colon-carcinoma cells
ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF SELECTED PLANT EXTRACTS AGAINST HUMAN NON SMALL CELL LUNG ADENOCARCINOMA (A549), HUMAN COLON CARCINOMA CELLS (HCT116) AND CHINESE HAMSTER NORMAL OVARY CELLS (AA8)
... Research studies are currently geared in the evaluation and determination of the cytotoxicity and antioxidant activity of plant extracts. These are important in obtaining possible plant-based anti- oxidant-supplements ...
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Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo
... Platelet-adhesive protein-tumor cell interaction was studied in vitro and in vivo. Monoclonal antibody 10E5, which inhibits binding of fibronectin and von Willebrand factor to the platelet membrane glycoprotein ...
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Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo
... of colon carcinoma cells was markedly attenuated upon obliteration of perlecan gene expression and these effects correlated with reduced responsiveness to and affinity for mitogenic keratinocyte ...
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Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells
... tumor cells. PC function in the human and murine colon carcinoma cell lines HT-29 and CT-26, respectively, was inhibited using siRNA targeting the PCs furin, PACE4, PC5, and PC7 or by overexpres- ...
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Comparing the cytotoxicity of taurolidine, mitomycin C, and oxaliplatin on the proliferation of in vitro colon carcinoma cells following pressurized intra peritoneal aerosol chemotherapy (PIPAC)
... Intraperitoneal chemotherapy (IPC) has gained increasing acceptance in the past 20 years and has since been fre- quently used and extensively studied. Limitations concern- ing drug delivery to solid cancer formations ...
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Regulation of herpes simplex virus γ134 5 expression and oncolysis of diffuse liver metastases by Myb34 5
... Myb34.5 is a herpes simplex virus 1 (HSV-1) mutant deleted in the gene for ribonucleotide reductase (ICP6). It also carries a version of g 1 34.5 (a viral gene product that promotes the dephosphorylation of eIF-2a) that ...
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Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor
... human colon carcinoma cells induced to express polymeric immunoglobulin receptor, but not those lacking the ...epithelial cells grown on collagen gels, which induce the expression of polymeric ...
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Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus.
... We have identified the major cellular endoprotease that activates the fusion (F) glycoprotein of measles virus (MV) and have engineered a serine protease inhibitor (serpin) to target the endoprotease and inhibit the ...
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FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells
... renal carcinoma (Caki, ACHN, and A498), human breast carcinoma cells (MDA-MB-231), and human colon carcinoma cells (HT29) were obtained from the American Type Culture Collection ...
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Evidence that Replication of the Antitumor Adenovirus ONYX-015 Is Not Controlled by the p53 and p14ARF Tumor Suppressor Genes
... 293 cells (ATCC CRL-1573) were used for propagating wt Ad5 and ONYX-015, as they contain the E1a and E1b ...cancer cells (ATCC CCL-185), HepG2 hepatoma cells (ATCC HB-8065), RKO colon ...
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Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
... Angiogenesis represents a coordinated multicellular process involving a wide variety of molecules, including growth factors, ECM components, adhesion receptors, and matrix-degrading enzymes. HSPGs and HSPG- degrading ...
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Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX
... human colon carcinoma cells, we demonstrate the induction of BAX-dependent apoptosis at pharmacologically relevant concentrations of the HSP90 inhibitor 17-AAG both in vitro and in tumor xenografts ...
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Generation of Herpesvirus Entry Mediator (HVEM)-Restricted Herpes Simplex Virus Type 1 Mutant Viruses: Resistance of HVEM-Expressing Cells and Identification of Mutations That Rescue Nectin-1 Recognition
... B cells (14) and two HSV-seronegative in- dividuals ...HT29 cells to K26-gD:A3C/Y38C is not due to an intrinsic defect in HT29 HVEM or to an inability of this receptor to interact with ...of cells ...
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In vivo migration of labeled autologous natural killer cells to liver metastases in patients with colon carcinoma
... cytes, cells were extensively washed in medium, counted and suspended in the adherence medium supplemented with 1 mM CaCl 2 , 1 mM MgCl 2 , 100 U/ml heparin and 6,000 IU/ml of rIL-2 (Chiron ...non-adherent ...
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In vitro and in vivo anti colon cancer effects of Garcinia mangostana xanthones extract
... recorded before starting the treatment and at 5-days intervals for 20 days. Animals were treated by mixing the extract with the animal food at 0.25% and 0.5% extract: food ratio (wt/wt). Tumor dimensions were measured by ...
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Plaque assay for human coronavirus NL63 using human colon carcinoma cells
... LLC-MK2 cells takes more than 7 days until first signs of weak CPE become ...CaCo-2 cells, five plaque assays on virus dilution series were done with Avicel overlays and terminated by fixation after 1, 2, ...
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Cell culture study on the cytotoxic effects of “Cureit” a novel bio available curcumin anti cancer
... Cancer is a hyper proliferative disorder that metastasize into the vital organs in the body through invasion followed by angiogenesis and distant metastasis. Curcumin suppresses the proliferation of a wide variety of ...
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Original Article Bcl-2/Bax switch was flipped during apoptosis of HCT116 colon cancer cells induced by a traditional Chinese medicine, BanxiaXiexin Decoction
... HCT116 cells, we realized there were some problems that remained ...tumor cells, multiple signaling path- ways such as NF-κB signaling [14], Notch sig- naling [15], and Wnt signaling [16] are involved in ...
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Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice
... negative tumors the incidence of metastasis was only 10% (2 out of 19), whereas Sema3E-positive primary tumors had a 58% inci- dence of metastasis (14 out of 24). Although the size of this sample is small, Fisher’s exact ...
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The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells.
... The IGF axis consists of two ligands; IGF-I and IGF-II, their receptors IGF-IR, the IGF-II/mannose 6-phosphate receptor (IGF-II/M6-PR) and IGF-IR-insulin receptor hybrids, and six high affinity IGF binding proteins ...
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