Core promoter
Genetic variability in the precore and core promoter regions of hepatitis B virus strains in Karachi
... Double mutation may enhance viral replication [13]. In our study most of the patients had HBV mutations at more than one sites. Twelve (17%) HBeAg negative patients had dual T1762 and A1764 mutations. None of the HBeAg ...
6
Transactivation of the Hepatitis B Virus Core Promoter by the Nuclear Receptor FXRα
... Following the demonstration of the essential role of NR in the HBV life cycle, NR agonists and antagonists were envis- aged as possible new therapeutic targets against HBV. Bile acids were recently shown to enhance ...
9
Influence of Hepatitis B Virus X and Core Promoter Mutations on Hepatocellular Carcinoma among Patients Infected with Subgenotype C2
... predictive factors for HCC in the multivariate analyses. The T1653 mutation was first found in fulminant hepatitis patients (15, 33, 48) and in cases of chronic hepatitis with acute exac- erbation (32). Some studies ...
7
Clinical Significance of Hepatitis B Virus (HBV) Genotypes and Precore and Core Promoter Mutations Affecting HBV e Antigen Expression in Taiwan
... Of the 200 patients, 131 were infected with genotype B and 66 were infected with genotype C. Compared with the geno- type B-infected patients, the genotype C-infected patients had a higher incidence of liver cirrhosis ...
7
ZEB2 inhibits HBV transcription and replication by targeting its core promoter
... mRNA, core protein level, and the secretion of HBsAg and ...HBV core promoter and inhibit its promoter ...HBV core promoter eradicated ZEB2-mediated inhibition of HBV ...
9
The JC virus minimal core promoter is glial cell specific in vivo.
... affinity Tst-1 binding site has not been linked to repressor function (28). Moreover, it has been suggested that the inter- action of Tst-1 with DNA may be less essential than its inter- actions with proteins that ...
9
Overlapping initiator and TATA box functions in the basal core promoter of hepatitis B virus.
... FIG. 1. Mapping of the initiation sites of precore and pregenomic RNAs. (A) Schematic diagram of the wild-type (pCp1636-1851HBs) and pCp1636-1851‘‘t’’HBs constructs containing the core promoter with the ...
11
Characterization of the minute virus of mice P38 core promoter elements.
... the core promoter elements of P38 and the constitutively expressing P4 ...P38 core promoter elements with those from constitutively expressing MVM P4 or simian virus 40 (SV40) promoters did ...
8
Mutations in the Basal Core Promoter and Precore/Core Regions of Hepatitis B Virus in Patients Co-Infected With Human Immunodeficiency Virus
... The core promoter (CP, nt1575-1849) of the viral genome plays a significant role in HBV replication as it directs initiation of transcription for the synthesis of both the PC and pre-genomic (pg) ...basal ...
8
Hepatitis B Virus Genotype C Isolates with Wild-Type Core Promoter Sequence Replicate Less Efficiently than Genotype B Isolates but Possess Higher Virion Secretion Capacity
... wild-type core promoter sequence, and one had the classic A1762T/G1764A double ...The core promoter (CP) mutations of these isolates are ...
11
Core Promoter Structure in the Oomycete Phytophthora infestans
... the core promoter structure of the oomycete Phytophthora ...(nt) core sequence that overlaps the TSS in most oomycete genes. The core promoter regions of Piexo1 and Piendo1 were ...
9
Core Promoter Sequences Contribute to ovo-B Regulation in the Drosophila melanogaster Germline
... this core response to OVO-A ...the core promoter and promotes preinitia- factors, as the otu promoter, a direct target of ovo, is tion complex formation (Lu and Oliver ...ovo-B core of ...
12
Core promoter acetylation is not required for high transcription from the phosphoenolpyruvate carboxylase promoter in maize
... Pepc promoter in maize, particularly as transcription is not activated from the minimum level, but from an interme- diate state (Figures 1 and ...Pepc core promoter whether or not transcription is ...
11
Naturally Occurring Mutations Define a Novel Function of the Hepatitis B Virus Core Promoter in Core Protein Expression
... Core promoter mutations have been associated with more aggressive disease, including fulminant hepatitis (2, 9, 31, 34, ...in core protein expression and increased replication could potentially play ...
11
In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation.
... The Cp activity is detectable only in the liver of the PEX7 line, in which enhancer I is present, whereas it is active in various tissues of the SV28 and AX lines, which lack this enhancer (Table 1). The results ...
5
Investigating the Protective Effects of Telomerase Reverse Transcriptase on Neuronal Metabolism and Resistance to Amyloid-beta
... Cloning of Human Telomerase Catalytic Subunit (hTERT) Gene Promoter and Identification of Proximal Core Promoter Sequences Essential for Transcriptional Activation in Immortalized and [r] ...
82
A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria
... the core consensus sequence for one of 4 Sp1 binding sites in the core hTERC promoter ...hTERC promoter-luci- ferase constructs confirmed that this site is a functional regulator of hTERC ...
8
Determinants for the Occurrence of Acute Exacerbation of Hepatitis B Virus Infection in Chinese Patients after HBeAg Seroclearance
... ble chances of acute exacerbation and comparable prevalences of precore and core promoter mutations. Most of these pa- tients received interferon therapy ⬃ 6 years before HBeAg seroclearance. These results ...
6
Clinical and Serological Variation between Patients Infected with Different Hepatitis B Virus Genotypes
... the core promoter, precore, and S regions and comparing key nucleotide positions with those from genotyp- ically well defined strains after alignment of the ...
5
The Rous Sarcoma Virus Long Terminal Repeat Promoter Is Regulated by TFII-I
... HIV-1 promoter has been shown to bind TFII-I (59). The HIV-1 core promoter lacks a prototypical Inr but does contain an SSR that influences pro- moter strength, similar to the RSV ...KDR/flk-1 ...
9