Coxsackievirus A16
Potent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16
... Hand, foot and mouth disease (HFMD) usually manifests as a mild self-limiting childhood infection, causing sores on the hands, feet, mouth and buttocks, but can be associated with more serious symptoms, including fatal ...
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Combining Multiplex Reverse Transcription PCR and a Diagnostic Microarray To Detect and Differentiate Enterovirus 71 and Coxsackievirus A16
... Cluster A enteroviruses, including enterovirus 71 (EV71) and coxsackievirus A16 (CA16), are known to cause hand-foot-and-mouth disease (HFMD). Despite the close genetic relationship between these two ...
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Applicability of duplex real time and lateral flow strip reverse transcription recombinase aided amplification assays for the detection of Enterovirus 71 and Coxsackievirus A16
... Hand, foot and mouth disease (HFMD) is a common acute infectious disease with typical rash distribution characteristics in the mouth, hands and feet, and occurs mainly in the children under 5 years of age. Enterovi- ...
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Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large scale outbreaks from 2008
... RESEARCH Open Access Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large scale outbreaks from 2008 Zh[.] ...
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Genetic Characteristics of Human Enterovirus 71 and Coxsackievirus A16 Circulating from 1999 to 2004 in Shenzhen, People's Republic of China
... and coxsackievirus A16 (CA16) sampled from children with hand, foot, and mouth disease in Shenzhen, People’s Republic of China, over a 6-year period (1999 to 2004) were examined with reverse ...
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Phylogeography of Coxsackievirus A16 Reveals Global Transmission Pathways and Recent Emergence and Spread of a Recombinant Genogroup
... ABSTRACT Coxsackievirus A16 (CV-A16; Picornaviridae) is an enterovirus (EV) type associated with hand, foot, and mouth disease (HFMD) in children. To investigate the spatial spread of CV-A16, ...
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External Quality Assessment for Enterovirus 71 and Coxsackievirus A16 Detection by Reverse Transcription PCR Using Armored RNA as a Virus Surrogate
... Hand, foot, and mouth disease (HFMD) is an infectious disease commonly diagnosed in young children and character- ized by mucocutaneous papulovesicular rashes on the hands, feet, mouth, and buttocks. Human enterovirus 71 ...
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RSAD2 and AIM2 Modulate Coxsackievirus A16 and Enterovirus A71 Replication in Neuronal Cells in Different Ways That May Be Associated with Their 5′ Nontranslated Regions
... ABSTRACT Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) are closely related enteroviruses that cause the same hand, foot, and mouth disease (HFMD), but neurological complications occur only ...
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A Neonatal Mouse Model of Coxsackievirus A16 for Vaccine Evaluation
... A Neonatal Mouse Model of Coxsackievirus A16 for Vaccine Evaluation Qunying Mao,a Yiping Wang,a Rong Gao,b Jie Shao,a Xin Yao,a Shuhui Lang,a Chao Wang,c Panyong Mao,b Zhenglun Liang,a a[r] ...
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Comparative genetic analysis of VP4, VP1 and 3D gene regions of Enterovirus 71 and coxsackievirus A16 circulating in Malaysia between 1997 2008
... Abstract. Three genomic regions, VP4 capsid, VP1 capsid and 3D RNA polymerase of human enterovirus 71 (EV-71) and coxsackievirus A16 (CV-A16) were sequenced to understand the evolution of these ...
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Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity
... and coxsackievirus A16 (CVA16) are the primary causes of the epidemics of hand-foot-and-mouth disease (HFMD) that affect more than a million children in China each year and lead to hundreds of ...
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Evaluation of Reverse Transcription Loop Mediated Isothermal Amplification assays for Rapid Detection of Human Enterovirus 71 and Coxsackievirus A16 in Clinical Samples
... Human enteroviruses (HEVs) comprise more than 100 serotypes in four species (HEV-A to HEV-D) in the ge- nus Enterovirus, family Picornaviridae. Hand-Foot-and- Mouth Disease (HFMD) is a common febrile illness in young ...
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Construction and characterization of an infectious clone of coxsackievirus A16
... Coxsackievirus A16 (CVA16) and enterovirus 71 (EV71) are major etiological agents of hand, foot, and mouth disease (HFMD), which is a common illness in children ...
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Type I Interferons Triggered through the Toll-Like Receptor 3–TRIF Pathway Control Coxsackievirus A16 Infection in Young Mice
... Coxsackievirus A16 (CVA16) is one of the major etiological agents of hand, foot, and mouth disease (HFMD) in children. The host defense mechanisms against CVA16 infection remain almost entirely unknown. ...
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Beta-Propiolactone Inactivation of Coxsackievirus A16 Induces Structural Alteration and Surface Modification of Viral Capsids
... treated coxsackievirus A16 (CVA16) mature virions and procapsids, which reveals an expanded overall conformation and characteristic features that are typical for the 135S-like uncoating ...
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Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design
... Hand, foot, and mouth disease (HFMD) is a common viral illness among infants and young children, with clinical charac- terizations of prodromal fever followed by pharyngitis, mouth ulcers, and a rash on the hands and ...
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Cryo-Electron Microscopy Study of Insect Cell-Expressed Enterovirus 71 and Coxsackievirus A16 Virus-Like Particles Provides a Structural Basis for Vaccine Development
... and coxsackievirus A16 (CA16) are the two most common etiological agents responsible for the epidemics of hand, foot, and mouth disease (HFMD), a childhood illness with occasional severe neurological ...
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Improved Detection Limit in Rapid Detection of Human Enterovirus 71 and Coxsackievirus A16 by a Novel Reverse Transcription–Isothermal Multiple Self Matching Initiated Amplification Assay
... Rapid detection of human enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) is important in the early phase of hand-foot- and-mouth disease (HFMD). In this study, we developed and evaluated a novel ...
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Seroprevalence of antibodies to enterovirus 71 and coxsackievirus A16 among people of various age groups in a northeast province of Thailand
... Hand, foot and mouth disease (HFMD) is common in children below the age of 5. The disease is characterized by acute fever with vesicular rashes or blisters on the palms, soles, and oral mucosa. HFMD can be caused by any ...
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Characterization of VP1 sequence of Coxsackievirus A16 isolates by Bayesian evolutionary method
... Bayesian derivation and the maximum likelihood method have similar characteristics in that both have ex- cellent statistical characteristics. However, one difference is that the Bayesian method can use posterior ...
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