Collagen-binding
Collagen binding integrin α1β1 regulates intestinal inflammation in experimental colitis
... Central to inflammatory responses are the integrin-mediated adhesive interactions of cells with their ECM-rich environment. We investigated the role of the collagen-binding integrin a 1 b 1 in intestinal ...
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1,25 Dihydroxyvitamin D3 induces collagen binding to the human monocyte line U937
... (OH)2D3). Binding was observed at 4 degrees C and was saturable; Scatchard analysis of the binding to 1,25-(OH)2D3-pretreated U937 cells indicated a single class of high-affinity binding ...induce ...
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Regulation of inflammation by collagen binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis
... Adhesive interactions play an important role in inflammation by promoting leukocyte attachment and extravasation from the vasculature into the peripheral tissues. However, the importance of adhe- sion molecules within ...
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Acceleration of wound healing in acute full-thickness skin wounds using a collagen-binding peptide with an affinity for MSCs
... the collagen with different treatments; (b) Cellular distribution in the deep ...the collagen-binding domain (CBD)/ peptide group was signifi cantly higher than that in the Scaffold group (per fi ...
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Coexpression of the collagen binding stress protein HSP47 gene and the alpha 1(I) and alpha 1(III) collagen genes in carbon tetrachloride induced rat liver fibrosis
... a collagen-binding stress protein and is assumed to act as a collagen-specific molecular chaperone during the biosynthesis and secretion of procollagen in the living ...of collagen in several ...
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Mechanical Strength and Inhibition of the Staphylococcus aureus Collagen Binding Protein Cna
... The B region has a mechanical function that is required for strong ligand binding in vivo. Another important outcome of our experiments was that Cna featured unusual mechanical prop- erties (Fig. 5). When modular ...
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Specific affinity between fibronectin and the epidermolysis bullosa acquisita antigen
... autoantibodies is in close apposition to fibronectin, a major extracellular matrix molecule that is abundant in the upper dermis of skin. In this report, we show specific affinity between fibronectin and the 290,000-D ...
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The Ciliate Protist Tetrahymena pyriformis as a Cellular Adhesion Model for the Pathogenic Bacterium Staphylococcus aureus
... fibrinogen binding protein (Clump- ing factor A or ClfA ), the fibronectin binding proteins FnBPA and FnBPB (fi- bronectin-binding protein A and B) [9] [10], the collagen binding ...
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CHARACTERIZATION OF VIRULENCE FACTORS OF STAPHYLOCOCUS SAPROPHYTICUS ISOLATED FROM WOMEN WITH CYSTITIS
... The study included isolation and identification of uropathogenic Staphylococcus saprophyticus which responsible for cystitis occurrence in young women. A total of 140 mid stream urine sample were taken from women ...
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Severe Plasmodium falciparum malaria is associated with circulating ultra large von Willebrand multimers and ADAMTS13 inhibition
... the VWF A2 domain, thereby preventing the accumulation of ULVWF multimers in normal plasma, and thus also regulating VWF functional activity [23,36]. However, it remains largely unclear how VWF proteolysis by ADAMTS13 is ...
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Functional domains on von Willebrand factor Recognition of discrete tryptic fragments by monoclonal antibodies that inhibit interaction of von Willebrand factor with platelets and with collagen
... wall collagen type III, at relatively high wall shear ...the binding of FVIII-VWF to the platelet in the presence of ristocetin but did not affect the binding of FVIII-VWF to ...the binding of ...
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Collagen induced release of interleukin 1 from human blood mononuclear cells Potentiation by fibronectin binding to the alpha 5 beta 1 integrin
... the collagen-induced IL-1 secretion. The IL-1 response to collagen from cells incubated in Fn- depleted serum was restored by the addition of either purified Fn or the 120-kD cell-binding fragment of ...
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Mussel-inspired human gelatin nanocoating for creating biologically adhesive surfaces
... cells. Binding of gelatin onto titanium was significantly enhanced by dopamine ...the binding of collagen-binding vascular endothelial growth factor and cell adhesion as compared with gelatin ...
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Type IX collagen deficiency enhances the binding of cartilage specific antibodies and arthritis severity
... Osteoarthritis (OA) and rheumatoid arthritis (RA) are both degenerative diseases of the joint and affect articular cartilage, synovium and bone with a loss of function and joint deformity. RA is, however, an inflammatory ...
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Knüppel, Larissa Dorothea (2018): FKBP10 inhibition as a promising strategy to interfere with collagen synthesis and maturation in lung fibrosis. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... I collagen and FN, both major compo- nents of the fibroblast ECM, in response to FKBP10 knockdown ...VI collagen and ...inhibit collagen VI deposition in the ECM, as no triple helical molecules can ...
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Staphylococcus aureusprotein A plays a critical role in mediating bone destruction and bone loss in
... When bone tissue gets infected it upsets the normal process of bone remodelling that is orchestrated by osteoclasts and osteo- blasts. While many attempts have been made to understand the mechanisms involved, most ...
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Binding and covalent cross linking of purified von Willebrand factor to native monomeric collagen
... from collagen by the addition of either fibronectin or ...to collagen could no longer be displaced by vWF, which suggests covalent cross-linking of vWF to collagen ...to collagen, but not to ...
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A collagen hydroxyapatite scaffold allows for binding and co delivery of recombinant bone morphogenetic proteins and bisphosphonates
... of collagen scaffolds to bind rhBMP-2 has been previously reported ...rhBMP-2 binding, as collagen remained a major ...control collagen, although follow- ing a similar sustained release ...of ...
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Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages
... impaired collagen uptake in vivo (*P = ...intratracheal collagen injection were counterstained with DAPI, and the number of retained colla- gen particles divided by the total number of nuclei in each ...
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Potential probiotic-associated traits revealed from completed high quality genome sequence of Lactobacillus fermentum 3872
... Completion of the genome sequence of L. fermentum 3872 allowed the identification of various features that may contribute to probiotic properties of this bacterium, in addition to the already described CBP-encoding gene ...
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