Constitutive activation
Constitutive activation of 5 lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis
... the constitutive activation of the 5-LO pathway in lung tissue from IPF patients might be associated with a similar accumulation of 5-LO protein at the nuclear en- velope of the cell type or types ...
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Mutations in conserved regions of eel luteinizing hormone receptor result in constitutive activation or inactivation
... induce constitutive activation or impaired signal transduction in eelLHR consistent with previously reported mammalian LHR mutations that cause FMPP and elevated cAMP levels in the absence of ...
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Constitutive activation of WASp in X linked neutropenia renders neutrophils hyperactive
... The gene encoding WASp is uniquely expressed in hematopoietic cells and highly expressed during neutrophil maturation (Immgen. org). WASp is critically dependent on its structural conformation for activity and is ...
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Both the Polycythemia- and Anemia-Inducing Strains of Friend Spleen Focus-Forming Virus Induce Constitutive Activation of the Raf-1/Mitogen-Activated Protein Kinase Signal Transduction Pathway
... that constitutive activation of the Raf-1/MAP kinase pathway by the virus may result in deregulation of AP-1 ...the constitutive activation of signal transduction molecules in both the ...
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Original Article Constitutive activation of nuclear factor-kappa B (NF- (B) signaling pathway in fibrolamellar hepatocellular carcinoma
... constitutive activation is related to progression of various malignant neoplasms ...now, activation status of NF-κB and its signaling pathway in FLHCC has not been ...if activation of the ...
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Constitutive activation of a variant of the env-mpl oncogene product by disulfide-linked homodimerization.
... the constitutive activation of this truncated cytokine receptor and found that the rearrangement of the env sequences in the env-mpl fusion gene was not required for ...
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Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma
... This constitutive Stat1 signal may lead to overexpression of a subset of epithelial immune- response genes, including ICAM-1, Stat1, and IRF-1 transcription factor (15–18, 23), and a condition of per- sistent ...
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Replicating Adenoviruses That Target Tumors with Constitutive Activation of the wnt Signaling Pathway
... with activation of the wnt ...fibroblasts. Activation of wnt signaling by transduction of a stable  -catenin mutant into normal fibroblasts renders the cells permissive for virus ...
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Positive and negative regulation of cortical cell division during root nodule development in Lotus japonicus is accompanied by auxin response
... that activation of AON-related CLE genes occurs downstream of ...certainly, constitutive activation of LjCLE-RS genes has no effect on nodulation in har1 mutant plants (Nishimura et ...
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Melanocortin 4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
... melanocortin-4 receptor (MC4-R) is a key element in the hypothalamic control of food intake. Inactivation of the gene encoding this G protein–coupled receptor causes obesity in mice. In humans, frameshift mutations in ...
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The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells
... a constitutive activation of the MAPK pathway mainly dependent on the autocrine activation of FGFR1; in fact, untreated MM1 cells release high levels of bFGF, reaching concentrations about 30-fold ...
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The GanB Gα-Protein Negatively Regulates Asexual Sporulation and Plays a Positive Role in Conidial Germination in Aspergillus nidulans
... domain constitutive activation of GanB caused decreases in cell (Figure 1) has been proposed to act as a hinge involved mass and radial extension to 69 and 74% of wild type, respectively (Figure 2 and Table ...
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ASSOCIATION LUPUS AND TUBEROUS SCLEROSIS: IS IT POSSIBLE? THE INVOLVEMENT OF MTOR PATHEWAY
... and activation of the mammalian target of rapamycin (mTOR) ...pathway. Constitutive activation of mTOR signaling has recently been reported in systemic lupus erythematosus (SLE), and inhibition of ...
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Polyomavirus Large T Antigen Induces Alterations in Cytoplasmic Signalling Pathways Involving Shc Activation
... for constitutive Shc phosphorylation is that the interaction of LT with Shc is responsible for a deregulated kinase activity on the adapter molecule or, alternatively, for interference with the Shc ...
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Mechanisms of AXL overexpression and function in Imatinib- resistant chronic myeloid leukemia cells
... AXL is a receptor tyrosine kinase of the TAM family, the function of which is poorly understood. We previously identified AXL overexpression in Imatinib (IM)-resistant CML cell lines and patients. The present study was ...
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Stat proteins and oncogenesis
... its constitutive activation and subsequent trans- formation of ...STAT3 activation is typ- ically dependent upon dysregulated growth factor receptor tyrosine kinases or their associated Jak kinas- ...
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Potential use of STAT3 inhibitors in targeted prostate cancer therapy: future prospects
... the activation of STATs is tightly regulated and ...stitutive activation of STATs has been associated with the malignant ...state. Constitutive activation of STAT3 in par- ticular has been ...
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The malignant potential of HIV-associated Kaposi sarcoma
... Through constitutive activation of intracellular signaling pathways, vGPCR has the capacity to transform endothe- lial cells by promoting their uncontrolled proliferation and by inhibition of apoptosis ...
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MiR 506 Promotes Natural Killer Cell Cytotoxicity against Human Hepatocellular Carcinoma Cells by Targeting STAT3
... Constitutive activation of STAT3 is observed in diverse human tumors, and STAT3 has been reported to mediate the crosstalk between tumor and immune cells.23 Moreover, aberrant activation[r] ...
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Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells
... JAK2 activation, are widely observed in hematological malignancies, comparable mutations have not been detected in solid ...maintain constitutive activation of JAK2/STAT3 signaling remains ...
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