collapsin response mediator protein
Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias
... Collapsin response mediator protein-2 (CRMP2) is the first identified member of the collapsin response medi- ator protein (CRMP) family ...by protein phosphatase 2A ...
12
Silencing collapsin response mediator protein-2 reprograms macrophage phenotype and improves infarct healing in experimental myocardial infarction model
... library. Collapsin response mediator protein-2 (CRMP2), a multifunctional adaptor protein first described in the CNS and thoroughly studied in neurons [9-11], was identified as a novel ...
12
Regulation of centrosome movements by Numb and the Collapsin Response Mediator Protein during Drosophila sensory progenitor asymmetric division
... Asymmetric cell division generates cell fate diversity during development and adult life. Recent findings have demonstrated that during stem cell divisions, the movement of centrosomes is asymmetric in prophase and that ...
12
Identification and structural analysis of C-terminally truncated collapsin response mediator protein-2 in a murine model of prion diseases
... of collapsin response mediator protein-2 (CRMP-2; 61 kDa) decreased in the late stages of the disease, while the amount of its truncated form (56 kDa) increased to comparable levels observed ...
12
Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders
... sin-response mediator protein-2 ...this protein in growth cone collapse and neuronal develop- ment makes it an intriguing candidate for regulating neurogenesis in neurodegenerative ...this ...
23
A case of paraneoplastic optic neuropathy and outer retinitis positive for autoantibodies against collapsin response mediator protein-5, recoverin, and α-enolase
... Patients with CAR basically exhibit no abnormal retinal appearances in the initial stage and may later develop diffuse pigment epithelial degeneration similar to retin- itis pigmentosa together with photoreceptor ...
6
Collapsin response mediator protein 4 promotor methylation level as a potential predictor for diagnosing primary malignant lymphoma of the prostate
... ing response mediator proteins (CRMPs) (CRMP1-5) are associated with several malignant tumors, including lung, breast, colorectal and prostate cancer ...
10
Detection of autoantibodies against heat shock proteins and collapsin response mediator proteins in autoimmune retinopathy
... shock protein 60 (hsp60) and collapsin response mediator protein 2 (CRMP2) as possible autoantigens frequently observed in patients with CAR, MAR and ...
9
TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation
... the collapsin response mediator protein 2 (CRMP2) SUMO-incompetent mutant protein (CRMP2-K374A), which causes a significant reduction in Na V ...
14
Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2
... CRMP-2, collapsin response mediator protein 2; DRG, dorsal root ganglia; GSK3 β , glycogen synthase kinase 3 β ; SCI, spinal cord injury; SEM, standard error of the ...
19
Molecular Characterization of the Dbf4/Drf1 Dependent Kinase (DDK) and the DNA Replication Checkpoint Mediator Claspin in Xenopus Egg Extracts
... 2AG mutant version of Claspin fragment that is incapable of binding to Chk1 (owing to mutations in serines 864 and 895) was still able to interact with Drf1, suggesting that the role of DDK interaction with Claspin is ...
194
The role of the immune response mediator genes polymorphism in the predisposition to juvenile idiopathic arthritis
... immune response mediator genes polymorphic loci with the risk of the development of JIA and its clinical variants – Rheumatoid factor positive polyarthritis, Rheumatoid factor negative polyarthritis (only ...
9
P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth
... P300 protein positively correlates with FASN protein levels in a cohort of human PCa ...key mediator of P300-induced growth of PCa cells in culture and in ...
15
Neutrophil protein kinase Cδ as a mediator of stroke reperfusion injury
... Thrombolysis is widely used to intervene in acute ischemic stroke, but reestablishment of circulation may paradoxically initiate a reperfusion injury. Here we describe studies with mice lacking protein kinase Cd ...
9
The immune response mediator genes polymorphic variants as predictors of the etanercept efficacy in juvenile idiopathic arthritis
... 70) response was regarded as the presence of the response to etanercept (otherwise – as the absence), while achieving clinical remission on medication – as the sufficient response (otherwise – as the ...
5
Aggregating platelets contract isolated canine pulmonary arteries by releasing 5 hydroxytryptamine
... contractile response to ...predominant mediator of the contractile response triggered by platelet aggregation; and (b) unlike in other blood vessels, the endothelium cannot curtail the contractile ...
7
N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling
... domains, which combined mutually to form mature Notch dimers. Then the activation of Notch signaling by its ligands would lead to sequential cleavages by tumor necrosis factor-a-converting enzyme (S2) and r-secretase ...
15
Negative regulation by thyroid hormone receptor requires an intact coactivator binding surface
... In vitro characterization of TR-β (E457A). (A) Schematic representation of the TR-β isoforms and the location of the E457A mutation. Amino acid numbers are given for the human mutation in the mouse TR- β locus. DBD, ...
8
Fabrication of Eu3+ Polymeric Membrane Ion Selective Sensor
... The average time required for the Eu 3+ sensor to reach a potential within ± 1 mV of the final equilibrium value after successive immersion in a series of Eu 3+ solutions, each having a 10-fold difference in ...
5
Sympathetic modulation of biochemical and physiological response to immune degranulation in canine bronchial airways in vivo
... Sympathetic stimulation during Ascaris suum antigen challenge caused complete inhibition of bronchial smooth muscle contractile response to i.a. antigen (P less than 0.001), and a significant AVd in histamine ...
10