collapsin response mediator protein 2
Identification and structural analysis of C-terminally truncated collapsin response mediator protein-2 in a murine model of prion diseases
... of collapsin response mediator protein-2 (CRMP-2; 61 kDa) decreased in the late stages of the disease, while the amount of its truncated form (56 kDa) increased to comparable ...
12
Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias
... Collapsin response mediator protein-2 (CRMP2) regulates axonal growth cone extension, and increased CRMP2 phosphorylation may lead to axonal ...to protein phosphatase ...
12
Silencing collapsin response mediator protein-2 reprograms macrophage phenotype and improves infarct healing in experimental myocardial infarction model
... library. Collapsin response mediator protein-2 (CRMP2), a multifunctional adaptor protein first described in the CNS and thoroughly studied in neurons [9-11], was identified as a ...
12
Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders
... sin-response mediator protein-2 ...this protein in growth cone collapse and neuronal develop- ment makes it an intriguing candidate for regulating neurogenesis in neurodegenerative ...
23
Detection of autoantibodies against heat shock proteins and collapsin response mediator proteins in autoimmune retinopathy
... shock protein 60 (hsp60) and collapsin response mediator protein 2 (CRMP2) as possible autoantigens frequently observed in patients with CAR, MAR and ...
9
TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation
... the collapsin response mediator protein 2 (CRMP2) SUMO-incompetent mutant protein (CRMP2-K374A), which causes a significant reduction in Na V ...
14
Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2
... CRMP-2, collapsin response mediator protein 2; DRG, dorsal root ganglia; GSK3 β , glycogen synthase kinase 3 β ; SCI, spinal cord injury; SEM, standard error of the ...
19
Collapsin response mediator protein 4 promotor methylation level as a potential predictor for diagnosing primary malignant lymphoma of the prostate
... Ten cases of PMLP patients with age of onset from 57 to 82 years old and a median age of 69 years old were treated in the Third Affiliated Hospital and the First Hos- pital of Sun Yat-sen University during November 2006 ...
10
Regulation of centrosome movements by Numb and the Collapsin Response Mediator Protein during Drosophila sensory progenitor asymmetric division
... 2). This shows that Numb is necessary to promote an early posterior apical centrosome movement. Furthermore, the overexpression of Numb induces a premature movement of both the anterior and the posterior ...
12
A case of paraneoplastic optic neuropathy and outer retinitis positive for autoantibodies against collapsin response mediator protein-5, recoverin, and α-enolase
... Recombinant human CRMP-5, α-enolase, and carbonic anhydrase II proteins were purchased from Abnova (Taipei, Taiwan), Biovision (Milpitas, CA), and ATGen (Gyeonggi-do, South Korea), respectively. Proteins were solubilized ...
6
Bcl 2–related protein A1 is an endogenous and cytokine stimulated mediator of cytoprotection in hyperoxic acute lung injury
... twice with ice-cold PBS containing 1 mM sodium orthovanadate and 1 mM sodium fluoride, and lysed with lysis buffer (15 mM HEPES [pH 7.9], 10% glycerol, 0.5% NP-40, 250 mM NaCl, 0.1 mM EDTA, 1 mM sodium orthovanadate, 10 ...
11
Aggregating platelets contract isolated canine pulmonary arteries by releasing 5 hydroxytryptamine
... contractile response to ...predominant mediator of the contractile response triggered by platelet aggregation; and (b) unlike in other blood vessels, the endothelium cannot curtail the contractile ...
7
Aberrant islet unfolded protein response in type 2 diabetes
... unfolded protein response ...type 2 diabetes remains to be ...binding protein 1 (sXBP1), and phosphorylation of eukaryotic initiation factor 2 (eIF2a), to evaluate the three distinct ...
7
The role of the immune response mediator genes polymorphism in the predisposition to juvenile idiopathic arthritis
... et al. (2009), Thompson S.D. et al. (2010) [12-18]. According to Crawley E. et al. (1999), the presence of ATA-containing genotypes of the IL10 gene rs1800896, rs1800871 and rs1800872 polymorphic loci haplotypes was ...
9
Molecular Characterization of the Dbf4/Drf1 Dependent Kinase (DDK) and the DNA Replication Checkpoint Mediator Claspin in Xenopus Egg Extracts
... 2.2.9 Cell Culture and Immunofluorescence—XTC-2 cells were grown on poly-D- lysine-coated coverslips in 61% Leibovitz's (L-15) medium supplemented with 10% fetal calf serum and antibiotics. Caffeine-treated cells ...
194
The immune response mediator genes polymorphic variants as predictors of the etanercept efficacy in juvenile idiopathic arthritis
... 70) response was regarded as the presence of the response to etanercept (otherwise – as the absence), while achieving clinical remission on medication – as the sufficient response (otherwise – as the ...
5
Negative regulation by thyroid hormone receptor requires an intact coactivator binding surface
... Thyroid hormone (TH) action is mediated by TH receptors (TRs), which are members of the nuclear hormone receptor superfamily. In vitro studies have demonstrated that TR activity is regulated by interactions with core- ...
8
Neutrophil protein kinase Cδ as a mediator of stroke reperfusion injury
... the response of these animals to stroke, we first used a model of permanent cerebral ischemia in which an infarction in the MCA distribution is produced by occluding the ves- sel lumen with a ...(Figure 2, ...
9
Metabolic response of people with type 2 diabetes to a high protein diet
... 30% protein diet, the decrease was ...high protein diet may impair renal function, the creatinine clearance was deter- mined at the end of the period of time the subjects ingested the 15% protein ...
7
Analysis of the Humoral Immune Response toChlamydia Outer Membrane Protein 2
... Serology has provided important information regarding the wide range of diseases associated with C. trachomatis, espe- cially infant pneumonia, lymphogranuloma venereum, and chronic genital infections. MOMP, Omp2, GroEL, ...
6