Coiled coil
Balance between Coiled Coil Stability and Dynamics Regulates Activity of BvgS Sensor Kinase in Bordetella
... The enzymatic moiety of BvgS harbors the same DHp and CA domains as those of canonical TCS sensor kinases, but in many other aspects, BvgS differs from the latter (8). First, instead of extracytoplasmic PAS-like PDC ...
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Oligomerization of Hantavirus Nucleocapsid Protein: Analysis of the N-Terminal Coiled-Coil Domain
... antiparallel coiled- coil, and only at high concentrations did it assemble dimers and/or ...the coiled-coils might be important for the N-protein trimerization (as model A suggests) is in agreement ...
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Influence of Membrane-Fusogen Distance on the Secondary Structure of Fusogenic Coiled Coil Peptides
... between coiled coil formation with peptide E and membrane ...K coiled coils lack the amphipathic nature needed for strong membrane interaction and E was found to squeeze out at moderate surface ...
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De novo coiled-coil peptides as scaffolds for disrupting protein–protein interactions
... of coiled-coil assembly has led to sequence-to-structure relationships and computational methods to facilitate the reliable de novo design of a wide variety of coiled ...
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Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope
... tant coiled-coil contact mediated by a conserved leucine ...core coiled-coil, and thereby allow the adja- cent leucine residue to dock more effectively with the coiled ...the ...
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Coiled-coil mediated liposomal fusion: Asymmetric behaving peptide fusogens
... tijdelijke coiled-coil formatie vormen met peptide K, maar omdat de membraan geïncorporeerde toestand van K energetisch iets gunstiger is dan coiled-coil vorming met peptide E, is er een ...
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Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis
... Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the process of generating ...
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The Core of the Respiratory Syncytial Virus Fusion Protein Is a Trimeric Coiled Coil
... trimeric coiled-coil HR1 surrounded by helical HR2 is signif- icantly shorter than has been observed for equivalent proteins in other viruses or additional constraints provided by other parts of the protein ...
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Membrane-Fusogen Distance Is Critical for Efficient Coiled-Coil-Peptide-Mediated Liposome Fusion
... SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor) proteins are a well conserved class of fusion proteins that are primarily involved in vesicle tra ffi cking and fusion. 1−3 Complementary ...
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The Coiled-Coil Domain of the Adenovirus Type 5 Protein IX Is Dispensable for Capsid Incorporation and Thermostability
... proteins pIX ⌬ 18-44 and pIX ⌬ 60-72 associated with pIX.MYC, demonstrating that neither the conserved N-terminal domain nor the alanine stretch is involved in pIX self-association. The latter observation is contrary to ...
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Selective coordination of three transition metal ions within a coiled-coil peptide scaffold
... Designing peptides that fold and assemble in response to metal ions tests our understanding of how peptide folding and metal binding in fl uence one another. Here, histidine residues are introduced into the hydrophobic ...
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Structure, dynamics, and properties of artificial protein hydrogels assembled through coiled-coil domains
... of coiled-coil domains found widely in nature, and play critical roles in functions ranging from muscle contraction 19 to transcriptional control 20 .... Coiled-coils are characterized by heptad ...
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Cardiomyopathy mutations in the tail of beta cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes.
... Molecular basis of effects of tail mutations - All of the mutations we studied affected the helical content and coiled coil formation of 7H peptides. Three mutations, N1327K, E1356K and E1555K, which ...
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Recombination directionality factor gp3 binds ϕC31 integrase via the zinc domain, potentially affecting the trajectory of the coiled-coil motif
... the coiled-coil motif, Int457–523, was inactive in the in vivo recombination assays, which contrasts with the ability of an LI integrase lacking the CC motif to mediate intramolecu- lar attP × attB and attL ...
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The Specificity of TRIM5α-Mediated Restriction Is Influenced by Its Coiled-Coil Domain
... the coiled-coil alter the avidity of TRIM5 ␣ for the capsid by influencing the orientation and/or the spacing of the two PRYSPRY domains within a ...one coiled-coil region for another in our ...
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Extending the self-assembly of coiled-coil hybrids
... LPE/LPK coiled-coil complex is sufficient to overcome the energy barrier that keeps undecorated liposomes apart and also results in at least hemifusion ...
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Functional Importance of the Coiled-Coil of the Ebola Virus Glycoprotein
... three-stranded coiled-coil by the spring-loaded mechanism, and the C-terminal end of HA2 refolds to form a loop and to pack against the N-terminal helix in an antiparallel orientation (fusion-active state) ...
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Structural Plasticity of the Coiled-Coil Domain of Rotavirus NSP4
... form coiled-coil oligomeric ...that coiled-coil domains are one of the common features im- plicated in a wide range of functions, including ion channels and protein-protein interactions, the ...
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Mcp4, a Meiotic Coiled-Coil Protein, Plays a Role in F-Actin Positioning during Schizosaccharomyces pombe Meiosis
... expression is meiosis specific (Fig. 2A, top panels). During meiosis (Fig. 2A, remaining panels), the Mcp4-3HA signals first appeared faintly in the cytoplasm at the horsetail phase. At metaphase I, these signals ...
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The role of the Cronobacter sakazakii ProP C-terminal coiled coil domain in osmotolerance
... helical coiled coil structure [6], similar to the coiled coil structure of ProP1 (illustrated in Figure ...helical coiled coil, were acti- vated at a lower osmolality than ...
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