competing endogenous RNA (ceRNA)
Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression
... Methods: Quantitative RT-PCR analysis was used to determine whether aberrant MEG3 expression was associated with GC patients pTNM stage and pM state. Furthermore, the effect of ectopic expression of MEG3 on cell ...
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Progress in Competing Endogenous RNA and Cancer
... of endogenous, non-coding 20 - 23 nucleotides RNA mo- ...non-coding RNA species, including small non-coding RNAs, pseudogenes, lncRNAs and circRNAs can act as miRNA “sponges” by sharing identical ...
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Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
... With technical progress in sequencing technologies, an increasing number of noncoding RNAs (ncRNAs) have been discovered in the last several years. Long ncRNA (lncRNA), > 200 nucleotides in length, has been reported ...
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<p>Long Noncoding RNA CCAT1 Functions as a Competing Endogenous RNA to Upregulate ITGA9 by Sponging MiR-296-3p in Melanoma</p>
... noncoding RNA (lncRNA) composed of more than 200 nucleotides in length and were commonly regarded as untranslational transcripts without protein- coding ...canonical competing endogenous RNA ...
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The lncRNA myocardial infarction associated transcript-centric competing endogenous RNA network in non-small-cell lung cancer
... Background: The leading cause of death for cancer is lung cancer, of which the majority sub- type is non-small cell lung cancer (NSCLC). Recent studies have shown long non-coding RNAs are transcribed and contribute to ...
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Long noncoding RNA <em>CRNDE</em> functions as a competing endogenous RNA to promote metastasis and oxaliplatin resistance by sponging miR-136 in colorectal cancer
... noncoding RNA (lncRNA) that is highly elevated in colorectal cancer and many other solid tumors but its functions on metastasis and oxaliplatin (OXA) resistance are ...a competing endogenous ...
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The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer
... Notes: (A) hgc-27 cells were transfected with negative control, siTincr, or siTincr + miR-375 inhibitor and injected subcutaneously into 10 nude mice per flank. Surgical resections of hgc-27 xenograft tumors on week 4 ...
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<p>Long Noncoding RNA <em>FGD5-AS1</em> Acts as a Competing Endogenous RNA on microRNA-383 to Enhance the Malignant Characteristics of Esophageal Squamous Cell Carcinoma by Increasing SP1 Expression</p>
... Methods: ESCC tissue samples and paired normal adjacent tissues were collected to quantify FGD5-AS1 expression by reverse-transcription quantitative PCR. The effects of FGD5-AS1 on ESCC cell proliferation, apoptosis, ...
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Long noncoding RNA SNHG6 functions as a competing endogenous RNA by sponging miR-181a-5p to regulate E2F5 expression in colorectal cancer
... Background: Long noncoding RNAs (lncRNAs) have been identified as a novel class of regulators implicated in diverse biological processes in human cancers. Currently, evidence have shown that SNHG6, a cancer-associated ...
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Competing endogenous RNA networks: tying the essential knots for cancer biology and therapeutics
... Several examples of MRE-containing non-coding RNA transcripts acting as ceRNAs have been described. This suggests that many long non-coding RNAs may poten- tially function as ceRNAs, and that the analysis of ceRNA ...
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Comprehensive analysis of a long noncoding RNA-associated competing endogenous RNA network in colorectal cancer
... In the present study, we identified DElncRNAs, DEmiRNAs, and DEmRNAs between CRC tissues and normal tissues, using a large cohort from the TCGA data- base. Then, an lncRNA–miRNA–mRNA ceRNA network was constructed, which ...
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C-Myc functions as a competing endogenous RNA in acute promyelocytic leukemia
... Based on the above knowledge, it could be speculated that let-7 family members probably would play a pivotal role through modulating the levels of c-Myc and other let-7-responsive genes to regulate the exquisite balance ...
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Biomarker and competing endogenous RNA potential of tumor-specific long noncoding RNA in chromophobe renal cell carcinoma
... exploring the prognostic roles and the competing endog- enous RNA potential of lncRNAs in chRCC. By analyz- ing the clinical information and large-scale sequencing data pertaining to a chRCC patient cohort, ...
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Identification and Analysis of P53-Mediated Competing Endogenous RNA Network in Human Hepatocellular Carcinoma
... as competing endogenous RNAs (ceRNAs) that compete to bind to shared microRNA (miRNA) recognition elements (MREs) to perform specific biological functions during ...p53-mediated RNA targets could ...
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The epithelial to mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network
... (MS2-based) RNA immunoprecipitations (22). Compared with MS2 RNA and a negative control miR (miR- 200b), an MS2-ITGA1 3′-UTR fusion transcript was significantly enriched in miR-181b (Figure ...
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LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d
... Rationale: Cardiac fibrosis is associated with various cardiovascular diseases and can eventually lead to heart failure. Dysregulation of long non-coding RNAs (lncRNAs) has recently been recognized as one of the key ...
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Small RNAs and the competing endogenous RNA network in high grade serous ovarian cancer tumor spread
... small RNA signature applicable to formalin-fixed paraffin-embedded (FFPE) tissues to diagnose these tumor spread ...depleted RNA and complete small RNA sequencing data, thus interrogating the ...
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Original Article Identification of potential prognostic biomarkers for gastric adenocarcinoma by constructing competing endogenous RNA network
... competitive endogenous RNA (ceRNA) ...non-coding RNA (lncRNA), microR- NAs (miRNAs), and mRNAs between gastric adenocarcinoma tissue samples and normal samples were selected using edger ...
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Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives
... Pandolfi et al. found that both PTEN and PTENP1 are both reduced in prostate cancer and that overexpression of PTENP1 increase the expression of PTEN and suppress tumor growth. Further they revealed that PTENP1 acts as a ...
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<p>Construction and Analysis of a Long Non-Coding RNA-Associated Competing Endogenous RNA Network Identified Potential Prognostic Biomarkers in Luminal Breast Cancer</p>
... The RNA-seq data and miRNA-seq data of luminal A breast cancer in the The Cancer Genome Atlas (TCGA) database were downloaded and compared with those in the miRcode database to obtain lncRNA – miRNA relationship ...
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