Collagen degradation
Glucosamine prevents in vitro collagen degradation in chondrocytes by inhibiting advanced lipoxidation reactions and protein oxidation
... cartilage degradation in ...cartilage collagen degradation in which collagen degradation induced by activated chondrocytes is mediated by lipid peroxidation ...
10
Inhibition of hyaluronan export reduces collagen degradation in interleukin 1 treated cartilage
... A possible explanation for the protective effect of hyaluronan export inhibition on collagen degradation could be that the altered composition and permeability of osteoarthritic cartilage allowed the ...
9
Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1
... proteolytic degradation of the connective tissue ...the degradation of cartilage collagen by developing immunochemical methods that permit the identification and analysis of type II collagen ...
16
Urinary collagen degradation products as early markers of progressive renal fibrosis
... and collagen degrada- tion balance eachother out and only when the disease pro- gresses, fibrogenesis become more apperent compared to degradation and fibrotic laesions start to appear ...on collagen ...
11
The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX II, is unique compared with other markers of collagen turnover
... cartilage degradation marker that has been investi- gated in response to oestrogen deprivation, and it would therefore be interesting to investigate whether oestrogen dep- rivation similarly affects other type II ...
12
Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation
... total collagen degradation, from all ...from collagen may be further metabolized before it is excreted, other markers are necessary to measure collagen ...reflects collagen metabolism ...
10
The quantitative relationship of urinary peptide hydroxyproline excretion to collagen degradation
... to collagen breakdown, known quantities of radioactive hydroxyproline peptides were administered to unlabeled animals and excertion of radioactivity in respiratory carbon dioxide, urine, and feces was ...of ...
11
Collagen Degradation and the Response to Parathyroid Extract in the Intact Rhesus Monkey
... the degradation of collagen was followed by the excretion of hydroxyproline- 14 ...of collagen with half-lives of 1 to 2, 2 to 3, and 50 to 70 ...
9
Type XVIII collagen degradation products in acute lung injury
... from collagen XVIII which is a major pro- teoglycan of both endothelial and epithelial basement mem- brane ...XVIII collagen in their basement membranes. Three forms of collagen XVIII precursor, ...
9
Dose dependent regulation of cell proliferation and collagen degradation by estradiol on ligamentum flavum
... the degradation of extracellular matrix components via the PI3K ...to collagen then contributes to the development of degenerative hypertrophic change of the ligamentum ...elastin degradation, ...
10
Isotopic Studies on Collagen Degradation and the Urine Excretion of Hydroxyproline
... Comparable values for the specific activity of hydroxyproline from insoluble collagen and urine were found in two rats examined after 6 days, and in rat V the observed specific activitie[r] ...
9
Selective inhibition of human diploid fibroblast collagen synthesis by interferons
... of collagen synthesis by these cells independently of their effect on cell ...that collagen synthesis inhibition was a constitutive property of ...IFNs. Collagen synthesis inhibition by IFNs was ...
6
Degradation of collagen by a human granulocyte collagenolytic system
... This report suggests a mechanism for collagen degradation mediated by human granulocytic leukocytes. A specific collagenase, which is extractable from human granulocytes, has been partially purified by DEAE ...
9
Fundamental Insights into Arterial Remodelling; Strain Mediated Degradation of Arterial Collagen
... in degradation rate with increasing strain for circumferential and axial specimen (Figure ...V-shaped degradation response observed in reconstituted collagen tapes (Huang and Yannas, 1977) as well as ...
214
Antifibrotic Effects of Limbal Mesenchymal Stem Cells-Conditioned Media (LMSCs-CM) on Human Tenon’s Fibroblasts (HTFs) in Glaucomatous Eyes: Comparison with Mitomycin C
... inhibit collagen synthesis in line with induction of collagen degradation in ...and collagen I synthesis ...of collagen, the main component of the ECM, were found after MSC ...
9
Effect of Phase I Therapy on Salivary Carboxyterminal Telopetide of Type I Collagen in Chronic Periodontitis Patients
... I collagen degradation products in serum (S-ELISA) with an isomerised form of an eight amino acid ...I collagen. He reported that Asp-Gly site present in type I collagen is prone for ...
102
Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD
... high degradation and forma- tion of type VI collagen may in part be a biochemical reflection of important clinical features of COPD, in- cluding poor ability to walk, as assessed by the 6-min walk test ...
11
Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo
... gelatin-film degradation, whereas control Fc-scFv DES showed no effect (Figure 3A, right panel, GM6001 acts in a similar manner to CT1746 and the two were used ...inhibited collagen degradation by ...
20
Effect of budesonide on fibroblast-mediated collagen gel contraction and degradation
... on degradation of collagen, has not been fully ...on collagen degradation as well as on MMP-1, MMP-3, and MMP-9 release, activation, and mRNA expression in human lung ...along collagen ...
9
Imbalance in extracellular matrix degradation in urethral stricture
... total collagen percentage was ...in collagen levels and thus ...of collagen deposition but also by a decreased level of collagen ...total collagen, and nor was there any correlation ...
6