competing endogenous RNAs
The gain and loss of long noncoding RNA associated-competing endogenous RNAs in prostate cancer
... of competing endogenous RNAs (ceRNAs), which offers a novel viewpoint to elucidate the mechanisms of ...lncRNA-mRNA competing relationships, which may uncover new strategy for treating ...
11
Long non-coding RNAs in ovarian cancer
... It has been shown that diverse RNA molecules which harboring miRNA response elements (MREs) can act as competing endogenous RNAs (ceRNAs) [78]. CeRNA crosstalk represents a novel cluster of miRNA ...
13
C-Myc functions as a competing endogenous RNA in acute promyelocytic leukemia
... Recent reports have described a new post-transcriptional regulation that RNA transcripts can crosstalk with each other by competing for their common microRNAs. These RNA transcripts termed competing ...
9
<p>Long Non-Coding RNAs in Drug Resistance of Breast Cancer</p>
... non-coding RNAs (lncRNAs), which consist of more than 200 nucleotides, are a common type of ...as competing endogenous RNAs (ceRNAs), induce resistance in sensi- tive cells via exosomes, ...
13
Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks
... as competing endogenous RNAs (ceRNAs) or miRNA sponges, interacting with miRNAs in a manner that sequesters these molecules and reduce their regula- tory effect on target mRNAs ...
13
The epithelial to mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network
... Competing endogenous RNAs (ceRNAs) have binding sites for a common set of miRs and regulate each other’s expression by functioning as miR ...circular RNAs such as circRNA_100290 and ...
17
Identification and Analysis of P53-Mediated Competing Endogenous RNA Network in Human Hepatocellular Carcinoma
... non-coding RNAs (lncRNAs) and mRNA function as competing endogenous RNAs (ceRNAs) that compete to bind to shared microRNA (miRNA) recognition elements (MREs) to perform specific biological ...
9
LBX2-AS1 up-regulated by NFIC boosts cell proliferation, migration and invasion in gastric cancer through targeting miR-491-5p/ZNF703
... ceRNA: Competing endogenous RNAs; ChIP: Chromatin immuno- precipitation; DANCR: Differentiation antagonizing non-protein coding RNA; DMEM: Dulbecco’s modified eagle medium; ECL: Enhanced ...
11
Function and mechanism of long non-coding RNA Gm21284 in the development of hippocampal cholinergic neurons
... ceRNA: competing endogenous RNAs; CNS: central nervous system; EdU: 5-ethynyl-2′-deoxyuridine; EGF: epidermal growth factor; eRNAs: enhancer-associated RNAs; ESTs: expressed sequence tags; ...
12
The roles of lncRNA in hepatic fibrosis
... non‑coding RNAs; ECM: extracellular matrix; HSCs: hepatic stel‑ late cells; ceRNAs: competing endogenous RNAs; TGF‑β: transforming growth factor‑β; MALAT1: metastasis‑associated lung ...
8
Competing endogenous RNA networks: tying the essential knots for cancer biology and therapeutics
... These competing endogenous RNAs (ceRNAs), or natural miRNA sponges, have an active role in regulating miRNA availability within the cell and form intertwined regulatory ...messenger RNAs and ...
9
Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis
... circular RNAs (circRNAs) represent a typical class generated by back- splicing and characterized by covalently closed loop structures that lack either 5′ to 3′ polarity and a polyadenylated ...
18
<p>LINC00662 Long Non-Coding RNA Knockdown Attenuates the Proliferation, Migration, and Invasion of Osteosarcoma Cells by Regulating the microRNA-15a-5p/Notch2 Axis</p>
... Long non-coding RNAs (lncRNAs) are essential for the regulation of various cancers, including neuroblastoma, 9 breast cancer, 10 and OS. 11 The lncRNA LINC00662 (LINC00662) is 2085 bp long and is located at 19q11. ...
14
The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer
... Hence, it is of great importance to unravel the molecular switch controlling this malignant phenotype and elucidate the underlying mechanisms on the metastatic evolution of CRC. In particular, EMT is a powerful paradigm ...
13
<p>The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer</p>
... Extracellular vesicles (EVs) have been proved involved in transferring functional proteins and RNAs between cells and modulating recipient cell behaviors. 66 Some studies have proven that circRNAs can be enriched ...
17
Generation of measles virus defective interfering particles and their presence in a preparation of attenuated live-virus vaccine.
... These subgenomic RNAs, which interfered very efficiently with the replication of the endogenous standard genomes upon vaccine infection but showed a moderate interfering activity with a [r] ...
8
Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives
... non-coding RNAs of greater than200 nucleotides in ...non-coding RNAs that form a covalent closed loop by the direct ligation of 5’ and 3’ ends of linear RNAs [25], which are stable and present at ...
12
Poly(A)-Binding Protein Facilitates Translation of an Uncapped/Nonpolyadenylated Viral RNA by Binding to the 3′ Untranslated Region
... cis-Elements that mimic poly(A) tail in 3=CITE-dependent translation. The ARS dramatically enhanced 3=CITE-mediated translation in RCNMV RNA1. Other viruses with BTE-type 3=CITE also require additional sequences or ...
14
Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for hepatocellular carcinoma
... One ceRNA hypothesis was proposed by Salmena et al. [10]. A complicated posttranscriptional regulatory net- work was described that allowed lncRNAs, mRNAs, and other RNAs to compete with microRNAs (miRNAs) via ...
12
Modelling the structure of a ceRNA theoretical, bipartite microRNA–mRNA interaction network regulating intestinal epithelial cellular pathways using R programming
... Another layer of regulatory complexity consists of post-transcriptional regulation involving microRNA (miRNA)–messenger RNA (mRNA) target interactions. In addition to specific miRNAs associated with intestinal ...
7