Control of the Cell Cycle
CYCLIN DEPENDENT KINASES AND CELL CYCLE CONTROL
... AND CONTROL OF THE CELL CYCLE The most important events of the cell cycle are those concerned with replica- tion of the genome and segregation of the replicated genomes into the ...
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Topology and Control of the Cell-Cycle-Regulated Transcriptional Circuitry
... of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037 ABSTRACT Nearly 20% of the budding yeast genome is transcribed periodically during the cell division ...the ...
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Nek family of kinases in cell cycle, checkpoint control and cancer
... Summary Early phenotypic analyses of the mutant fungi for the archetypal Nek kinase revealed their involvement in cell cycle regulation. Subsequent studies in yeast and frogs, and more recently mice, have ...
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Developmental Control of the Cell Cycle: Insights from Caenorhabditis elegans
... how cell proliferation is regulated to produce the invariant cell ...lineage. Cell cycle regulators that are required to allow the proper cell lineage have been identified, and ...
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THE ROLE OF P38 MAPK IN CELL CYCLE CHECKPOINT CONTROL FOLLOWING DNA DAMAGE
... the control of the cell cycle specifically at the G2 to M transition point and in other aspects of p38’s role in DNA damage ...the control of cell cycle progression specifically ...
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Cell cycle control and cancer
... p57 KIP2 can bind to a much broader range of Cdks that includes Cdk4, Cdk6, Cdk2 and Cdc2 (ref. 22, Figure 2). Now, although the CIP/KIP family were originally identi- fied as Cdk inhibitors, it has recently come to ...
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Myc and cell cycle control
... to cell proliferation. The entry in cell cycle of quiescent cells upon Myc enforced expression have been described in many ...of cell cycle ...on cell cycle ...of ...
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A Journey in Science: Cell-Cycle Control
... their cell cycle more rapidly than they could grow, and as a consequence were being advanced prematurely through a rate- limiting process of the cell cycle that was controlling the overall ...
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Switching the Cell Cycle. Kip-Related Proteins in Plant Cell Cycle Control 1
... the Cell Cycle? In animals, CKIs might also have functions outside the cell cycle, such as in differentiation, morphogen- esis, and programmed cell ...socket cell fate (Weinl et ...
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CiteSeerX — The Retinoblastoma Protein and Cell-Cycle Control
... One observation suggests that pRB and, by extension, the E2F transcription factors under its immediate control play a more central role in controlling cell cycle progres- sion [r] ...
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Cell Cycle Control 116. Tumor Suppressors Prevent Uncontrolled Cell Division. Regulation of the Cell Cycle: A Closer Look
... The causes of Lance Armstrong’s cancer are not as clear-cut as Jolie’s genetic predisposition. His family history of cancer is not nearly as pro- nounced as hers, so his cancer could have developed in response to some ...
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The ubiquitin-proteasome system in glioma cell cycle control
... several cell cycle proteins rather than cover all aspects of cell cycle events being under the control of UPS in malignant gliomas, as well as of the complexity and ex- tent of this ...
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Anticancer drug targets: cell cycle and checkpoint control
... checkpoint control, resulting in aberrant respons- es to cellular ...triggers cell cycle arrest or apoptosis, depending on the degree of damage and the cellular ...context. Cell cycle ...
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Identification of Deubiquitinating Enzymes that Control the Cell Cycle in Saccharomyces cerevisiae
... Identification of Deubiquitinating Enzymes that Control the Cell Cycle in Saccharomyces cerevisiae Claudine E.. Mapa University of Massachusetts Medical School.[r] ...
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JAB1/CSN5: a new player in cell cycle control and cancer
... Abstract c-Jun activation domain-binding protein-1 (Jab1) acts as a modulator of intracellular signaling and affects cellular proliferation and apoptosis, through its existence as a monomer or as the fifth component of ...
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A central role for TRPS1 in the control of cell cycle and cancer development
... eukaryotic cell cycle is controlled by a complex regulatory network, which is still poorly ...modulates cell proliferation and controls cell cycle ...key cell ...
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Viral cyclin disruption of mammalian cell cycle control mechanisms.
... eukaryotic cell division know n as the "cell cycle". Study of the cell cycle is central to cancer evolution as all hum an m alignancies exhibit m ajor d isru p tio n s in the ...
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Control the Host Cell Cycle: Viral Regulation of the Anaphase-Promoting Complex
... the cell cycle during infection and some of them cause tumors, it is not surprising that the APC would be targeted by ...to control the APC and identify questions that need to be addressed in future ...
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Investigating E2F independent cell cycle control and tumor suppression by pRB
... of cell cycle control through the disruption of E2F driven transcription, codeletion of E2f1 or E2f3 with Rb1 loss, partially rescued pRb deletion resulting in prolonged viability of embryos ...
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Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control
... towards cell cycle regulation. SAOS2 cell cycle arrest assays showed that disruption of three separate binding surfaces were necessary to inhibit pRB-mediated cell cycle ...to ...
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