Colitis Associated Cancer
Mechanisms of Immune Signaling in Colitis-Associated Cancer
... Oxidative Stress –Induced DNA Damage in CAC For tumor initiation, distinct mutations of oncogenes or tumor-suppressor genes are required to allow subsequent tumor development. These include mutations that result in ...
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Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer
... of colitis-associated cancer ...promote colitis-associated cancer ...of colitis, such as weight loss and the severity of diarrhoea, but had no effects on histological ...
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Macrophage targeting contributes to the inhibitory effects of embelin on colitis-associated cancer
... suppresses colitis-associated ...using colitis-associated cancer (CAC) model, we demonstrated that embelin significantly depleted colon macrophages by blocking their ...
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Epidermal growth factor receptor inhibits colitis associated cancer in mice
... of colitis-associated cancer in IBD ...increasing cancer rates. Using two mouse models of colitis-associated cancer, we found that epidermal growth factor receptor ...
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Inflammation decreases keratin level in ulcerative colitis; inadequate restoration associates with increased risk of colitis associated cancer
... of cancer suggesting that keratin regulation in remission may be a pivotal factor influen- cing subsequent risk of development of colitis-associated ...
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CD98 expression modulates intestinal homeostasis, inflammation, and colitis associated cancer in mice
... and colitis-associated ...DSS-induced colitis, promoting colitis-associated tumorigenesis in ...DSS-induced colitis and colitis-associated ...and ...
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Research Article Gut Dysbiosis and Abnormal Bile Acid Metabolism in Colitis- Associated Cancer
... CAC Figure 7: Gut dysbiosis and abnormal bile acid metabolism in colitis-associated cancer. Synthesized in the liver, bile acids are transported to the intestine in the form of conjugated bile acids. ...
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Original Article PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer
... AOM on day 1 followed by 3 cycles of 2% DSS in the drinking water for 7 days and then distilled water for 14 days. Mice in control group received no drug treatment; Vehicle treated group received vehicle (4% ethanol + 5% ...
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SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development
... CAC, colitis-associated cancer; Cox-2, cyclooxygenase-2; CRC, colorectal cancer; DSS, dextran sulfate sodium; EGF, epidermal growth factor; ERK, extracellular signal regulated kinase; IBD, ...
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Inflammation decreases keratin level in ulcerative colitis; inadequate restoration associates with increased risk of colitis-associated cancer
... Taken together with the results of acute in fl ammation on keratins, we can suggest that inadequate restoration of keratin expression following acute in fl ammation may contribute to the pathogenesis of CAC by affecting ...
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The NLRP3 inf lammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
... Our data suggest that NLRP3 regulates tumorigenesis through the hematopoietic/myeloid compartment. This find ing is consistent with the known biology of NLRP3 because the vast majority of NLRP3’s function can be ...
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Up-regulation of matrix metalloproteinases in a mouse model of chemically induced colitis-associated cancer: the role of microRNAs
... colon cancer cells, attenuating the proliferation, migration, and invasion potential of murine colon cancer cells as well as angiogenesis and the growth of tumors derived from these ...inflammation ...
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S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer
... Sphingadienes are orally available sphingolipids con- taining a sphingolipid backbone harboring conjugated trans double bonds. They are found in soy products and other natural sources. 96 Sphingadienes containing double ...
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Genomic characterization of colitis associated colorectal cancer
... Conclusions: In this review, we have discussed the differences in genomic alterations between sporadic CRC and CAC. NGS in patients with IBD has the potential to detect early CAC and to suggest therapeutic targets. ...
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Protective effects of Huangqin Decoction against ulcerative colitis and associated cancer in mice
... acute colitis, we selected it for further ...prevented colitis-associated cancer. These activities were associated with decreases in markers for oxidative stress (8-oxoguanine, ...
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MyD88 adaptor like (Mal) regulates intestinal homeostasis and colitis associated colorectal cancer in mice
... Proinflammatory mediators secreted not only by hematopoietic cells that infiltrate inflamed tissue (extrinsic inflammation) but also by epithelial, stromal, and endothelial cells (intrinsic inflammation) may affect the ...
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Evolutionary history of human colitis-associated colorectal cancer
... CA-CRCs tend to have a high burden of CNAs with recurrent losses and gains distinct from S-CRCs. Here we have used multi- region genomic analysis to reveal the evolutionary history of these differences. From a clinical ...
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Orally Deliverable Nanotherapeutics for the Synergistic Treatment of Colitis-Associated Colorectal Cancer
... by cancer cells, nSN38 releases chemically unmodified drugs because of the self-hydrolyzable ester ...ameliorating colitis by oral administration of nCUR in drinking water in the initial stage of CAC is ...
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Clostridium difficile-associated colitis.
... Pathogenic strains of C diffi cile cause diarrhea and colitis via toxin production. 4 Two major toxins have been identifi ed: toxin A is a 308kD enterotoxin, and toxin B is a 269kDa cytotoxin. Both toxins are capable ...
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A Two-Locus System Controls Susceptibility to Colitis-Associated Colon Cancer in Mice
... Keywords: Colitis-associated colon cancer, genetics, azoxymethane, dextran sulfate, gene mapping Received: August 30, 2010, Accepted: Ocotober 10, 2010, Published: Ocotober 11, 2010 Copyright: © Van ...
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