Collagen induced arthritis
Therapeutic effect of quercetin in collagen-induced arthritis
... Rheumatoid Arthritis (RA). Collagen- induced arthritis (CIA) is the most common animal model to study the pathogenesis of ...in collagen-induced arthritis in C57BL/6 ...
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Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen induced arthritis model
... of collagen-induced arthritis (CIA) has many similarities to RA ...II collagen (CII) – the collagen found in joint cartilage – induces T cell activation, anti-CII autoantibody ...
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Human embryonic stem cell derived mesenchymal stromal cells ameliorate collagen induced arthritis by inducing host derived indoleamine 2,3 dioxygenase
... rheumatoid arthritis (RA) ...of collagen induced- arthritis (CIA), a well-characterized model of chronic arthritis [14, ...of arthritis in CIA ...of arthritis in mice by ...
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Perforin deficiency attenuates collagen induced arthritis
... Collagen-induced arthritis (CIA) is an experimental model of arthritis inducible in susceptible strains of mice, for example DBA1/J, by immunization with bovine collagen type II (CII) ...
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Inducible costimulator is essential for collagen induced arthritis
... rheumatoid arthritis using a collagen-induced arthri- tis ...to collagen-induced arthritis and exhibited absence of joint tissue ...with collagen, exhibited reduced ...
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Mast cell depletion in the preclinical phase of collagen induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile
... of arthritis induction ...in arthritis models based on the infusion of autoreactive antibodies such as with the K/BxN ...the collagen-induced arthritis (CIA) model where T cells ...
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Collagen induced arthritis and imiquimod induced psoriasis develop independently of interleukin 33
... rheumatoid arthritis (RA) and its models; we recently demonstrated that exogenous IL-33 could inhibit collagen-induced arthritis (CIA) in C57BL/6 ...to arthritis, and the disease is not ...
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Amelioration of collagen induced arthritis by thrombin inhibition
... of collagen-induced arthritis (CIA) in the ...was induced in male DBA/1J mice using native chicken type II ...of arthritis (curative ...once arthritis was established, ...
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Interleukin 7 aggravated joint inflammation and tissue destruction in collagen induced arthritis is associated with T cell and B cell activation
... CIA: collagen-induced arthritis; CII: chicken collagen type II; DN: double negative; DP: double positive; EGF: epidermal growth factor; FGF: fibroblast growth factor; HE: hematoxylin-eosin; ...
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Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice
... on collagen prepared from tissue com- plexed with not very well defined matrix molecules, and instead use synthetic and recombinant triple-helical CII peptides containing identified epitopes known to be ex- posed ...
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Prokineticin 2 antagonist, PKRA7 suppresses arthritis in mice with collagen induced arthritis
... with collagen-induced arthritis (CIA), an animal model of rheumatoid ...of arthritis was compared between treated ( n = 12) and untreated ( n = 12) ...
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Gait analysis in a murine model of collagen induced arthritis
... Rheumatoid arthritis (RA) is an autoimmune disease charac- terized by chronic inflammation in the limbs and joints, cyclic progressive cartilage and bone destruction, and severe disa- bility ...[2,3]. ...
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Interleukin 21 signaling in B cells, but not in T cells, is indispensable for the development of collagen induced arthritis in mice
... Collagen-induced arthritis (CIA) is a widely used animal model of RA, and CIA can be induced by immunization of mice (or rats) with type II collagen ...
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Humoral and Cellular Sensitivity to Collagen in Type II Collagen Induced Arthritis in Rats
... latter collagen induced brisk cellular and humoral responses that were equivalent whether complete Freund's adjuvant or incomplete Freund's adjuvant were ...be induced by native type II collagens ...
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Nature and specificity of the immune response to collagen in type II collagen induced arthritis in mice
... incorporation by mononuclear cells cultured in the presence of collagen. The maximal proliferative response to collagen occurred at 2 wk after immunization. Equally good incorporation of label occurred when ...
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Collagen epitope expression on B cells is sufficient to confer tolerance to collagen induced arthritis
... Development of CIA is dependent on both T cells [36] and B cells [37]. Further, germline-encoded IgM and IgG CII-specific B cells are not eliminated by central toler- ance mechanisms [38, 39]. During CIA T-cell help is ...
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CD97 neutralisation increases resistance to collagen induced arthritis in mice
... Still, we did observe a significant reduction in arthritis activity even when treatment was initiated in chronic arthritis. The natural course of CIA could also explain the relatively small dif- ferences in ...
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Bystander suppression of collagen induced arthritis in mice fed ovalbumin
... Clinical manifestations of arthritis in mice fed ovalbumin (OVA). Mice were fed OVA or a standard diet for 7 days. One week after the last day on the OVA diet, the mice were immunized with BCII or BCII mixed with ...
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Collagen induced arthritis in common marmosets: a new nonhuman primate model for chronic arthritis
... The common marmoset may fill a niche as an attractive alternative nonhuman primate species for preclinical evaluation of new biologicals in the field of arthritis. The small size of the common marmoset compared ...
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A proinflammatory role for Fas in joints of mice with collagen induced arthritis
... to collagen in lpr/lpr ...to collagen II is significantly stronger than that of normal T ...the collagen-II- specific T-cell precursor frequency was observed, this could reflect an increase in the ...
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