COP9 signalosome
Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway
... The COP9 signalosome (CSN) is a highly conserved protein complex, consisting of 8 subunits designated CSN1-CSN8 in higher eukaryotes [1–3]. Six subunits (CSN1, −2, −3, −4, −7 and −8) contain a proteasome, ...
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Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers
... (COP9) signalosome (CSN), a protein complex involved in embryonic development, is implicated in cell cycle regulation and the DNA damage ...the COP9 subunit 6 (CSN6) gene is amplified in human breast ...
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COP9 signalosome subunits protect Capicua from MAPK dependent and independent mechanisms of degradation
... The COP9 signalosome promotes Capicua accumulation Upon binding of the ligand Spi to the EGFR, the GTP-bound form of Ras activates the protein kinase Raf, initiating a phosphorylation ...that COP9 ...
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Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
... Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 from activated Cullins. Here we ...
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COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer
... Cervical cancer is one of the leading causes of cancer death in women. Human papillomaviruses (HPVs) are the major cause in almost 99.7% of cervical cancer. E6 oncoprotein of HPV and E6-associated protein (E6AP) are ...
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PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome
... ABSTRACT Epithelial cell differentiation and polarized migration associated with epithelial- to-mesenchymal transition (EMT) in cancer requires integration of gene expression with cytoskeletal dynamics. Here we show that ...
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The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability
... The COP9 signalosome (CSN) was originally identified based on mutants with a constitutive photomorphogenic (cop) phenotype in Arabidopsis thaliana seedlings (Wei et ...
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Regulation of SCF ubiquitin ligases by Jab1/Csn5 and the Cop9 signalosome
... The Cop9 Signalosome (CSN) can promote the removal of the ubiquitin-like protein Nedd8 from Cul1; however the molecular basis behind this activity is ...
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Mechanistic Dissection of the Cop9 Signalosome’s Deneddylation Activity on Cullin-RING Ligases
... the Cop9 Signalosome was the inability of seedlings to not sprout under dark ...(Proteasome, Cop9, Initiation Factor 3) or an MPN domain (Mpr1p and Pad1p N- ...
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The COP9 signalosome subunit 6 (CSN6): a potential oncogene
... (COP9) signalosome (CSN), which is an evolutionarily conserved multiprotein complex found in plants and animals and originally described as a repressor of light-dependent growth and transcription in ...
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Mycobacterium tuberculosis Alters the Metalloprotease Activity of the COP9 Signalosome
... Modulation of CSN5 function most likely protects M. tuber- culosis effectors from Ub degradation. The most-characterized biological process that the COP9 signalosome regulates via JAMM of CSN5 is the ...
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Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline
... COP-9 signalosome (CSN) complex [69], while the other members of the family are deubiquitinating enzymes that preferentially cleave lysine 63-linked polyubiquitin ...
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COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex
... To examine the performance of a new steady state of endogenic Cul1 neddylation status in the presence of simultaneous neddylation and deneddylation reactions, we conducted a time plot[r] ...
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The csnD/csnE Signalosome Genes Are Involved in the Aspergillus nidulans DNA Damage Response
... proteasome, COP9 signalosome, initiation factor 3/proteasome subunits, Int-6, Nip-1, and TRIP-15 (PCI/PINT) and the Mrp1p, Pad1 N-terminal family (MPN/MVO34) protein domains (G lickman et ...
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GLH 1, the C elegans P granule protein, is controlled by the JNK KGB 1 and by the COP9 subunit CSN 5
... The GLHs (germline RNA helicases) are constitutive components of the germline-specific P granules in the nematode Caenorhabditis elegans and are essential for fertility, yet how GLH proteins are regulated remains ...
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A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast
... The genetic screen reported here uncovered several novel factors affecting heterochromatin integrity in fission yeast. We identified known and newly-characterised splicing fac- tors that support processing of ...
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The Id-protein family in developmental and cancer-associated pathways
... the COP9 signalosome (CSN) subunits CSN5 and CSN7 [78], the deubiquitinase USP1 [79], the Apc/C subunits Apc1, Apc5, Apc8/Cdc23 [50], the cell-membrane protein caveolin-1 [80], the four-and- a-half LIM-only ...
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COP9 Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary
... Both COP9 and Hh signaling are dispensable for pERK and dally expression in ...that COP9 controls Hh signaling in ECs, which in turn regulates GSC lineage differentiation by repressing BMP signaling and ...
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p130Cas Scaffolds the Signalosome To Direct Adaptor-Effector Cross Talk during Kaposi's Sarcoma-Associated Herpesvirus Trafficking in Human Microvascular Dermal Endothelial Cells
... trafficking signalosome in endothelial cells and suggest that simultaneous targeting of KSHV entry receptors with p130Cas would be an attractive potential avenue for therapeutic intervention in KSHV ...
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Proteomic analysis of short term preload induced eccentric cardiac hypertrophy
... b Representative Western blots showing change in the expression of 60 kDa heat shock protein, mitochondrial HSPD1, Polymerase I and transcript release factor PTRF, ß-enolase Eno3, COP9 s[r] ...
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