Cranial Irradiation
Perihippocampal metastasis following hippocampus-avoiding prophylactic cranial irradiation for small cell lung cancer: a case report
... 3. Gondi V, Paulus R, Bruner DW, et al. Decline in tested and self-reported cognitive functioning after prophylactic cranial irradiation for lung cancer: pooled secondary analysis of Radiation Therapy ...
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Diffusion Tensor Imaging Screening of Radiation Induced Changes in the White Matter after Prophylactic Cranial Irradiation of Patients with Small Cell Lung Cancer: First Results of a Prospective Study
... new MR imaging sequences, like diffusion tensor imaging (DTI), allow an in vivo examination of the microstructure of the brain tissue. 8 Khong et al 9,10 studied the long-term effects of high-dose cranial ...
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Prophylactic cranial irradiation in non-small cell lung cancer patients: who might be the candidates?
... 5. Cox JD, Scott CB, Byhardt RW, et al. Addition of chemotherapy to radiation therapy alters failure patterns by cell type within non-small cell carcinoma of lung (NSCCL): Analysis of Radiation Therapy Oncology Group ...
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Eze, Chukwuka (2019): Treatment response and prophylactic cranial irradiation are prognostic factors in a real-life limited-disease small-cell lung cancer patient cohort comprehensively staged with cranial magnetic resonance imaging. Dissertation, LMU München: Medizinische Fakultät
... Prophylactic cranial irradiation (PCI) was initially proposed for SCLC in 1973 due to the high incidence of BM in these patients and insufficient control with whole brain ...
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Original Article Risk factors associated with brain metastases in patients with limited-stage small-cell lung cancer after prophylactic cranial irradiation
... Prophylactic cranial irradiation (PCI) has been the standard of practice for patients with limited- stage small-cell lung cancer after concurrent chemoradiotherapy (CRT), however, high brain metastasis rate ...
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Prophylactic cranial irradiation in small-cell lung cancer: update on patient selection, efficacy and outcomes
... Abstract: Over 10% of small-cell lung cancer (SCLC) patients have brain metastases (BM) at initial diagnosis; more than 50% will develop BM within 2 years. BM are detected in up to 80% of all patients at autopsy. After ...
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Cranial irradiation induces transient microglia accumulation, followed by long-lasting inflammation and loss of microglia
... is necessary for microglia viability [54], it is tempting to speculate that IR induced microglial loss at least partly by inhibiting CSF1R signaling. The numbers of dying microglia in the DG at any given time point may ...
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Treatment of Four Patients with Erythrophagocytic Lymphohistiocytosis by a Combination of Epipodophyllotoxin, Steroids, Intrathecal Methotrexate, and Cranial Irradiation
... Remission of disease was finally achieved with administration of VP 16-213 (200 mg/rn2 given in eight injections within 1 month) and intrathecal methotrexate (6 mg given twice.. a week f[r] ...
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Long-course versus short-course palliative cranial irradiation in brain metastases: a comparative study
... Results: At 12 months post WBRT, the objective response rate i.e. complete and partial response (CR+PR) was 6.67% in arm A and 13.34% in arm B (p=0.96). Both WBRT regimens showed similar survival (p=0.65). On ...
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Prophylactic cranial irradiation in locally advanced non-small cell lung cancer: outcome of recursive partitioning analysis group 1 patients
... Thoracic irradiation was given through the anteroposterior-posteroanterior (AP-PA) por- tals with individualized multileaf collimator blocks for PTV1 up to 46 Gy, followed by off-spinal cord oblique portals up to ...
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Long-term effects of cranial irradiation and intrathecal chemotherapy in treatment of childhood leukemia: a MEG study of power spectrum and correlated cognitive dysfunction
... brain irradiation and the neuropsychological deficiencies currently present, these findings suggest that the irradiated brain might be aging faster and could be at risk for early-onset dementia ...
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Clinical value of carcinoembryonic antigen for predicting the incidence of brain metastases and survival in small cell lung cancer patients treated with prophylactic cranial irradiation
... Clinical value of carcinoembryonic antigen for predicting the incidence of brain metastases and survival in small cell lung cancer patients treated with prophylactic cranial irradiati[r] ...
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Clinical Reasoning: A 68-year-old man with a history of lung cancer presenting with right-sided weakness and aphasia
... include (1) remote history of cranial irradiation with- out evidence of recurrent neoplasm, (2) prolonged reversible focal neurologic deficits (e.g., hemiparesis, aphasia, seizures), and (3) transient ...
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Growth Failure After Treatment of Pediatric Brain Tumors
... received cranial irradiation, were prepubertal or Tanner stage II at 2 years from completion of ...received cranial irradiation were compared with data from a group of 8 children diagnosed ...
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Reduced hypothalamic blood flow after radiation treatment of nasopharyngeal cancer: SPECT studies in 34 patients
... To determine the effect of cranial irradiation on hypothalamic blood flow, we performed 44 regional cerebral blood flow studies with 99 mTc hexamethyl propyleneamine oxime HMPAO single-p[r] ...
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Diffusion Tensor Imaging for the Detection and Quantification of Treatment Induced White Matter Injury in Children with Medulloblastoma: A Pilot Study
... surgery, cranial irradiation, and chemotherapy by use of diffusion-tensor (DT) imaging and compared FA findings in selected WM sites (cerebellar hemispheres, pons, medulla oblongata, frontal periventricular ...
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Radiation combined with temozolomide contraindicated for young adults diagnosed with anaplastic glioma
... The prognosis of grade II - IV malignant glioma is largely dependent on age. Recent studies have mainly focused on older patients and suggest that the benefit of treatment is reduced with age. [8] Cranial ...
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Risk factors of brain metastasis during the course of EGFR- TKIs therapy for patients with EGFR-mutated advanced lung adenocarcinoma
... prophylactic cranial irradiation (PCI) in NSCLC in terms of survival benefit prompted us to explore the possible risk factors for brain metastasis (BM) during the course of EGFR-TKIs therapy from ...
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NINE YEARS' EXPERIENCE WITH "TOTAL THERAPY" OF CHILDHOOD ACUTE LYMPHOCYTIC LEUKEMIA
... cranial irradiation, 2,400 rads, combined with intrathecal methotrexate, inhibits cen- tral nervous system relapse and results in considerable improvement in duration of complete remissi[r] ...
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Hemorrhagic vasculopathy after treatment of central nervous system neoplasia in childhood: diagnosis and follow up
... after cranial irradiation or radiation combined with systemic or intrathecal ...received cranial irradiation alone (n 5 9) or combined radiation and chemotherapy (n 5 11) for primary brain ...
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