CpG oligodeoxynucleotides (ODN)
Antibody-mediated systemic delivery of CpG oligodeoxynucleotides for solid tumor immunotherapy
... immunotherapeutic CpG oligodeoxynucleotides in a DNP-immunized, syngeneic tumor-bearing mouse model ensued (Chapter ...DNP- CpG-ODNs warranted further pharmacodynamic studies (Chapter ...
114
Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system
... (CpG) oligodeoxynucleotides (ODNs) are recognized by Toll-like receptor 9 (TLR9) found in antigen-presenting cells and B cells and can activate the immune ...Using CpG ODNs as an adjuvant has been ...
15
Chitosan-coated boron nitride nanospheres enhance delivery of CpG oligodeoxynucleotides and induction of cytokines
... (CpG) oligodeoxynucleotides activate Toll-like receptor 9, leading to induction of proinflammatory cytokines, which play an important role in induction and maintenance of innate and adaptive immune ...
11
CpG Oligodeoxynucleotides with Hepatitis B Surface Antigen (HBsAg) for Vaccination in HBsAg-Transgenic Mice
... unmethylated CpG dinucleotides within the context of certain flanking sequences enhance both innate and antigen-specific immune responses, due in part to the enhanced production of Th1-type ...of ...
10
Antibody carriers of CpG oligodeoxynucleotides for solid tumor immunotherapy
... H]- CpG nor the maximum serum level could not be concretely established since we do not have data at the 1 hour time ...mediate ODN half-life in the circulation. 4 Analysis of the DNP-[ 3 H]-CpG data ...
115
CpG oligodeoxynucleotides enhance chemosensitivity of 5-fluorouracil in HepG2 human hepatoma cells via downregulation of the antiapoptotic factors survivin and livin
... of CpG- ODN in combination with ...that CpG-ODN in combination with 5-FU induced apoptosis by interrupting the transition of cell cycle from S phase into G2/M phase, suggesting that the ...
10
<p><em>N</em>-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264.7 Cell Osteoclastogenesis</p>
... ed ODN against enzymatic degradation. 31–33 However, modi fi ed CpG ODN can reduce the immune response and cause enlarge- ment of the immune ...of CpG ODN, including graphene oxide- ...
9
Immunomodulatory Effects of CpG Oligodeoxynucleotides on Established Th2 Responses
... of CpG ODN-induced inhibition of IL-5. Here, we demonstrated that CpG ODNs induced IL-10 from antigen- and alum-immunized splenocytes in a concen- tration-dependent ...by CpG ODNs showed a ...
10
CpG Oligodeoxynucleotides Facilitate Delivery of Whole Inactivated H9N2 Influenza Virus via Transepithelial Dendrites of Dendritic Cells in Nasal Mucosa
... Unmethylated CpG motifs are present at a much higher frequency in the genomes of prokaryotes than in those of eu- karyotes and present danger signals referred to as pathogen-asso- ciated molecular patterns (PAMPs) ...
15
The enhanced antitumor-specific immune response with mannose- and CpG-ODN-coated liposomes delivering TRP2 peptide
... 23]. CpG oligodeoxynucleotides (CpG-ODNs), short synthetic oligodeoxynucleotides containing optimized unmethylated CpG motifs, have progressed into clinical vaccine trials as adjuvants ...
17
A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN–based vaginal microbicide
... of CpG oligodeoxynucleotides (ODNs) and poly I:C has been shown to protect mice from genital herpes infection, the mechanism by which these agents provide protection remains ...for CpG ODN– ...
8
CpG DNA modulates interleukin 1β-induced interleukin-8 expression in human bronchial epithelial (16HBE14o-) cells
... by CpG-induced activation of ...[10]. CpG activation in human primary B cells and mac- rophages has been shown to be due to internalization of the DNA ...in CpG- induced ...
9
Flagellin A Toll-Like Receptor 5 Agonist as an Adjuvant in Chicken Vaccines
... Traditionally used adjuvants are inorganic compounds, bacte- rial products, and complex mixtures of surface-active com- pounds, mineral oil, and synthetic polymers (5, 6). Adjuvants based on alum and mineral oil are the ...
10
<p>Combination of CpG Oligodeoxynucleotide and Anti-4-1BB Antibody in the Treatment of Multiple Hepatocellular Carcinoma in Mice</p>
... a CpG group, a 4-1BB group and a CpG+4-1BB group, and drugs were injected into the tumor in the left lower extremity on the 7th, 9th, and 11th days after tumor ...The CpG group was administered ...
9
Cell traversal protein for ookinetes and sporozoites (CelTOS) formulated with potent TLR adjuvants induces high affinity antibodies that inhibit Plasmodium falciparum infection in Anopheles stephensi
... Lymphocyte proliferation and cytokine production in the cultured splenocyte cells of all the vaccine groups (1–5) were determined in vitro. On day 38 of the first immunization, 4 mice from each vaccine group were ...
16
Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-β knock-out mice
... before, CpG in mice results in production of several cytokines including type I IFN (IFN-α/ β)[37,38,54-56] which have the ability to exert indirect activation of T cells ...of CpG-ODN may be medi- ...
12
Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice
... with CpG as motif (CpG ODN). CpG ODN is synthetic DNA sequence containing unmethylated cytosine–guanine motifs that can imitate the bacteria or virus on stimulat- ing the vertebrate ...
6
Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo
... of CpG ODN induced a significant decrease in the percentage of viable cells which was not restored with the addition of BMSC and CD40L (mean % of viable cells in suspension ...with CpG ODN: ...
12
Semaphorin 3A is a marker for disease activity and a potential immunoregulator in systemic lupus erythematosus
... IL-10 and IL-6 cytokines in SLE was previously shown by many [29-31]. The over-expression of TLR-9 in memory B cells was also shown to be in correlation with anti-dsDNA antibody production. Thus, modula- tion of TLR-9 ...
8
Development of TLR9 agonists for cancer therapy
... Activation of innate and adaptive immunity by TLR9 activation. Among human immune cells, only B cells and pDCs constitutively express TLR9. These cells endocytose DNA into an endosomal compartment where it binds to TLR9, ...
12