD ...
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Covalent Aurora A regulation by the metabolic integrator coenzyme A
... In a clinical context, overexpression of Aurora A is frequently de- tected in human malignancies, including leukemia, breast, prostate and colon cancers [18,36,37], and lower overall survival in patients with colorectal ...
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Recruitment of PI4KIIIβ to Coxsackievirus B3 Replication Organelles Is Independent of ACBD3, GBF1, and Arf1
... Members of the Enterovirus (poliovirus [PV], coxsackieviruses, and human rhinoviruses) and Kobuvirus (Aichi virus) genera in the Picornaviridae family rely on PI4KIII  (phosphatidylinositol-4-kinase III  ) for ...
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The multiple acyl coenzyme A dehydrogenation disorders, glutaric aciduria type II and ethylmalonic adipic aciduria Mitochondrial fatty acid oxidation, acyl coenzyme A dehydrogenase, and electron transfer flavoprotein activities in fibroblasts
... The multiple acyl-coenzyme A (CoA) dehydrogenation disorders (MAD) include severe (S) and mild (M) variants, glutaric aciduria type II (MAD:S) and ethylmalonic-adipic aciduria (MAD:M). Intact MAD:M mitochondria ...
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Purification and Characterization of Glucose 6 Phosphate Dehydrogenase from Pigeon Pea (Cajanus cajan) Seeds
... rocyte (0.28 U/ml) [39], turkey erythrocyte (0.5 U/ml) [36] and rainbow trout erythrocyte (1.352 U/ml) [37]. The pigeon pea glucose-6-phosphate dehydrogenase shows absolute specificity towards coenzyme NADP + , ...
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The Golgi Protein ACBD3, an Interactor for Poliovirus Protein 3A, Modulates Poliovirus Replication
... Aichi virus (AiV), another member of the Picornaviridae fam- ily, which belongs to the genus Kobuvirus and has been implicated in oyster-associated acute gastroenteritis (29), uses a different strategy to recruit ...
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Nourishing and health benefits of coenzyme Q10
... With tocopherol, ubiquinol acts as an antioxidant to stem lipid peroxidation in the inner mitochon- drial membrane (Kagan et al. 1990; Forsmark- Andree et al. 1995; Lass & Sohal 1998; James et al. 2004). Ubiquinol ...
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Complementation analysis of fatty acid oxidation disorders
... We assayed [9,10(n)-3H]palmitate oxidation by fibroblast monolayers from patients with fatty acid oxidation disorders. Activities in the different disorders were (percent control): short- chain acyl-coenzyme A ...
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L carnitine therapy in isovaleric acidemia
... Isovaleric acidemia, resulting from isovaleryl-coenzyme A dehydrogenase deficiency, is associated with marked reduction of free carnitine in both plasma and urine. Fast atom bombardment-mass spectrometry, ...
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ADCK4 “reenergizes” nephrotic syndrome
... lower coenzyme Q 10 levels, and coenzyme Q 10 supplementation ameliorated renal disease in a patient with this particular mutation, suggesting a potential therapy for patients with steroid- resistant ...
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