competitive inhibition
Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model
... to competitive inhibition of endogenous survivin expression, which further leads to an increase in expression of pro-apoptotic proteins compared to anti-apoptotic proteins in the cytoplasm, which in turn ...
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Avidity and competitive inhibition of binding native and chaotropically modified immunoglobulins with protein and glycolipid antigens
... It is established, that native and chaotropi- cally modified immunoglobulins essentially differ by avidity and character of competitive inhibition of binding with protein (оvalbumin), glycolipid ...
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Management of L-dopa overdose in the competitive inhibition state
... the competitive inhibition ...the competitive inhibition state, this novel pill stop approach is required to prevent L-dopa overdose and to assist in identifying the optimal therapeutic dosing ...
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Molecular Insights into Function and Competitive Inhibition of Pseudomonas aeruginosa Multiple Virulence Factor Regulator
... a competitive inhibitor of ...and inhibition that could aid in the opti- mization of anti-MvfR compounds and improve our understanding of MvfR regula- ...
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An improved competitive inhibition enzymatic immunoassay method for tetrodotoxin quantification
... values of the standards are plotted against the log of the known concentration for each standard. Each sample starts with the letter S. Samples run without primary antibodies are used to[r] ...
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Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets
... the inhibition of isocitrate lyases by ...addition, competitive inhibition of isocitrate lyases along with a reduction in the inactivation of isocitrate dehydrogenases appears to be a feasible ...
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Uptake of materials by the intact liver The exchange of glucose across the cell membranes
... tionally characterize the transport process: phlorizin and Labeled red cells a vascular indicator, labeled sucrose galactose produced competitive inhibition; the transport an extracellul[r] ...
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Epitope specific antibody responses to virulent and avirulent feline infectious peritonitis virus isolates
... Monoclonal antibodies which recognized type-specific epitopes on each of the structural polypeptides of these two viruses were used in competitive-inhibition enzyme-linked immunosorbent [r] ...
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Binding of Quinoline Based Inhibitors to Plasmodium falciparum Lactate Dehydrogenase: A Molecular Docking Study
... owed significantly lower binding affinity than NADH. A closer look at the complexes formed show that NADH forms a significantly higher number of hydrogen bonds with the neighboring amino acid residues than any of the ...
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Recruitment of HIV 1 envelope occurs subsequent to lipid mixing: a fluorescence microscopic evidence
... the competitive inhibition approach in which a recombinant gp41 ectodomain devoid of the fusion peptide segment, termed gp41e, is added to the Env-expressing effector cell in the presence of the target cell ...
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IN VITRO ANTI CHOLINESTERASE ACTIVITIES BY PIPERINE, AN ALKALOID FROM THE SPICE FAMILY PIPERACEAE
... BuChE inhibition by piperine, concluding that it inhibits both cholinesterase enzymes and exhibits more selectivity toward ...demonstrates competitive inhibition for AChE and mixed-inhibition ...
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Modulation of the stability and activities of HIV-1 Tat by its ubiquitination and carboxyl-terminal region
... In our study, although the subcellular localization of Tat was not influenced by coexpression with various ubi- quitin mutants, the transactivation activity was affected to varying degrees. A previous study has reported ...
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Antibody to a recombinant merozoite protein epitope identifies horses infected with Babesia equi
... The antibodies were detected in a competitive inhibition enzymelinked immunosorbent assay CI ELISA by using monoclonal antibody 36/133.97, which defines a protein epitope on the merozoit[r] ...
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Dual integrin αvβ 3 and NRP 1 Targeting Paramagnetic Liposome for Tumor Early Detection in Magnetic Resonance Imaging
... and competitive inhibition assay showed the higher binding affinity of dual-targeted liposomes to HUVECs (human umbilical vein endothelial cells) and A549 cells compared with pure Gd-DTPA, non-targeted, and ...
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ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis
... the competitive inhibition of agonist binding to ERα, the inhibition of ER dimerization, nuclear transloca- tion and transcription activation through both AF-1 and AF-2, and increased ER protein ...
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Characterization of Aspergillus aculeatus β-glucosidase 1 accelerating cellulose hydrolysis with Trichoderma cellulase system
... saccharides of AnBGL was almost similar to AaBGL1 at each optimum pH condition (Seidle et al. 2004). Thus, we concluded that AaBGL1 has high saccharifying activity to- ward cellobiose compared with AnBGL, because AaBGL1 ...
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Inhibition of Human Erythrocyte Glucose 6-Phosphate Dehydrogenase by Cadmium, Nickel and Aluminium
... G6PD inhibition, therefore, may indicate Al (III) ...pure competitive inhibition observed by Al (III) with respect to glucose 6-phosphate seems surprising since these two molecules are not ...
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Parkinson’s disease-associated melanin steal
... the competitive inhibition state, then the primary force causing this phenomenon is melanin steal, which causes dopaquinone to preferentially utilize L-tyrosine and L-3,4-dihydroxyphenylalanine (L-dopa), ...
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Optimization of luminescent assay for screening of cyclin-dependent kinase 2 inhibitors
... Reactions were performed with reaction mixture containing 250 ng/ well CDK2/cyclin A, Histone H1 (2.5 mg/ml), ATP (100 μM), EDB (5 μL each), 25 μl Kinase-glo® Plus and with water (with blue symbol) and with EDB (with red ...
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Simple assay for staphylococcal enterotoxins A, B, and C: modification of enzyme linked immunosorbent assay
... Specificity of the triple-ball test: competitive inhibition of the uptake of the 100 g had been added gave positive results; i.e., enterotoxin-enzyme conjugate by the homologous 1 ng of [r] ...
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