CSF-1
Colony stimulating factor 1 (CSF 1) rescues osteoblast attachment, survival and sorting of beta actin mRNA in the toothless (tl osteopetrotic) mutation in the rat
... of CSF-1, a growth factor, increase bone resorption and growth in tl rats, we examined the effects of CSF-1 treatment on osteoblast survival and ultrastructure in vivo and ability to sort ...
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Pivotal Advance: Avian colony stimulating factor 1 (CSF 1), interleukin 34 (IL 34), and CSF 1 receptor genes and gene products
... of CSF-1/CSF1R suggest that dimerization permits interactions between the two D4 do- mains, leading to a conformational change that generates signaling ...a CSF-1-dependent growth-promoting ...
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The effect of CSF-1 administration on lung maturation in a mouse model of neonatal hyperoxia exposure
... Overall, CSF-1 treatment showed little effect in pro- moting alveolar formation in the hyperoxic settings employed in this ...that CSF-1-responsive macrophages are not effective can be ...
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CSF 1 signals directly to renal tubular epithelial cells to mediate repair in mice
... to CSF-1– dependent renal repair, we used CD11b-DTR mice with a diph- theria toxin–inducible (DT-inducible) system that transiently depletes macrophages ...days 1 and 3 after I/R, we evaluated macro- ...
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CSF 1 signaling mediates recovery from acute kidney injury
... that CSF-1–mediated expan- sion and polarization of resident renal macrophages/dendritic cells is an important mechanism mediating renal tubule epithelial regeneration after ...
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CSF-1 and Ang-2 serum levels — prognostic and diagnostic partners in non-small cell lung cancer
... of CSF-1 have a 17-fold increased likelihood of presenting ...High CSF-1 serum levels is associated with a 5-fold higher probability of NSCLC ...and CSF-1 (alone or in ...
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Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia
... to CSF-1 while surprisingly, microglia were not ...anti- CSF-1 effects on ...anti- CSF-1 treatment while microglia-induced invasion was reduced to a lower ...of ...
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Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development
... Epithelial/mesenchymal cell interactions are necessary for proper ductal morphogenesis throughout all stages of mammary gland development. Besides the well-established stromal components, such as adipocytes and ...
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Small molecule immunomodulation: the tumor microenvironment and overcoming immune escape
... [21]. CSF-1R is a receptor tyrosine recep- tor that is an important regulator of myeloid cell differen- tiation, proliferation, migration and survival, and FAK is a non-receptor tyrosine kinase that is a critical ...
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Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony stimulating factor 1, and recombinant murine granulocyte macrophage colony stimulating factor on myelopoiesis in mice
... natural CSF-1, and recombinant granulocyte-macrophage (GM) CSF were assessed in vivo for their effects on BDF1 mouse bone marrow and spleen granulocyte-macrophage (CFU-GM), erythroid (BFU-E), and ...
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Macrophage Growth Factors Introduced into the Kidney Initiate Renal Injury
... Using a retroviral gene transfer system, we transfected CSF-1 and another MO growth factor, GM-CSF, into renal tubular epi- thelial cells (TEC), and then placed these genet- ically modif[r] ...
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A Unified Management for Spontaneous CSF Leak
... However, not only is there a potential for associated complications, but there is also the need for hospitaliza- tion when these drains are used [26]. These are the same complications occurring when using a permanent ...
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Discordant amyloid-β PET and CSF biomarkers and its clinical consequences
... We included 768 patients who visited our tertiary mem- ory clinic between November 2005 and November 2017 and underwent both lumbar puncture and Aβ PET within 365 days. All patients underwent a standard diag- nostic ...
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Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40
... with CSF protein levels using age, gender, sample batch, and two princi- pal component factors for population stratification as ...Fig. 1 and Additional file 5: Table ...
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Pichia pastoris versus Saccharomyces cerevisiae: a case study on the recombinant production of human granulocyte macrophage colony stimulating factor
... Background: Recombinant human granulocyte‑macrophage colony‑stimulating factor (rhGM‑CSF) is a glycoprotein that has been approved by the FDA for the treatment of neutropenia and leukemia in combination with ...
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Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies
... Figure 1 Model of osteoclastogenesis during bone homeostasis and tumor cell metastasis to bone. A) In normal bone, RANKL and m-CSF are produced primarily by osteoblasts. m-CSF binds to its receptor ...
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Possible role of the cavernous sinus veins in cerebrospinal fluid absorption
... to CSF. However, for any dural CSF transport to occur, presumably CSF would have to pass through the supposed barrier provided by the arachnoid membrane to enter dural ...granulations). CSF ...
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M CSF neutralization and Egr 1 deficiency prevent ovariectomy induced bone loss
... and soluble M-CSF, although different mechanisms are involved. The expression of membrane-bound M-CSF on bone marrow cells is directly inhibited by E2 (13, 14), although it has not yet been determined ...
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Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer’s disease patients
... corresponding CSF samples were selected from the Alzheimer Center Memory Cohort, NeuroUnit Biomarkers for Inflammation and Neurodegeneration, VU Medical Center (VUmc) Biobank (Amsterdam, the ...short CSF ...
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Fast multiphase MR imaging of aqueductal CSF flow: 1 Study of healthy subjects
... The results of these investigations demonstrated that, whereas a substantial correlation between theoretical prediction of flow rate and experimental data can be found in the case of con[r] ...
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