CTL, cytotoxic T cells
Cytotoxic T cells and viral hepatitis
... the CTL response during acute HBV infection suggests an impor- tant role for CTL in the pathogenesis of acute viral hepatitis, proof of this hypothesis required the development of trans- genic mice that ...
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Analysis of T cell responses in liver allograft recipients Evidence for deletion of donor specific cytotoxic T cells in the peripheral circulation
... recipient cells with semisyngeneic cells having both donor and third-party HLA antigens failed to reveal the presence of cytotoxic T cells (CTL) specific to the donor, whereas ...
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The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL.
... pp65-specific CTL from a number of donors was to determine whether donors who shared HLA class I alleles also had CTL specific to the same pp65 ...have CTL specific for the matrix protein M58-66 ...
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Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation
... for T-cells with a T-cell receptor of known antigen specificity), or by column selection of interferon-gamma- producing T-cells following a brief stimulation with an antigen of inter- ...
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Recognition of clonogenic leukemic cells, remission bone marrow and HLA identical donor bone marrow by CD8+ or CD4+ minor histocompatibility antigen specific cytotoxic T lymphocytes
... CD4+ CTL clone showed specific lysis of the leukemic-HPC from an AML patient and a CML patient as well as of normal remission-HPC and ...specific CTL clones do not differentially recognize leukemic-HPC and ...
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The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells
... dendritic cells (DCs) with respect to maturation and ability to activate human tumor antigen-specific cytotoxic T-cell (CTL) lines, and subsequent T-cell lysis of tumor cells, ...
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Fitness Costs and Diversity of the Cytotoxic T Lymphocyte (CTL) Response Determine the Rate of CTL Escape during Acute and Chronic Phases of HIV Infection
... different CTL re- sponses, a rise in novel CTL responses can lead to a decrease in the contribution of already existing CTL ...infected cells. In the model where only one CTL can bind ...
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Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection
... control animals infected i.r. in this study and as reported else- where) (1). Therefore, the use of two different challenge virus stocks (SIVmac239/nef-open and SIVmac239/nef-stop) should not have had any significant ...
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The reovirus nonstructural protein sigma1NS is recognized by murine cytotoxic T lymphocytes.
... 2 cells (American Type Culture Collection). CTL reactivity to reovirus s 1NS ...node-derived CTL cultures to specific re- ovirus proteins was analyzed using target cells infected with vaccinia ...
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Progress in research on paclitaxel and tumor immunotherapy
... cancer cells, the immunological aspects of ovarian cancer chemotherapy in pa- tients, and the cytotoxic T lymphocyte (CTL) response of tumor antigens to CD8(+) T cells in the ...
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Normal self proteins as targets for tumour specific cytotoxic T lymphocytes (CTL)
... by CTL do not induce immune ...induce CTL despite expressing high levels o f a defined tum our antigen, the human papillomavirus protein ...of CTL able to recognise both the B7-1 positive and B7-1 ...
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Enhanced presentation of MHC class Ia, Ib and class II restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy
... CD8aa+TCRab+ T cells that target autoaggressive Vb8.2+ T cell responses for down-regulation and protection against autoimmune disease ...CD8aa+TCRab+ T cell and MHC class II-restricted CD4+ ...
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CD40 Ligand-Mediated Interactions Are Involved in the Generation of Memory CD8+ Cytotoxic T Lymphocytes (CTL) but Are Not Required for the Maintenance of CTL Memory following Virus Infection
... that are essential for B-cell activation and differentiation, class switching, germinal center formation, and the generation of B-cell memory (reviewed in references 21 and 31). More re- cently, roles for CD40L-CD40 ...
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Dynamics of a fractional order HBV infection model with capsids and CTL immune response
... Abstract. In this article, a fractional order model for hepatitis B virus (HBV) infection with capsids and immune response presented by cytotoxic T lymphocyte (CTL) cells is proposed and ...
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Virotheranostics, a double-barreled viral gun pointed toward cancer; ready to shoot?
... ing cells; NK: Natural killer; MHC-I: Major histocompatibility complex class-I; CTL: Cytotoxic T-lymphocytes; PRRs: Pattern recognition receptors; SPECT: Sin- gle-photon emission computed ...
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The generation of cytotoxic T cell epitopes and their generation for cancer immunotherapy
... regulatory T cell responses, and, as elaborated in this thesis, (4) an ap- propriate multipotent target choice, will help to improve vaccine ...adoptive T cell transfer is an important im- munotherapeutic ...
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Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP 1 and loss of expression of the immunodominant MART 1/Melan A antigen
... PM1-B1 cells after gene gun delivery of the TAP-1 gene and selection for 10 d in G418 ...). T cell recognition of PM1-B1 cells after TAP-1 gene transfer was examined using the polyclonal TIL line ...
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Persistence of vesicular stomatitis virus in cloned interleukin-2-dependent natural killer cell lines.
... Cloned lines of H-2-restricted hapten- or virus-specific cytotoxic T lymphocytes CTL and alloantigen-specific CTL were resistant to productive infection by vesicular stomatitis virus VSV[r] ...
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MyD88 Expression Is Required for Efficient Cross-Presentation of Viral Antigens from Infected Cells
... In terms of cross-presentation of cell-associated antigens, an important issue that remains to be studied is the role of mRNA and viral RNA in the physiological process of cross-presenta- tion of cell-associated antigens ...
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Into the clinic: Talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy
... (T-VEC) T-VEC is a modified herpes simplex virus, type 1 (HSV-1) [1] that has undergone genetic modifications to promote selective tumor cell replication, while reducing viral pathogenicity and promoting ...
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