Colistin Resistance
Dissecting Colistin Resistance Mechanisms in Extensively Drug Resistant Acinetobacter baumannii Clinical Isolates
... antibiotic resistance rates is a major and global threat for our health care ...system. Colistin represents one of our last-resort antibiotics that is still active against most Gram-negative bacterial ...
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Plasmid-mediated mcr-1 colistin resistance in Escherichia coli and Klebsiella spp. clinical isolates from the Western Cape region of South Africa
... for colistin MIC determination, after evaluating its use on a collection of isolates with and without known colistin resistance mechanisms ...testing colistin and that disk and agar gradient ...
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Genome sequences of two clinical Escherichia coli isolates harboring the novel colistin-resistance gene variants mcr-1.26 and mcr-1.27
... group B1 is known to mainly comprise environmental and animal isolates, whereas phylogenetic group D is known to include more (urogenital-) pathogenic E. coli [24]. This result seems to be concordant with MLST, since E. ...
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Novel Plasmid Mediated Colistin Resistance Gene mcr 3 in Escherichia coli
... mobile colistin resistance gene mcr-1 has attracted global atten- tion, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by ...
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Identification of Novel Mobilized Colistin Resistance Gene mcr 9 in a Multidrug Resistant, Colistin Susceptible Salmonella enterica Serotype Typhimurium Isolate
... mobilized colistin resistance gene mcr-9 (in blue) and all previously described mcr genes (mcr-1 to -8 [in ...(B) Colistin killing assay of ...phase. Colistin was added at concentrations of 0, ...
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A Novel Phenotypic Method To Screen for Plasmid Mediated Colistin Resistance among Enterobacteriales
... of colistin as a last-resort therapy (1). Colistin is a polycationic antimicrobial that disrupts the outer membrane of Gram-negative bacteria by binding to negatively charged lipid polysaccharides (LPS) of ...
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Multicenter prospective study on the prevalence of colistin resistance in <em>Escherichia coli</em>: relevance of <em>mcr-1</em>-positive clinical isolates in Lombardy, Northern Italy
... on colistin resistance are overall ...plasmid-mediated resistance to colistin among clinical isolates of ...that resistance to colistin in ...outpatients, resistance to ...
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<p>Molecular mechanisms related to colistin resistance in Enterobacteriaceae</p>
... inactivates colistin. 10 Colistin is a polycationic antibiotic, and has signi fi cant activity against Gram negative bacteria, such as ...for colistin. When colistin binds to ...
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Structure of the catalytic domain of the colistin resistance enzyme MCR-1
... Very recently, a plasmid-encoded LPS-modifying en- zyme, named MCR-1, that provides colistin resistance has been reported from Enterobacteriaceae in China [11]. This is an additional source of concern since ...
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Prevalence and molecular characteristics of <em>mcr-1</em> colistin resistance in <em>Escherichia coli</em>: isolates of clinical infection from a Chinese University Hospital
... the colistin-resistant issue has gained worldwide ...underlying colistin resistance stated that the bacterial chromosome coding of the binary regulatory system pmr AB and pho PQ and the associated ...
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Rapid Increase in Prevalence of Carbapenem Resistant Enterobacteriaceae (CRE) and Emergence of Colistin Resistance Gene mcr 1 in CRE in a Hospital in Henan, China
... In China, the incidence of CRE infections has been increasing (8, 9). At the present, the majority of these infections occur in patients receiving significant medical care in hospitals and other health care facilities ...
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The Birth and Demise of the ISApl1 mcr 1 ISApl1 Composite Transposon: the Vehicle for Transferable Colistin Resistance
... ABSTRACT The origin and mobilization of the ~2,609-bp DNA segment containing the mobile colistin resistance gene mcr-1 continue to be sources of uncertainty, but recent evidence suggests that the gene ...
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Prevalence and molecular determinants of colistin resistance among commensal Enterobacteriaceae isolated from poultry in northwest of Iran
... acquired colistin resistance In order to analyze the molecular mechanisms account- ing for colistin-resistance in the studied commensal enteric bacteria the presence of mcr-1, 2, 3, 4 genes ...
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Deciphering MCR 2 Colistin Resistance
... confers resistance to colistin (19), although it seems unusual that the mcr-2 gene is detected only in Belgium and nowhere else ...of colistin resistance ...MCR-2 colistin ...
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Rapid detection of colistin resistance protein MCR-1 by LC–MS/MS
... In conclusion, we have demonstrated the feasibility of rapid detection of peptide markers of the MCR-1 protein in clinical isolates using LC–MS/MS, without lengthy sample processing. Total assay time from isolate to ...
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Carriage of colistin-resistant, extended-spectrum β-lactamase-producing<em> Escherichia coli</em> harboring the <em>mcr-1</em> resistance gene after short-term international travel to Vietnam
... of colistin-resistant MDR bacteria represents a worldwide threat owing to the limited number of effective antibiotics for ...mobile colistin-resistant gene mcr-1 suggests the possibility of the rapid ...
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Plasmid mediated colistin resistant mcr-1 and co-existence of OXA-48 among Escherichia coli from clinical and poultry isolates: first report from Nepal
... of colistin was determined by agar dilution method using ...of colistin resistance in poultry specimens were ...had colistin resistant mcr-1 ...carbapenem resistance gene, OXA-48, among ...
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<p>Epidemiology and molecular characterization of <em>mcr-1</em> in <em>Escherichia coli</em> recovered from patients with bloodstream infections in Changsha, central China</p>
... plasmid-mediated colistin resistance gene mcr-1 originated from China, subsequent studies from other countries reported similar ...(ESBL) resistance genes has been reported in several studies, 1,5,11 ...
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Prevalence and molecular characteristics of <em>mcr-1</em> gene in <em>Salmonella typhimurium</em> in a tertiary hospital of Zhejiang Province
... plasmid-mediated colistin resistance gene, ...to colistin and other antibiotics were assessed using broth microdilution or agar dilution ...drug resistance genes found in the mcr-1-positive ...
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Clinical Use of Colistin Induces Cross Resistance to Host Antimicrobials in Acinetobacter baumannii
... polymyxin resistance through these lipid A modifications ...the colistin-resistant isolates used in this study and found that each harbored nonsynonymous mutations in the sequences encoding one or more of ...
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