COX-1
Exploring Structural Parameters for Designing Cox 1 and Cox 2 Inhibitors: Pharmacophoric Modeling, Virtual Screening and Docking Study
... Cyclooxygenase-1 (COX-1) and Cyclooxygenase (COX-2) are the two major isoforms of cyclooxygenase responsible mainly for production of prostaglandins. The produced prostaglandins exert function ...
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Docking Studies of the Derivatives of 3 oxamoyl(succinoyl)amides of N Phenylanthranilic Acids as Inhibitors of Enzymes COX 1 and COX 2
... and COX-2 [3,4]. COX-1 is a constitutive form of the enzyme contained in almost all tissues and cells of the body and regulates the processes of the synthesis of homeostatic and cytoprotective ...
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QSAR Study of 4-Benzylideneamino-Benzenesulfonamides and 4-Phenyliminomethyl-Benzenesulfonamides as Selective Cox-1 and Cox-2 Inhibitors
... the COX-2 selective inhibitor NSAID drugs were thought to be a major breakthrough, with the Expectation of a significant reduction in gastrointestinal (GI) side ...effects. COX-2 is induced in response to ...
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Synthesis, Biological Evaluation, and Docking Analysis of Methyl Hydroquinone and Bromo Methyl Hydroquinone as Potent Cyclooxygenase (COX-1 and COX-2) Inhibitors
... vitro COX-1/COX-2 inhibition studies showed that compound 2 was a more potent COX inhibitor than compound ...both 1 and 2 fitted into the active site and interacted with protein amino ...
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Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population
... diabetes, COX gener- ates prostaglandins, which negatively modulate glucose- stimulated insulin ...that COX may associate with diabetes ...that COX-1 rs1330344 and COX-2 (rs20417, ...
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Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney
... the COX-1 dependent RAAS response to volume depletion was blunted with ketoprofen, accounting for the lesser effect of robenacoxib on furosemide-induced PRA ...
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Niacin and biosynthesis of PGD2 by platelet COX 1 in mice and humans
... Furthermore, COX inhibitors in humans, as well as platelet depletion, COX-1 knockdown, and COX-2 deletion in mice, revealed that nia- cin evoked platelet COX-1–derived PGD 2 ...
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Combined activity of COX-1 and COX-2 is increased in non-neoplastic colonic mucosa from colorectal neoplasia patients
... Denmark): COX-1 forward (5’-GAGCAGCTTTTCCAG ACGA -3′); COX-1 reverse (5′- TCCTCGATGACAATC TTGATG -3′); COX-2 forward (5′- ACTAGAGCCCTT CCTCCTGTG -3′); COX-2 reverse (5′- ...
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Use of Propolis in Cancer Research
... Propolis has been reported to produce anti- inflammatory activity both in vitro and in vivo by the inhibition of proinflammatory cytokines and increase of anti-inflammatory cytokines 109,110. It may inhibit the ...
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Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP 1 human macrophages: a possible mechanism for increased cardiovascular risk
... system. COX enzymes catalyze the rate-limiting step in the prostanoid biosynthesis pathway, converting arachidonic acid into the chemically unstable intermediate PGH 2 , from which prostag- landins and ...
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Activity and potential role of licofelone in the management of osteoarthritis
... Abstract: Osteoarthritis is the most common form of arthritis. It is a progressive joint dis- ease associated with aging. It may be found in the knees, hips, or other joints. It is estimated that costs associated with ...
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Assessment of cyclooxygenase-1 and 2 gene expression levels in chronic autoimmune thyroiditis, papillary thyroid carcinoma and nontoxic nodular goitre
... of COX-2 enzyme in inflammatory processes of the thyroid have recently become a subject of interest for ...of COX-1 and COX-2 gene in the fine needle aspiration biopsy (FNAB) washouts and in ...
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Cyclooxygenase 1 and 2 expression in rheumatoid synovial tissues Effects of interleukin 1 beta, phorbol ester, and corticosteroids
... both Cox-1 and -2 under basal conditions in freshly explanted rheumatoid synovial ...of Cox-2 polypeptide was enhanced by IL-1 beta or PMA, and dramatically suppressed by dexamethasone ...
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Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production
... of COX-1/2 mRNA and proteins were increased in response to PSaV infection, so we evaluated the effects of COX-1-specific, COX-2- specific, and nonselective COX-1/2 ...
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Cat’s whiskers (Orthosiphon stamineus) tea modulates arthritis pathogenesis via the angiogenesis and inflammatory cascade
... Results: Treatment with EOS resulted in dose-dependent inhibition of paw edema in acute and chronic models of inflammation. It also inhibited significantly the production of TNF- α , IL-1 COX-1, and ...
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Anti inflammatory effects of Polygonum minus (Huds) extract (Lineminus™) in in vitro enzyme assays and carrageenan induced paw edema
... result suggests that Polygonum minus extract does not have the ability to modulate the generation of AA from membrane phospholipids produced by the destruction of tissue. Instead, it appears that Polygonum minus extract ...
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STUDY OF CYCLOOXYGENASE 3 ON THE BASES OF ITS FACTS AND CONTROVERSIES
... probable COX-active protein 29 ...of COX-1 mRNAs, suggests, that they might be translated in the earlier uncharacterized COX-1 associated proteins, a key protein product as ...the ...
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Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase 1
... of Cox-1 in the regenerating crypts by irradi- ation could either be due to a direct effect of radiation-injury on the stem cells, or to an indirect effect mediated by the radi- ation-induced production of ...
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Cyclooxygenase selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read outs
... of COX-2. These considerations also greatly diminish the likelihood of COX-independ- ent effects of aspirin contributing to the apparent pro- tection against colorectal cancer, because of the marked- ly ...
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New functions for Cox 2 in health and disease: Report of “The Third International Workshop on Cox 2”, Ka’upulehu, Kona, Hawaii, USA, 30 August to 2 September 1999
... the Cox enzymes has been known in principle for a few years, several function- ally important features still remain to be ...The Cox-2 enzymatic channel is wider than that of Cox-1, and it has ...
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