Comparison of persistent and transient sodium channels
Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels
... Examination of the structures of PIIIA reveals that the po- sitions of some side chains are less precisely defined than others. Although there has been no quantitative investigation of the correlation between surface ...
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Solution structure of μ-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels
... Examination of the structures of PIIIA reveals that the positions of some sidechains are less precisely defined than others. Although there has been no quantitative investigation of the correlation between surface ...
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Heterogeneity, transient and persistent technical efficiency of Polish crop farms
... The above-presented differences in TE scores between the considered models show that using an appropriate model is essential, since it leads to different policy recommendations. In our empirical analysis, the models ...
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Breakdown of accommodation in nerve: a possible role for persistent sodium current
... the transient sodium channel ...most transient sodium channels will go through an open state before entering an inactivated state ...of transient sodium channel function ...
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The Transient and Persistent Efficiency of Italian and German Universities: A Stochastic Frontier Analysis
... cross-country comparison displays if the overall efficiency difference between countries is related to individual performance of their universities or their HE ...by persistent, structural ...
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Sodium channels in cardiac myocytes
... TTX-sensitive persistent current following a much larger, transient current was recorded in single cardiac myocytes isolated from rat ventricular, atrial or toad sinus venosus tissues using the tight seal, ...
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Inherited disorders of voltage gated sodium channels
... Muscle sodium channelopathies Disturbances in the function of muscle Na V Chs can affect the ability of skeletal muscle to contract or ...a transient state of hypo- excitability or inexcitability in which ...
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Painful and painless mutations ofSCN9AandSCN11Avoltage-gated sodium channels
... transducing channels, like the transient receptor potential (TRP) channels, is often involved in many forms of pathological pain ...TRP channels in nerve ...
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Sodium and potassium ion channels as targets for the control of epilepsy
... induced persistent current in rat neocortical cells (Astman et a l, ...and persistent component o f the N ...peak transient nor the persistent current amplitudes on application o f ...the ...
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The role of Transient Receptor Potential (TRP) channels in the pathogenesis of COPD
... direct comparison to be made between the genetically deficient mice and the C57BL/6 wild-type colony in in vivo models, with a high degree of certainty that any phenotypic differences are caused only by the ...
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Abstract: ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor
... internalization. Persistent exposure to TRPV1 receptor agonists, such as the vanilloid capsaicin, makes cells partially or totally insensible to subsequent stimuli, a process known as ...the channels ...
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Fibrinolytic Regulation of Pulmonary Epithelial Sodium Channels: a Critical Review
... The third set of experiments was to explore the underlying pharmacological mechanisms for uPA to up regulate ENaC. The hypothesis is that uPA may activate ENaC through proteolysis. My results show that two-chain ...
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Dual roles of voltage gated sodium channels in development and cancer
... the persistent Na + current, which is typically a few per cent of the transient current, is likely to be predominant and may prove to be an important therapeutic target (Yang et ...
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Salt, sodium channels, and SGK1
... + channels (ENaCs), facilitate the bulk tran- sit of Na + across an epithelial ...These channels are not strictly regulated by membrane voltage, and other mechanisms have been found to modulate their activ- ...
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Firm Heterogeneity, Persistent and Transient Technical Inefficiency
... In a standard panel data model, the focus is mostly on controlling firm effects (heterogeneity due to unobserved time7invariant factors). This notion is adapted from the earlier panel data models (Pitt and Lee 1981; ...
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Sodium channels and mammalian sensory mechanotransduction
... gated sodium channels would suggest a role in mammalian mechano- ...both channels are dispensable for mechanically activated ...gated sodium currents in the ...
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Inhaled Nedocromil Sodium for Persistent Cough in Children
... There was no difference in the response to inhaled nedocromil sodium between children who had an established diagnosis of asthma receiving inhaled corticosteroids and those who did not ([r] ...
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The transient receptor potential family of ion channels
... TRP channels. (a) All channels contain six transmembrane segments (S1 to S6) with a putative pore region (P) between S5 and ...TRP channels and are only partially preserved within members of the same ...
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SDSS1133: an unusually persistent transient in a nearby dwarf galaxy
... While the expected properties of recoiling AGNs are poorly un- derstood, SDSS1133 does show many features similar to observed broad-line AGN and those expected for recoiling AGNs, includ[r] ...
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Voltage-gated sodium channels and metastatic disease
... 3. Regulation of intracellular Ca 2+ . In excitable cells, Na + current carried by VGSCs can result in an increase in intracellular Ca 2+ level, e.g. by activating voltage- gated Ca 2+ channels. 63, 64 Similar ...
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