Complementarity determining region
Homologous regions of autoantibody heavy chain complementarity determining region 3 (H CDR3) in patients with pemphigus cause pathogenicity
... Pemphigus is a life-threatening autoimmune disease in which antibodies specific for desmogleins (Dsgs) cause loss of keratinocyte cell adhesion and blisters. In order to understand how antibodies cause pathogenicity and ...
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Characterization of the immunoglobulin heavy chain complementarity determining region (CDR) III sequences from human B cell precursor acute lymphoblastic leukemia cells
... chain complementarity determining region (CDR)-III of B-lineage cells at various stages has provided important insights concerning B cell maturation and ...N region near the D ...
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Relationship between Antibody 2F5 Neutralization of HIV-1 and Hydrophobicity of Its Heavy Chain Third Complementarity-Determining Region
... external region (MPER) of the HIV-1 gp41 transmembrane glycoprotein is the target of the broadly neutralizing antibody ...third complementarity-determining region of the heavy chain (CDR H3) ...
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Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding
... this region of 2F5 might be involved in a secondary role other than core epitope binding (2, 18, 24, 28, 37, 41, ...in determining antigen specificity, is related to the type of antigen recognized: ...
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Molecular features of the complementarity determining region 3 motif of the T cell population and subsets in the blood of patients with chronic severe hepatitis B
... constant region of the beta chain (BC) and another primer or fluoro- genic probe directed towards the gene encoding the beta chain variable region (BV) ...
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Domain swapping of complementarity-determining region in nanobodies produced by Pichia pastoris
... with complementarity-determining regions (CDRs) against green fluorescent protein (GFP) or cluster of differentiation 4 (CD4) based on the scaffold of ...
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What you should know about PR3 ANCA: Structural aspects of antibodies to proteinase 3 (PR3)
... third complementarity-determining region (CDR3) residues of a human monoclonal anti-proteinase 3 (PR3) antibody contained many negatively charged aspartic acid residues, perhaps contributing to its ...
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Oligoclonal expansion of TCR Vδ T cells may be a potential immune biomarker for clinical outcome of acute myeloid leukemia
... the complementarity-determining region 3 (CDR3) sizes of eight TRDV subfamily genes were analyzed in γδ T cells sorted from peripheral blood mononuclear cells (PBMCs) from 30 patients with AML and 12 ...
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A complete, multi level conformational clustering of antibody complementarity determining regions
... antibody complementarity-determining region (CDR) conforma- tions is an important step that drives antibody modelling and engineering, prediction from sequence, directed mutagenesis and induced-fit ...
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Reduced T cell repertoire restrictions in abatacept treated rheumatoid arthritis patients
... by complementarity-determining region-3 (CDR3) spectra- typing after TCR beta variable (TCRBV) gene multiplex PCRs that allow the detection of 23 functional TCRBV families starting from 500 ng of ...
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Sequence analysis of T-cell repertoires in health and disease
... constant region (green) of the TCR is anchored to the cell membrane, followed by the J region ...J region is followed by the V region (orange), whereas in TCR β chains, a D region is ...
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IDENTIFICATION OF ANTIBODY TARGETS USING PHOTOACTIVATED CROSS LINKERS LOCATED IN THE BINDING SITE
... the complementarity determining region (CDR3) of the variable heavy (V H ) chain to allow the incorporation of the amber codon (TAG) in DNA and ...
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Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes
... (IGH) complementarity determining region 3 (CDR3) amino acid (AA) sequences shared across the pancreatic draining lymph node (pLN, yellow), spleen (blue), and “irrel- evant” mesenteric and/or ...
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The expanding array of HIV broadly neutralizing antibodies
... chain complementarity determining region (CDRH3) in what was termed a “hammerhead” structure to bind to the V1/V2 at the very top of the Env trimer where the three gp120 subunits meet to form the ...
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Bovine cryptosporidiosis: impact, host-parasite interaction and control strategies
... CDR: complementarity-determining region; cm: centimetre; DCs: dendritic cells; DNA: deoxyriboneucleic acid; GALT: gut associated lymphoid tissue; GM-CSF: granulocyte-macrophage colony-stimulating ...
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Public Infrastructure, Education, and Economic Growth: Region Specific Complementarity in a Half Century Panel of States
... For the education and infrastructure parameters, the GMM and OLS estimators yield roughly similar results. Given that the instruments are strong, with highly significant first-stage F-statistics, and that the J-statistic ...
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Determining the focal mechanisms of the events in the Carpathian region of Ukraine
... of determining parameters of the earthquake ...to determining the earthquake source parameters, based on the direct problem solutions, are ...Carpathian region of Ukraine are determined by the ...
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Stochastic complementarity
... Strikingly, the condition in the statement is an exact ordinal analog of the condition obtained for the ‘rationality limit’ of the logit case, in which the utility of a bundle σ is measured by (the opposite of) the ...
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Rapid detection of immunoglobulin heavy chain gene rearrangement by PCR and melting curve analysis using combined FR2 and FR3 primers
... rearranged processes during early B-cell development, creating a unique hallmark for each B-cell [5]. V seg- ments contain three framework regions (FRs) and two complementarity determining regions (CDRs). ...
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Complementarity in Time between Hydro, Wind and Solar Energy Resources in the State of Rio Grande do Sul, in Southern Brazil
... the complementarity between hydro, wind and solar pho- tovoltaic energy in the Brazilian state of Rio Grande do ...having complementarity between water, wind and solar photovoltaic schemes when ...
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