cohesin complex
Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer
... the cohesin complex, is among the most commonly mutated genes across multiple cancer types (25, ...core complex of cohesin consists of 2 ATPase proteins (SMC1, SMC3), a “bridge” protein, and ...
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The cohesin complex: sequence homologies, interaction networks and shared motifs
... the cohesin complex - Scc1, Scc3, Smc3 - shared this common upstream motif, along with Eco1, Pds1 and Spc24 (a protein not directly associated with the cohesin ...
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Cohesin mutations in myeloid malignancies: underlying mechanisms
... the cohesin complex emerged in AML ...the cohesin complex are strongly associated with AML, and furthermore, that cohe- sin mutations are also found at high frequency in other related myeloid ...
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Cell Cycle Control of Kaposi's Sarcoma-Associated Herpesvirus Latency Transcription by CTCF-Cohesin Interactions
... CTCF binding sites are required to suppress K14-ORF74 transcription. To further examine the functional role of CTCF binding sites at the KSHV latency control region, we assayed the effects of CTCF deletion or ...
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Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders
... the cohesin complex as well as CTCF as significant proximal interacting ...repressive complex 1 (PRC1) [69] involved in the transition from a polycomb-repressed to active chromatin state dur- ing ES ...
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Cohesin dependent regulation of Runx genes
... with highly abnormal spindles (Fig. 7B,C). Condensed chromosomes were spread throughout these cells with clumping at the poles (see also Fig. 2H,J). These observations were reiterated in rad21 morphants (Fig. 7D). Our ...
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Genetic basis of cohesinopathies
... conserved cohesin complex. The canonical cohesin complex consists of four subunits known as SMC1 and SMC3 (from the structural maintenance of chromosomes family) and SCC1 and SCC3 (sister ...
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Cohesin is required for expression of the estrogen receptor-alpha ( ESR1 ) gene
... for cohesin components in controlling ERα-regulated gene tran- scription ...Although cohesin likely plays a direct role in ERα-directed transcription, the finding that the expression of the ESR1 gene itself ...
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Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases
... condensin complex is essential for these ...condensin complex could account for a considerable degree of condensation, studies in Drosophila indicate that other activities are also ...the cohesin ...
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Irr1/Scc3 cohesin interacts with Rec8 in meiotic prophase of Saccharomyces cerevisiae
... The meiotic cohesin complex of S. cerevisiae shares with the mitotic one the Irr1/Scc3, Smc1, and Smc3 subunits, while the meiosis-specific subunit Rec8 re- places mitotic subunit Scc1/Mcd1. We noticed ...
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Identification of novel modifiers of chromosome inheritance: using a genetically sensitised drosophila model
... of cohesin subunits and cohesin regulators has been conclusively demonstrated to perturb normal chromosome cohesion and ...segregation. Cohesin not only has a central role in maintaining cohesion ...
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Cohesin loading factor Nipbl localizes to chromosome axes during mammalian meiotic prophase
... with cohesin. This suggests that the cohesin loading activity is maintained during early stages of meiotic prophase in ...the cohesin complex containing Rad21 replaces that containing ...the ...
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The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing
... of cohesin-binding sites rep- resent transcriptional enhancers [2, ...of cohesin core subunits by RNA interferences (RNAi) in ESCs causes differentiation secondary to either transcrip- tional or cell-cycle ...
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Disruption of Th2a and Th2b genes causes defects in spermatogenesis
... synaptonemal complex and cohesin are released from chromosomes before metaphase ...the cohesin complex, and SCP3, still remained and colocalized in a significant number of mutant ...
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Enhanced RAD21 cohesin expression confers poor prognosis in BRCA2 and BRCAX, but not BRCA1 familial breast cancers
... Of the four proteins that compose the core cohesin complex, RAD21 has emerged as a key marker of tumor behavior. A meta-analysis of gene-expression data from clinical cancer specimens showed that increased ...
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Enhanced expression of cohesin loading factor NIPBL confers poor prognosis and chemotherapy resistance in non small cell lung cancer
... the cohesin complex in NIPBL knockdown H1299 cell lines, we noted that cohesin core compo- nents RAD21 and SMC1A showed similar downregula- tion that was directly correlated with the level of NIPBL ...
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The Smc complexes in DNA damage response
... Smc5/6 complex and stalled replication forks A second function of the Smc5/6 complex in DNA repair is the repair of collapsed replication forks ...Smc5/6 complex is required for loading RPA and Rad52 ...
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Mec1 Dependent Phosphorylation of the Scc3 Subunit of Cohesin during Mitosis in Budding Yeast
... the cohesin dissociation pathway during prophase and prometaphase ...of cohesin to DNA damage is on its Scc1/Mcd1 subunit [11], while in humans, in case of DNA damage, phos- phorylation occurs on Smc1 and ...
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Lawrimore_unc_0153D_17951.pdf
... Condensin is a DNA-based motor protein with the ability to translocate along double-stranded DNA at relatively high velocities (60 bp/sec) (Terekawa et al., 2017). To simulate condensin tracking DNA we used the array of ...
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Griese, Julia Johanna (2010): Structures and DNA-Binding Activities of the Hinge Domains from the Structural Maintenance of Chromosomes Proteins of Pyrococcus furiosus and the Mouse Condensin Complex. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... SMC complex only after it has been loaded onto DNA, it might thus inhibit dissociation of the complex from ...yeast cohesin and the bacterial MukEF complex, however, stimulate the ATPase ...
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