Concanavalin A-induced hepatitis
Derangements of liver tissue bioenergetics in Concanavalin A-induced hepatitis
... ConA-induced hepatitis is confirmed by the observation that mice lacking NK T cells and those treated with anti- IFN-γ antibody (to counter this essential inflammatory mediator released by NK T cells) are ...
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Original Article The water extract of Anoectochilus formosanus protects mice from concanavalin A-induced hepatitis
... Abstract: Anoectochilus formosanus, a famous traditional Chinese medicine, has been used as a source of folk medicine alternative liver injury therapy. Here, we evaluate the hepatoprotective potential of water extract of ...
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Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3
... To determine the effects of EGCG pretreatment on ConA- induced liver injury, the levels of ALT and AST in serum in each group were measured. We found that the levels of ALT and AST clearly increased following ConA ...
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Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis
... ditioning produces liver protective effects against hepatic ischemia/reperfusion injury in mice through activation of the PtdIns3K-AKT1 pathway. We have also observed in the present study that NaHS pretreatment ...
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Protective effect of galangin in Concanavalin A- induced hepatitis in mice
... Notes: (A) Molecular structure of galangin. (B) c57Bl/6 mice, n=5 per group, received vehicle or galangin (25 or 50 mg/kg) by intraperitoneal injection. Four hours later, galangin injection was repeated. control mice ...
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DNA BARCODING AND BIOLOGICAL ASSESSMENT ON A FEW MANGROVE PLANT SPECIES OF VISAKHAPATNAM COAST, ANDHRA PRADESH, INDIA
... of concanavalin-A is sufficient for the development of liver ...lesions. Concanavalin-A induced hepatitis is both T-cell and macrophage ...to concanavalin-A, a role has been envisaged ...
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Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice
... on hepatitis could be partly interrupted by an Akt kinase inhibitor, which supports our conclusion that ghrelin exerts its protective effect at least partly via the PI3K/Akt/Bcl-2 pathway (Figure ...
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Concanavalin A induced liver injury triggers hepatocyte proliferation
... In summary, this study demonstrates that Con A injection leads to apoptosis and hepatocyte proliferation. TNF controls nuclear C/EBP- b /LAP expression, and IL-6 activates STAT3/ APRF. Both events are found before the ...
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Paeoniflorin exerts a nephroprotective effect on concanavalin A-induced damage through inhibition of macrophage infiltration
... demonstrated that liver diseases with liver dysfunction, es- pecially in hepatic failure, are frequently accompanied by acute kidney injury (AKI) [13]. For example, renal damage consists of proximal tubular nephrosis in ...
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Mesenchymal stem cells overexpressing IL-35: a novel immunosuppressive strategy and therapeutic target for inducing transplant tolerance
... was induced to evaluate the effects of IL-35-MSCs on mur- ine immune ...in concanavalin A (Con A)-induced auto- immune ...induce hepatitis, and then they were divided into three groups and ...
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Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4<sup>+</sup>CD25<sup>-</sup>CD69<sup>+</sup> subset proliferation
... GA has been used as a liver-protection drug for several decades. Its new derivative, MGL was also used as a liver- protection drug in recent years. However, its effects on autoimmune liver injury and its potential ...
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Anti-hepatitis, antioxidant activities and bioactive compounds of Dracocephalum heterophyllum extracts
... Results: In the present study, the anti‑hepatics and antioxidant activities of four D. heterophyllum extracts (i.e. petro‑ leum ether extracts, ethyl acetate extracts, n‑BuOH extracts, and water extracts) were conducted. ...
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Manganese Superoxide Dismutase Therapy in a Murine Hepatitis Associated Injury
... A-induced hepatitis probably secondary to im- mune-mediated liver ...A-induced hepatitis in mice. We tested the hypothesis that Con A-induced hepatitis can be prevented by the ...
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NIMESULIDE INDUCED CHOLESTATIC HEPATITIS
... Non-steroidal anti-inflammatory drugs (NSAIDs) and antimicrobials are the most frequent cause of drug induced liver injury. 1 Like other NSAIDs, nimesulide, a unique molecule of the sulphonanilides class, has been ...
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Inactivation of Herpes Simplex Virus by Concanavalin A
... HSV-1, McIntyre VR 3 strain, and 1312 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The infectivity of' herpes simplex virus type 1 HSV-1 was inactivated after treatm[r] ...
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Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis
... CYP 2E1 is an endoplasmic monooxygenase and major source of oxidative stress in microsomes [159]. Overex- pression of CYP 2E1 is well recognized in the liver of patients with NASH [160] and CH-C [161] as well as ...
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HEPATOPROTECTIVE POTENTIAL OF ETHANOLIC EXTRACT OF SOLANUM MELONGENA LEAVES AGAINST ISONIAZID (INH) INDUCED LIVER DAMAGE IN ANIMAL MODELS
... Objective: To evaluate the hepatoprotective potential of ethanolic extract of Solanum Melongena leaves against Isoniazid (INH) induced liver damage in animal models. Methods: Six groups of six rats each were ...
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DIFFERENT MODELS OF HEPATOTOXICITY AND RELATED LIVER DISEASES: A REVIEW
... of hepatitis B and/or C can aid the development of hepatocellular carcinoma by repeatedly causing the body's own immune system to attack the liver cells, some of which are infected by the virus, others merely ...
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Bortezomib Induced Hepatitis B Reactivation
... for hepatitis B surface antibody (anti-HBs) and hepatitis B core antibody (anti-HBc) with negative hepatitis B surface antigen (HBsAg), which was indicative of her having a resolved ...infection. ...
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CLINICAL EVALUATION OF KODIPAVALA CHUNNAM IN THE TREATMENT OF INFECTIVE HEPATITIS, DRUG INDUCED HEPATITIS AND ALCOHOLIC HEPATITIS
... damaged, these enzymes released from the liver tissues and can be found in the blood. ALT is considered as more specific marker enzyme of hepatitis, because AST is also present in other organs such as heart and ...
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