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critical role

A Critical Role of Glutamine and Asparagine γ Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus

A Critical Role of Glutamine and Asparagine γ Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus

... We have previously shown that the oncogenic virus KSHV suppresses aerobic glycolysis (24). This reprogrammed metabolic program promotes the survival and cellular transformation of KSHV-infected cells, particularly under ...

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The critical role of uncertainty in  projections of hydrological extremes

The critical role of uncertainty in projections of hydrological extremes

... the critical role of uncertainty in the projection of future hydrological extremes in the Biala Tarnowska mountainous catchment in Poland in the 21st cen- ...

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The critical role of iron in host bacterial interactions

The critical role of iron in host bacterial interactions

... Reduction of the relatively high serum iron saturation of chick embryos by administration of the iron-binding protein conalbumin or pretreatment with endotoxin inhibits the growth and vi[r] ...

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A Critical Role for Dna2 at Unwound Telomeres

A Critical Role for Dna2 at Unwound Telomeres

... In budding yeast, checkpoint mutations such as rad9 D and ddc1 D exacerbate fitness defects caused by general DNA rep- lication defects (e.g., defects in DNA ligase, Pol a , Pol e, or Pol d ) (Weinert et al. 1994; Dubarry ...

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A critical role for myoglobin in zebrafish development

A critical role for myoglobin in zebrafish development

... important role in oxygen storage and ...the role of myoglobins in development by targeted gene ...crucial role in zebrafish development and is important for angiogenesis and gut ...

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Critical role of galectin 3 in phagocytosis by macrophages

Critical role of galectin 3 in phagocytosis by macrophages

... In summary, galectin-3 plays an important role in the overall function of macrophages. Previous work has shown that this lectin is highly upregulated as monocytes differentiate into macrophages. Other studies have ...

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The critical role of relationship in education

The critical role of relationship in education

... http //www hts org za doi 10 4102/hts v71i3 2702 Page 1 of 8 Original Research Author Francois Wessels1,2 Affiliations 1Life Coach and Narrative Practitioner, Coaches and mentors of South Africa (COME[.] ...

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The Critical Role of Provider Practices in Undervaccination

The Critical Role of Provider Practices in Undervaccination

... variety of practices to improve the quality of immu- nization practices, including removing barriers to vaccination, screening of all patients for vaccination status at every visit, simu[r] ...

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A critical role for the NFkB pathway in multiple myeloma

A critical role for the NFkB pathway in multiple myeloma

... 20]. There are two general pathways of activation – clas- sical (or canonical) and alternative (Figure 1). Many dif- ferent stimuli, including external signaling through B cell receptors (BCR) and some tumor necrosis ...

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A Critical Role for the Putative NCS2 Nucleobase Permease YjcD in the Sensitivity of Escherichia coli to Cytotoxic and Mutagenic Purine Analogs

A Critical Role for the Putative NCS2 Nucleobase Permease YjcD in the Sensitivity of Escherichia coli to Cytotoxic and Mutagenic Purine Analogs

... the role of YicO may be taken to suggest that this gene has a limited involvement in HAP uptake, an alternative explanation, which we favor, is that the reduced HAP sensitivity of the ⌬yicO::kan strain that we ...

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Critical role of zinc in hardening of Nereis jaws

Critical role of zinc in hardening of Nereis jaws

... There are significant data suggesting at least an indirect role of metals in the hardening of invertebrate mandibles (Edwards et al., 1993; Hillerton et al., 1984; Hillerton and Vincent, 1982; Lichtenegger et al., ...

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Strengthening Lives, Shifting Behaviour

Strengthening Lives, Shifting Behaviour

... a critical role in organising and capacitating a critical mass of folk artists who can provide language and dialect-specific customised social and behaviour change messages across the state through ...

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Quality In E-Procurement Success

Quality In E-Procurement Success

... a critical role to achieve customer satisfaction (Mentzer et ...is critical, since it plays a key role in reaching the coordination of all parties ...

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TUBERIN REGULATION IN NEURAL TISSUE AND CELL FATE

TUBERIN REGULATION IN NEURAL TISSUE AND CELL FATE

... a critical role in the maintenance of the stem cell population; whether it is through self-renewal, survival or proliferation remains to be further ...Tuberin role in stem-cell self-renewal is either ...

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Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies

Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies

... a critical role in the inhibition of NR2B-containing NMDA recep- tors (IC 50 (mutant)/IC 50 (WT) > 60) are highlighted in ...three critical residues to be located within the puta- tive central ...

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Critical competencies required for the role of the modern CIO

Critical competencies required for the role of the modern CIO

... the role of the modern ...described critical competencies required for the role of the ...the critical competencies was rated on a Likert scale from 0 to 4, with 0 being not relevant, 1 being ...

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Ideological Traces in Political Texts: A CDA Approach towards News Representation and Translation of Iran’s Nuclear Program in English and Persian Written Media

Ideological Traces in Political Texts: A CDA Approach towards News Representation and Translation of Iran’s Nuclear Program in English and Persian Written Media

... The study showed that the underlying reasons behind ideological manipulation of the news texts are twofold. Firstly, news accounts are far from being "pure" and "impartial" reflections of ...

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Mathematics in Advancements of Science and Technology "Boon for Society"

Mathematics in Advancements of Science and Technology "Boon for Society"

... animal and human life depends upon the co-operation of each other. Group work helps social skills. The ability to work together on tasks with others can build various social skills. In order to live a social life, ...

5

Designer as subject: role play as a teaching strategy in undergraduate design education

Designer as subject: role play as a teaching strategy in undergraduate design education

... Role play clearly has both instrumental and critical dimensions, and these parallel aspects are a crucial feature in the use of role playas a teaching strategy in de[r] ...

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An investigation of the function of I[kappa]B family member Bcl-3 and its role in oncogenesis

An investigation of the function of I[kappa]B family member Bcl-3 and its role in oncogenesis

... The ability of Bcl-3 to activate transcription of genes such as the anti-apoptotic Bcl-2 and cell cycle activator cyclin D1 has been suggested to contribute to its oncogenicity, but direct links from these activities to ...

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