Conserved serine
Highly conserved serine residue 40 in HIV 1 p6 regulates capsid processing and virus core assembly
... conserved serine residue at position 40, which until now has not been assigned to any known function of p6. Results: Consistently with previous data, we found that mutation of Ser-40 has no effect on ALIX ...
16
Phosphorylation of Highly Conserved Serine Residues in the Influenza A Virus Nuclear Export Protein NEP Plays a Minor Role in Viral Growth in Human Cells and Mice
... highly conserved serine residues S23 to S25 in the nuclear export protein (NEP) of influenza A viruses was suspected to regulate its nuclear export activity or polymerase activity-enhancing ...
6
Re visiting the functional Relevance of the highly conserved Serine 40 Residue within HIV 1 p6Gag
... Background: HIV-1 formation is driven by the viral structural polyprotein Gag, which assembles at the plasma membrane into a hexagonal lattice. The C-terminal p6 Gag domain harbors short peptide motifs, called late ...
5
The Conserved Serine 177 in the Delta Antigen of Hepatitis Delta Virus Is One Putative Phosphorylation Site and Is Required for Efficient Viral RNA Replication
... both serine and threonine ...of serine 177, which is conserved among all the known HDV strains, resulted in reduced phosphorylation of S-HDAg, while the mutation of the other two conserved ...
9
Directional Transneuronal Infection by Pseudorabies Virus Is Dependent on an Acidic Internalization Motif in the Us9 Cytoplasmic Tail
... Intracellular localization and internalization of mutant Us9 constructs. The phosphorylation status of the acidic internal- ization motif has been shown to be important for the intracel- lular trafficking of both the ...
13
Mutational Analysis of Hepatitis C Virus Nonstructural Protein 5A: Potential Role of Differential Phosphorylation in RNA Replication and Identification of a Genetically Flexible Domain
... highly conserved serine resi- dues at the N terminus of NS5A (S1975, S2010, and S2043) did not affect RNA replication significantly (data not ...secutive serine residues at positions 2200 to ...
8
The viral transactivator HBx protein exhibits a high potential for regulation via phosphorylation through an evolutionarily conserved mechanism
... the conserved serine, threonine, and tyrosine residues of HBx, we used several servers available on the web (Table ...the serine residues, the prediction of the phosphorylation scores was Ser75 > ...
9
The balance of Polo-like kinase 1 in tumorigenesis
... Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key ...
6
Human cytomegalovirus proteinase: candidate glutamic acid identified as third member of putative active-site triad.
... highly conserved domains (CD1 through CD5). An absolutely conserved serine in CD3 has been shown by site-directed mutagenesis of the simian cytomegalovirus (SCMV) and herpes simplex virus type 1 ...
5
Decreased expression of LKB1 predicts poor prognosis in pancreatic neuroendocrine tumor patients undergoing curative resection
... 11,12 LKB1 is a highly conserved serine/threonine kinase that directly phosphorylates a threonine residue at the activation loop of 14 kinases in the AMPK (AMP-activated kinase)[r] ...
7
The crystal structure and oligomeric form of Escherichia coli L,D carboxypeptidase A
... maximum resolution of only 2.54 Å. The trigonal crystals however proved robust to soaking with ethyl-mercury-p-toluenesulphanilide, allowing SAD phasing with a single dataset collected at BL5A using a wavelength of ...
25
EVIDENCE FOR THE INVOLVEMENT OF SERINE TRANSHYDROXYMETHYLASE IN SERINE AND GLYCINE INTERCONVERSIONS IN SALMONELLA TYPHIMURIUM
... As would be expected if strain JB561 contained two mutations, transductions with a proto- trophic strain as donor into strain JB561 gave all Ser+ transductants when the selecti[r] ...
14
Induction of serine racemase expression and D-serine release from microglia by amyloid β-peptide
... We next tested whether D-serine played a requisite role in the neurotoxicity exhibited by Aβ-treated microglia. Pri- mary microglia were left untreated or were exposed to Aβ overnight. Conditioned medium from ...
11
Influenza C virus esterase: analysis of catalytic site, inhibition, and possible function.
... Comparisons of sequences around active site serine residues in serine hydrolases Enzyme source Serine esterases HE influenza virus C/JHG/66 Acetylcholinesterase torpedo Butyrylcholineste[r] ...
7
Sarcoptes scabiei: genomics to proteomics to biology
... various serine proteases of ...trypsin-like serine proteases, five of 10 serine protease-like proteins and two of the 18 Sar s 3 serine protease-like proteins had intact catalytic triads while ...
13
Ion-Solvent Interactions Studies Of Molecular Interactions In Mixed Aqueous Systems By Ultrasonic Velocity At Different Temperatures
... specific composition, where the acoustic parameter becomes either maximum or minimum. This is the stage where complex formation is taking place in the system due to increased ion – solvent interaction. In (water + NaCl + ...
16
Gut microbiota–derived D-serine protects against acute kidney injury
... The activity of SRR in the kidney homogenates was determined by a colorimetric method that mea- sured 2-oxo acid production from L-THA (40) because the production of D-serine from L-serine (or vice versa) ...
17
Autosomal Dominant Hypercalciuria in a Mouse Model Due to a Mutation of the Epithelial Calcium Channel, TRPV5
... (Figure S1A–D). In addition, Ca 2+ dependent inhibition of Na + currents was similar between TRPV5-WT and TRPV5- S682P (Figure S1E and F). The absence of any effect by the mutant may again be due to overexpression of ion ...
14
Akt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical region
... sites conserved in both species, while phospho-amino acid analysis identifies the targeted residues as serine rather than ...this serine was ...
18
The cloning and characterisation of link1: A LIM-domain containing protein kinase
... Irrespective of the effect that the LIM domains may have, Lim kl itself may also be regulated through phosphorylation by other kinases involved in signal transduction. Putative recognition motifs for casein kinase 1 and ...
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