Colony Stimulating Factor Receptor
Increased granulocyte colony stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony stimulating factor receptor mutation derived from a patient with severe congenital neutropenia
... granulocyte colony-stimulating factor receptor (G-CSFR) in the pathogenesis of severe con- genital neutropenia (SCN) and the subsequent development of acute myeloid leukemia (AML) is ...
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Tumor necrosis factor downregulates granulocyte colony stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes
... G-CSF receptor numbers on purified blood granulocytes are also downmodulated by ...G-CSF receptor expression becomes evident within 10 min after incubation of the cells with TNF at 37 degrees C and is not ...
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A study of the granulocyte-macrophage colony stimulating factor receptor (GM-CSFR) in leukaemia
... inhibit receptor phosphorylation [Stomski et al, ...both receptor chains in order to trigger a and Pc association [Stomski et al, ...this receptor alone but bound with high affinity when this mutant ...
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The expression and regulation of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR)
... certain receptor systems, not all the internalised receptors are degraded, some are recycled to the cells surface (Knutson ...many receptor systems (Dean et al ...
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Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco
... Granulocyte colony-stimulating factors (G-CSF) are recommended for both treating and preventing chemotherapy-induced ...proangiogenic factor is vascular endothelial growth factor ...
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Expression and function of the granulocyte-macrophage colony-stimulating factor receptor durning myeloid differentiation
... kinase receptor sevenless and the Drosophila epidermal growth factor (EGF) receptor (Rubin et ...to receptor-m ediated Ras activation (Yang et al., 1995). G row th factor stim ulation ...
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A functional granulocyte colony stimulating factor receptor is required for normal chemoattractant induced neutrophil activation
... G-CSF receptor is pro- viding unique signals required for normal PMN ...chimeric receptor containing the extracellular and transmembrane domains of the G-CSFR fused to the cytoplasmic domain of the ...
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Isoforms of the granulocyte-macrophage colony-stimulating factor receptor
... the receptor binds GM-CSF with the expected low affinity but with approximately 10% of the binding sites compared to the main GM-CSFRa ...affinity receptor when co-expressed with pc rather than the expected ...
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Isolation of new oncogenic forms of the murine c-fms gene.
... the receptor for the macrophage colony-stimulating factor, which plays a key role in the proliferation and differentiation of cells of the myelomonocytic ...macrophage ...
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MicroRNAs and Their Role in Bone Remodeling and Pathogenesis
... - Receptor activator of nuclear factor kappa-B ligand; M-CSF - macrophage colony- stimulating factor; TRAP - Tartrate-resistant acid phosphatise; CTR - Calcitonin receptor; ...
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Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin
... this, receptor tyrosine kinases (RTK), among the most frequently modulated molecular hubs within chemoresistant tumors [31], may appear as ideal candidates to transduce stress-induced micro-environmental changes ...
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<p>Resistance Mechanism of PD-1/PD-L1 Blockade in the Cancer-Immunity Cycle</p>
... hydrocarbon receptor; APCs, Antigen-presenting cells; B2M, β 2 microglobulin; CSF-1R, Colony-stimulating growth factor receptor; CTLs, Cytotoxic T lymphocytes; CTLA-4, Cytotoxic ...
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Induction of tumour necrosis factor receptor expressing macrophages by interleukin 10 and macrophage colony stimulating factor in rheumatoid arthritis
... TNF receptor superfamily, chemokine receptors, growth factor receptors, TLRs, and TNF receptor-associated factors (TRAFs), although it also induced the endogenous JAK (Janus kinase) kinase inhibitor ...
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Mechanisms of amphibian macrophage development: characterization of the Xenopus laevis colony stimulating factor 1 receptor
... recognition receptor expression between tadpoles and adults, and a physiological necessity for more prominent adult monopoietic responses to in- flammatory, rather than viral ...the receptor (Chen et ...
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Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α
... macrophage-colony-stimulating factor; ranKl, receptor activation of nuclear factor κB ligand; TraP, tartrate-resistance acid phosphatase; BMMs, bone marrow–derived monocyte/macrophage ...
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A screen for peptide agonists of the G CSF receptor
... Granulocyte-colony stimulating factor (G-CSF) is one the most widely employed protein ...ligand: receptor stoichiome- try to its cytokine like receptor (G-CSF-R) which recruits in turn ...
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Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade
... colony-stimulating factor 1 receptor (CSF1R) decreased TAMs and reprogrammed TAMs to promote antigen presentation and antitumor T cell activity, increased CD3+CD8+ cytotoxic T-lymphocytes ...
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Bone marrow drives central nervous system regeneration after radiation injury
... granulocyte-colony stimulating factor (G-CSF) receptor knockout mouse model in combination with bone marrow cell transplantation, MRI, and neurocognitive functional assessments, we demonstrate ...
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Osteoclasts; culprits in inflammatory osteolysis
... one receptor, the tyrosine kinase ...its receptor in osteoclastogenesis is established by the fact that op/op mice, with a loss of function mutation in the Csf1 gene [38], and those deleted of c-Fms [66], ...
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Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date
... granulocyte-macrophage colony-stimulating factor (GM-CSF), known to be a hematopoietic factor, is also one of the proinflammatory cytokines involved in macrophage activation, crucial for the ...
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