COX-1/-2
QSAR Study of 4-Benzylideneamino-Benzenesulfonamides and 4-Phenyliminomethyl-Benzenesulfonamides as Selective Cox-1 and Cox-2 Inhibitors
... of COX enzyme as a highly suitable target in anti-inflammatory ...therapy 1 . Although COX-2 is concerned to be the main isoenzyme related to inflammation, most NSAIDs in the market today ...
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Expression of COX-1, COX-2, 5-LOX and \(\hbox {CysLT}_2\) in nasal polyps and bronchial tissue of patients with aspirin exacerbated airway disease
... reduced COX-2 protein expression in nasal polyps of AIA patients, Pujols et ...of COX-2 expression in nasal tissue of AIA and ATA patients, that the baseline concentrations of ...
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Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney
... of COX-1 and COX-2 primary antibodies, ...with COX-1 (160108, Cayman Chemical, Camdridge, UK) or COX-2 (sc-1745, Santa Cruz Biotechnology) primary antibodies at ...
11
Combined activity of COX-1 and COX-2 is increased in non-neoplastic colonic mucosa from colorectal neoplasia patients
... detected tuft cells as also concluded in several mouse colon studies with COX-1 immunostaining [12, 29–31]. These cells (also known as brush cells) have previously been found in endoderm-derived epithelia ...
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Exploring Structural Parameters for Designing Cox 1 and Cox 2 Inhibitors: Pharmacophoric Modeling, Virtual Screening and Docking Study
... Pharmacophore investigation is measured as an essential segment of drug design. The pharmacophore generated by Ligand Scout for reference ligands for PDB ID: 3N8X and 1PXX for COX-1 and COX-2 ...
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Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population
... type 2 diabetes, COX gener- ates prostaglandins, which negatively modulate glucose- stimulated insulin ...that COX may associate with diabetes ...type 2 diabetes ...that COX-1 ...
12
Docking Studies of the Derivatives of 3 oxamoyl(succinoyl)amides of N Phenylanthranilic Acids as Inhibitors of Enzymes COX 1 and COX 2
... and COX-2 [3,4]. COX-1 is a constitutive form of the enzyme contained in almost all tissues and cells of the body and regulates the processes of the synthesis of homeostatic and cytoprotective ...
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Synthesis, Biological Evaluation, and Docking Analysis of Methyl Hydroquinone and Bromo Methyl Hydroquinone as Potent Cyclooxygenase (COX-1 and COX-2) Inhibitors
... vitro COX-1/COX-2 inhibition studies showed that compound 2 was a more potent COX inhibitor than compound ...both 1 and 2 fitted into the active site and interacted ...
5
Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production
... of COX-1/2 mRNA and proteins were increased in response to PSaV infection, so we evaluated the effects of COX-1-specific, COX-2- specific, and nonselective ...
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A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood
... and 2-fold (5,216 ± 2,140 ng/ml), respectively (Supplemental Figure 3, A and B), consistent with continuous secretion of 12-HETE by platelets and a dynamic release of AA by all blood cell ...PGD 2 and PGI ...
17
Cat’s whiskers (Orthosiphon stamineus) tea modulates arthritis pathogenesis via the angiogenesis and inflammatory cascade
... Results: Treatment with EOS resulted in dose-dependent inhibition of paw edema in acute and chronic models of inflammation. It also inhibited significantly the production of TNF- α , IL-1 COX-1, and ...
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Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP 1 human macrophages: a possible mechanism for increased cardiovascular risk
... of COX-2 on platelets and the effect on overall platelet function are still matters of controversy ...only COX- 1, COX-2 can be readily induced under conditions of vascular ...
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Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis
... on COX-2 expression occurred through disruption of the HuR/COX-2 mRNA association, ribonucleoprotein immunoprecipitation (RNP-IP) was performed in HCA-7 cells treated with 10 μM MS-444 for 6 ...
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Cyclooxygenase 1 and 2 expression in rheumatoid synovial tissues Effects of interleukin 1 beta, phorbol ester, and corticosteroids
... both Cox-1 and -2 under basal conditions in freshly explanted rheumatoid synovial ...of Cox-2 polypeptide was enhanced by IL-1 beta or PMA, and dramatically suppressed by ...
8
New functions for Cox 2 in health and disease: Report of “The Third International Workshop on Cox 2”, Ka’upulehu, Kona, Hawaii, USA, 30 August to 2 September 1999
... the Cox enzymes. He showed that substitution of Arg120 with glutamine in Cox-1 reduced its potency by a factor of 1000, whereas the same substitution in Cox-2 did not affect enzyme ...
5
Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase 1
... a 1:2000 dilution of affinity-purified goat anti–BrdUrd (26) at 4 8 C overnight following blocking of nonspecific protein binding sites with PBS containing 2% bovine serum albumin, ...mouse ...
14
Use of Propolis in Cancer Research
... Propolis has been reported to produce anti- inflammatory activity both in vitro and in vivo by the inhibition of proinflammatory cytokines and increase of anti-inflammatory cytokines 109,110. It may inhibit the ...
22
Cyclooxygenase 2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
... of COX-1 and COX-2 isoforms, and the target cells and tissues involved in adult bone repair, have not been clearly ...of COX-1 and COX-2 in bone healing is of para- ...
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New and novel uses for paracetamol
... Time-profile to the effect of 300mg/kg paracetamol on the basal body temperature in COX-1 & COX-2 genes knock-out mice.. COX-1 gene knockout mice.[r] ...
36
Cyclooxygenase selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read outs
... of COX- isozyme-selective and cell-specific inhibition, by virtue of its short half-life and its ability to inactivate COX irreversibly ...platelet COX-1 inhibition as is obtained with ...
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