Crohn Disease
Proteasome mediated degradation of IκBα and processing of p105 in Crohn disease and ulcerative colitis
... Enhanced NF-κB activity is involved in the pathology of both forms of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC). Here we analyzed the mechanism of ...
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Original Article Correlation between TLR4 genetic polymorphisms and susceptibility to neonatal early Crohn disease
... early Crohn disease in ...early Crohn disease and 100 healthy controls through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) ...early Crohn dis- ...early ...
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Magnetization Transfer Helps Detect Intestinal Fibrosis in an Animal Model of Crohn Disease
... Histologically, Crohn strictures typically contain a mix- ture of infl ammatory and mesenchymal cells along with extracellular matrix com- ponents with varying degrees of fi ...
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Bacterial flagellin is a dominant antigen in Crohn disease
... bowel disease (IBD), results from an aberrant and poorly understood mucosal immune response to the microbiota of the gastrointestinal tract in genetically susceptible ...with Crohn disease, but not ...
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Adherent invasive E coli in Crohn disease: bacterial “agent provocateur”
... The role of adherent-invasive E. coli (AIEC) in Crohn disease (CD) has been in debate for decades. AIEC bacteria are found in the small intestine of patients with chronic CD, but it has remained unclear ...
5
CT enterography of pediatric Crohn disease
... CTE almost always utilizes intravascular iodinated low- osmolality (or iso-osmolality) contrast material unless specifically contraindicated. We administer an intravenous dose of 2 ml/kg (maximum dose, 125 ml) using a ...
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Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature
... behavior, often dictating different medical and surgical ap- proaches, further implying the need for additional classification approaches. More importantly, disease classification should take into account ...
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A morphometric study on intestinal mucosal biopsies in inflammatory bowel disorders.
... and Crohn‟s disease ...bowel disease of uncertain ...proximally. Crohn disease is a chronic, multifocal, relapsing, remitting inflammatory disease that can afflict any part of ...
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The effect of immunomodulators on the immunogenicity of TNF blocking therapeutic monoclonal antibodies: a review
... revolutionized the treatment of various infl ammatory diseases. Immunogenicity against these antibodies has been shown to be clinically important: it is associated with shorter response duration because of diminishing ...
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Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease
... in Crohn disease (CD) and ulcerative colitis (UC), the 2 major forms of inflammatory bowel disease (IBD), there was loss of expression of endothelial EPCR and TM, which in turns caused impairment of ...
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The fundamental basis of inflammatory bowel disease
... Two broad hypotheses have arisen regarding the fundamental nature of the pathogenesis of inflammatory bowel diseases (IBDs, which include ulcerative colitis and Crohn disease). The first contends that ...
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Contextual Radiology Reporting: A New Approach to Neuroradiology Structured Templates
... establish disease dissemination in space are characterized as having at least 2 of the 5 findings: ⱖ 3 periventricular lesions, ⱖ 1 infratentorial lesion, ⱖ 1 spinal cord lesion, ⱖ 1 optic nerve lesion, and ⱖ 1 ...
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Co inheritance of variants/mutations in Malaysian patients with Crohn s disease
... Crohn’s disease (CD) is a major form of chronic inflammatory bowel disease, apart from ulcerative colitis (Sugimura et al., 2003). CD usually causes swelling in the intestines, and can affect any part of ...
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Leistner, Dorothea (2011): Die Rolle des CXCL16 p.Ala181Val-Polymorphismus bei chronisch entzündlichen Darmerkrankungen. Dissertation, LMU München: Medizinische Fakultät
... M. Crohn-Phänotypen bei mehreren NOD2/CARD15- Varianten ...M. Crohn-Patienten auf das Vorhandensein der drei M. Crohn assoziierten NOD2/CARD15-Varianten ...M. Crohn-Patienten (siehe Tabelle ...
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Matrix metalloproteinases in inflammatory bowel disease: an update
... TNF-𝛼 is a proinflammatory cytokine whose levels are increased in the blood, colonic mucosa, and stools of IBD patients. It contributes to the pathogenesis of the disease by increasing inflammation through MAPK ...
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Burden of Crohn’s disease: economics and quality of life aspects in Italy
... Quality of life as measured by the EQ-5D was 0.558 ini- tially, increasing to 0.739, with a mean value of 0.677 during the study. Drug treatment was the most important cost item (60%), followed by the cost of ...
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New biologics in the management of Crohn’s disease: focus on certolizumab pegol
... In vitro studies have demonstrated that infliximab, certolizumab, adalimumab, and etanercept are all able to neutralize soluble TNF- α and membrane-bound TNF- α . Infliximab and adalimumab are comparable in their ability ...
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Is there a role for vedolizumab in the treatment of ulcerative colitis and Crohn’s disease?
... In the future, vedolizumab and other disease-modifying drugs may have a place in first-line therapy in those patients with IBD. Current medical management of IBD is based on a step-wise system with treatments ...
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Maintenance treatment with infliximab for the management of Crohn’s disease in adults
... bowel disease, having been demonstrated to be effi cacious in inducing a rapid clinical response, both in CD and ulcerative colitis; however, apart from their inability to maintain a long-lasting remission, the ...
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Measuring disease activity in Crohn's disease: what is currently available to the clinician
... considers both the extent and the severity of small bowel damage (bowel wall thickness, lumen diameter, length of lesions, and number of sites involved), as well as fistulas, mesenteric adipose tissue changes, abscesses, ...
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