CTL, cytotoxic T lymphocytes
Normal self proteins as targets for tumour specific cytotoxic T lymphocytes (CTL)
... While the network of hydrogen bonds and van der Waal's contacts connects the peptide main chain to complementary MHC side chains, further interactions involve a few peptide binding side chains. These interactions impose ...
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Virotheranostics, a double-barreled viral gun pointed toward cancer; ready to shoot?
... class-I; CTL: Cytotoxic T-lymphocytes; PRRs: Pattern recognition receptors; SPECT: Sin- gle-photon emission computed tomography; OMV: Oncolytic measles virus; NIS: Sodium iodide Symporter; ...
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CD40 Ligand-Mediated Interactions Are Involved in the Generation of Memory CD8+ Cytotoxic T Lymphocytes (CTL) but Are Not Required for the Maintenance of CTL Memory following Virus Infection
... effector CTL activity mediated by each test population was also ...tor CTL activity exhibited by CD40L-deficient and control mice was indistinguishable ...direct CTL lysis were not as high and the ...
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Kinetics of Antiviral Activity by Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes (CTL) and Rapid Selection of CTL Escape Virus In Vitro
... specific CTL-mediated cytolysis, first observed well before peak virus production, indicate that CTL may prevent a sig- nificant quantity of virus from being ...Env-specific CTL- mediated lysis of ...
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The combination of dendritic cells-cytotoxic T lymphocytes/cytokine-induced killer (DC-CTL/CIK) therapy exerts immune and clinical responses in patients with malignant tumors
... numerates lymphocytes both in tumor center (CT) and invasive margin (IM), has been intro- duced to add to the significance of the American Joint Committee on Cancer (AJCC)-Union for International Cancer Control ...
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Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection
... CM9-specific CTL responses detected during the acute phase of infection in SIVmac239-infected macaques ...CM9-specific CTL were not boosted (both animals showed an increase to only ...CM9-specific ...
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Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTL precursors after rotavirus infection.
... 65, 1991 tinal and nonintestinal lymphocytes after rotavirus infection, adult mice were inoculated orally or via the hind footpad with RRV; virus-specific cytotoxic activities in intesti[r] ...
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Recognition of clonogenic leukemic cells, remission bone marrow and HLA identical donor bone marrow by CD8+ or CD4+ minor histocompatibility antigen specific cytotoxic T lymphocytes
... antigen-specific cytotoxic T lymphocytes (CTL) can discriminate between leukemic hematopoietic progenitor cells (leukemic-HPC) from AML or CML patients, the HPC from their remission bone ...
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Dengue virus protein recognition by virus-specific murine CD8+ cytotoxic T lymphocytes.
... We studied the recognition by murine dengue virus-specific major histocompatibility complex class I-restricted, CD8+ cytotoxic T lymphocytes CTL of dengue virus proteins using recombinan[r] ...
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Cytotoxic T lymphocytes form an antigen independent ring junction
... We thank A. Diefenbach and A. Shaw for discussions on NKG2D. We thank N. Desai and R. Houdei for prepa- ration of the ICAM-1–GPI liposomes. We thank R. Rothlein (Boehringer Ingelheim, Ridgefield, Connecti- cut, USA), ...
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Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.
... specific CTL are thought to inhibit virus replication by lysing infected cells before infectious virions can be ...of CTL for the experiments depicted in ...the CTL clones were able to recognize ...
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Persistence of vesicular stomatitis virus in cloned interleukin-2-dependent natural killer cell lines.
... Cloned lines of H-2-restricted hapten- or virus-specific cytotoxic T lymphocytes CTL and alloantigen-specific CTL were resistant to productive infection by vesicular stomatitis virus VSV[r] ...
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Enhanced presentation of MHC class Ia, Ib and class II restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy
... Methods: To address this issue, we have engineered polylactic-co-glycolic acid (PLGA) nanoparticles incorporating: (i) two MHC class I-restricted clinically-relevant peptides, (ii) a MHC class II-binding peptide, and ...
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The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL.
... Cytotoxic T lymphocytes (CTL) appear to play an important role in the control of human cytomegalovirus (HCMV) in the normal virus carrier: previous studies have identified peripheral blood CD8 ...
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Targeting the inflammation in HCV associated hepatocellular carcinoma: a role in the prevention and treatment
... hepatic T cells are either CD4+ or double negative (CD4-CD8-) and express receptors typi- cal of both NK cells (CD16+, CD56+, CD161+) and T- cells (T-cells receptors, ...conserved T-cell ...
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Chemo-immunotherapy improves long-term survival in a preclinical model of MMR-D-related cancer
... + cytotoxic T cells gradually ...again, T cell numbers (both Th and CTL) increased after chemo-immunotherapy, while im- mune regulatory cells were found to be ...
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Into the clinic: Talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy
... [18]. T-VEC is prepared in a sterile biosafety cabinet by thawing frozen vials, stored at −70 °C or colder, at room temperature until conversion to liquid ...with T-VEC, universal precautions should be ...
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Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes
... memory T cells, respectively; while the IL-15–treated cells were capable of migration into peripheral lymph nodes, the IL-2–treated cells were selectively excluded from lymph nodes, but homed pref- erentially to ...
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Virus-Specific CD4+ T Cells Eliminate Borna Disease Virus from the Brain via Induction of Cytotoxic CD8+T Cells
... points, T-cell-treated rats had clinical scores that were transiently very low or exhibited no clinical symptoms (Tables 2 and ...in T-cell-treated rats, a low-level encephalitic reaction was again seen by ...
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Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans.
... After infection with vaccinia virus, the 10% infected, gamma-irradiated autologous PBMC and the 90% uninfected, gamma-irradiated autologous feeder PBMC were combined and resuspended to 1[r] ...
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