Colorectal adenoma
Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma
... the colorectal adenoma-to-carcinoma sequence represents a classical cancer progression model, the evolution of the mutational landscape underlying this model is not fully ...of colorectal high-grade ...
11
Many private mutations originate from the first few divisions of a human colorectal adenoma.
... Intratumoral mutational heterogeneity (ITH) or the presence of different private mutations in different parts of the same tumor is commonly observed in human tumors. The mechanisms generating such ITH are uncertain. Here ...
16
Association of a New Germline Variant in the MUTYH DNA Glycosylase Gene with Colorectal Adenoma Transformation into Malignancy
... with colorectal adenoma were homozygous for the missense mutation E480X [23] ...to colorectal carcinogenesis due to immunosuppression and altered immune response [27] ...
11
Meat-derived carcinogens, genetic susceptibility and colorectal adenoma risk
... on colorectal adenoma ...and colorectal adenoma risk among CYP1B1 and XPD genotypes that conferred lower bioactivation and higher DNA repair activity were ...3 Colorectal adenoma ...
12
Over-expression of AURKA SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression
... Although colorectal adenoma (CRA) is the precursor of CRC, the majority of CRAs do not progress into CRCs; only 5% of adenomas are estimated to develop into carcinomas [7, ...
16
Colorectal adenoma and carcinoma specific miRNA profiles in biopsy and their expression in plasma specimens
... in colorectal cancer (CRC), but less is known about miRNA expression profiles in colorectal ...the colorectal adenoma dysplasia ...on colorectal biopsies and plasma samples (20 normals; ...
14
Original Article Correlation between narrow-band imaging endoscopy results and hPTTG expression indicated by angiogenensis and its distribution in the initial phase of colorectal adenoma-carcinoma sequence
... of colorectal carcinoma and adeno- ma, and to evaluate the feasibility and validity of NBI in vivo visualizing ...with colorectal pol- yps, which were pathologically confirmed as early carcinoma, ...
7
Metabolic factors accelerate colorectal adenoma recurrence
... The main pathophysiological abnormality associated with increased levels of metabolic factors is visceral fat deposition. Visceral fat deposition is known to be associ- ated with insulin resistance, hyperinsulinemia and ...
9
Original Article Metformin may lower the risk of colorectal adenoma in diabetic patients: a meta-analysis
... Abstract: Previous studies have reported discordant results regarding the relationship between metformin use and the development of colorectal adenoma. Therefore, a meta-analysis of retrospective studies ...
9
Betacatenin Expression in Colorectal Adenoma and Carcinoma
... IN COLORECTAL ADENOMA AND CARCINOMA” under my guidance and supervision at Government Kilpauk Medical College, Chennai, in partial fulfilment of the regulations laid down by the Tamilnadu ...
123
Arachidonic acid and colorectal adenoma risk: a Mendelian randomization study
... and colorectal adenomas, we conducted a Mendelian randomization (MR) analysis using rs174537 as an instrumental variable ...Tennessee Colorectal Polyps ...any colorectal adenoma on colonoscopy ...
6
Original Article Meta-analysis of the association between cruciferous vegetables intake and colorectal adenoma risk
... Abstract: Aim: Quantification of the association between intake of cruciferous vegetables (CV) and the risk of colorectal adenoma (CRA), and established precursors for colorectal cancer (CRC) remain ...
11
A randomized controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme (The seAFOod Polyp Prevention Trial): study protocol for a randomized controlled trial
... an adenoma, regular use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs, regular use of fish oil supplements and concomitant warfarin or anti-platelet agent ...of colorectal adenomas and the ...
11
Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.
... To our knowledge, no previous studies have examined associations between genetic variants in PGES, EP2, EP4, and PGDH and risk of adenoma. However, although our findings require confirmation in additional studies, ...
28
Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.
... b Number of principal components that explain ≥80% of the variance in polyp risk c Likelihood ratio test comparing a model with principle components + age and sex to a model containi[r] ...
11
Risk of eighteen genome-wide association study-identified genetic variants for colorectal cancer and colorectal adenoma in Han Chinese
... a colorectal cancer screening programme conducted in the same regions and underwent a colonoscopy during the same time ...genetic colorectal cancer syndromes ...
13
Estimation of colorectal adenoma recurrence with dependent censoring
... baseline adenoma and multiplicity (number of baseline adenomas) are significantly associ- ated with risk of recurrence and previous polyp history is marginally associated with risk of ...
9
Obesity, diabetes and the risk of colorectal adenoma and cancer
... Obesity could be evaluated through several different solid anthropometric indexes such as BMI, waist circum- ference (WC) and waist-to-hip ratio (WHR). In a recent study, Wambui et al. showed that WC as compared to BMI ...
10
Back-to-Back Comparison of Auto-Fluorescence Imaging (AFI) Versus High Resolution White Light Colonoscopy for Adenoma Detection
... of colorectal adenoma, particularly flat and depressed adenomas, but not for elevated ...elevated adenoma is easily detected as a reddish and protruding lesion by HRE because HRE can detects ab- ...
8
Elevated serum triglyceride and low-density lipoprotein cholesterol promotes the formation of colorectal polyps
... of colorectal adenoma increases with age ac- cording to the European and Asia-Pacific guidelines [28, 29], and this was supported by the positive correlation between higher age and the formation of polyps ...
6