CSF biomarkers
Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease
... of CSF A b 42/A b 40, A b 42/t-tau, and A b 42/p-tau, a compar- ison of 2 different ELISAs for CSF A b 42, and evalu- ation of the combination of PET and CSF ...for CSF biomarkers and ...
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CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau
... between CSF biomarkers may provide better pathogenic understanding by hinting to simultaneously ongoing processes in the ...brain. CSF A β and t-tau/p-tau markers related positively to CSF ...
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Longitudinal CSF biomarkers in patients with early Parkinson disease and healthy controls
... in CSF biomarkers and key clinical measures (MDS-UPDRS part III score and total score), each of which increased over 6 and 12 months in PD (tables 4 and ...in CSF biomarkers (table ...
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Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
... between CSF biomarkers in males and females were found in PD or HC groups ( p = 0 · ...the biomarkers was assessed based on the area under the curve (AUC) of the receiver operating characteristic ...
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CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment
... with incipient AD. However, the considerable intercenter variations in assays and patient assessments described point to a need for standardization of sample handling as well as of clinical assessments. Although each ...
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Discordant amyloid-β PET and CSF biomarkers and its clinical consequences
... and CSF biomarkers. First, the ma- jority of discordant cases are CSF+/ PET−, with the highest proportion of CSF+/PET− profiles observed in cognitively normal individuals [10–13, ...in ...
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CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia
... on CSF biomarkers and that we did not find any significant differences in biomarker values across homogenous groups examined by the two centers speak against a sig- nificant inter-laboratory variability ...
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Utility of CSF biomarkers in psychiatric disorders: a national multicentre prospective study
... AD CSF biomarkers are the only markers that reflect the AD neuropathological lesions associating tau and amyloid β [11, ...Positive CSF biomarkers imply that patients have AD brain lesions ...
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CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease
... between CSF biomarkers and cortical thickness in some but not all areas that were significant in the voxel- wise regression models (data available from Dryad) (table 5) ...the biomarkers and cortical ...
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Combining MR Imaging, Positron Emission Tomography, and CSF Biomarkers in the Diagnosis and Prognosis of Alzheimer Disease
... and CSF biomarkers were all sen- sitive to diagnostic ...and CSF measures (t-tau/A  ...the CSF biomarker in addition to MR imaging hip- pocampal volume did result in a significant improvement ...
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Increased CSF biomarkers of angiogenesis in Parkinson disease
... individuals with major somatic comorbidities or using of anti-inflammatory medications did not significantly differ across groups, thus these factors are unlikely to have confounded our findings. A strength of the pre- ...
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Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay
... cost-effective biomarkers that can help diagnose patients earlier and more ...(CSF) biomarkers in neurodegenera- tion has been shown by the development of β amyloid 1 – 42 (A β 42), total tau protein ...
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Cerebrospinal fluid (CSF) biomarkers of iron status are associated with CSF viral load, antiretroviral therapy, and demographic factors in HIV-infected adults
... HIV affects an estimated 40 million people worldwide [1], and owing to the success of combination antiret- roviral therapy (ART) in suppressing viral replication, this population is aging [2–4]. An increasing number of ...
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Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis
... with CSF-NFL and an ability to reflect disease activity in MS [15, 29, 30] was here confirmed, reiterating the sugges- tion of S-NFL as a promising ...[31]. CSF-NFL was however not re- ported, and in our ...
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Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease
... The CSF biomarkers tau and A b are today well validated markers for AD pathology and they are associated with development of AD dementia in individuals with mild cognitive impairment ...these CSF ...
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Effects of surgery and propofol-remifentanil total intravenous anesthesia on cerebrospinal fluid biomarkers of inflammation, Alzheimer’s disease, and neuronal injury in humans: a cohort study
... of biomarkers than other similar studies, but we still acknowledge that there may be other biomarkers that were not tested here and that may be important in AD, including for example IL-1 ...last CSF ...
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Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers
... changes are detectable using CSF and amyloid PET bio- markers [32–34]. Amyloid positivity is often recognized as the earliest detectable pathophysiological abnormality in AD. Typically, positivity has been ...
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No diurnal variation of classical and candidate biomarkers of Alzheimer’s disease in CSF
... (CSF) biomarkers have gained increasing importance in the diagnostic work-up of Alzheimer ’ s disease ...core CSF biomarkers related to AD pathology (A β 42, t-tau and p-tau) are currently ...
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Amyloid and tau cerebrospinal fluid biomarkers in HIV infection
... 5 biomarkers and their diagnostic utility in ADC diagnosis compared to all HIV+ subjects (neuroasymptomatic and opportunistic infections) and to the neuroasymptomatics alone (exclud- ing the opportunistic ...
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Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid
... normal CSF Aβ42 levels, all three CSF biomarkers Aβ42, t-tau, and p- tau were key predictors of progression to dementia/AD ...continuous CSF biomarkers may be prefer- able [50, ...
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