CTL responses
IL 12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro
... Dendritic cells induce potent human antiviral CD81 CTL responses without the requirement for CD41 T cells or exoge- nous cytokines (13). We hypothesized, therefore, that den- dritic cells produce IL-12 when ...
9
Identification of Dominant Optimal HLA-B60- and HLA-B61-Restricted Cytotoxic T-Lymphocyte (CTL) Epitopes: Rapid Characterization of CTL Responses by Enzyme-Linked Immunospot Assay
... detectable CTL response directed against some of these regions of HIV-1 ...immune responses could not be addressed from this study, but previous studies of the kinetics of HIV-1-specific CTL re- ...
9
Human Memory Cytotoxic T-Lymphocyte (CTL) Responses to Hantaan Virus Infection: Identification of Virus-Specific and Cross-Reactive CD8+ CTL Epitopes on Nucleocapsid Protein
... T-cell responses. Similarly, the Sin Nombre virus-specific CTL lines established in our labo- ratory included both Sin Nombre virus-specific and cross-re- active lines ...T-cell responses are dengue ...
8
Cellular immune responses against the tumour associated polymorphic epithelial mucin MUC1
... The ability of the cellular arm of the immune system to specifically recognise and eliminate cells harbouring foreign invaders such as viruses and parasites has been studied in great detail. This body of work has led to ...
201
Priming of Cytotoxic T Lymphocytes by DNA Vaccines: Requirement for Professional Antigen Presenting Cells and Evidence for Antigen Transfer from Myocytes
... that induction of CTL responses following DNA immunization is restricted by the haplotype of the donor BM cells, indicating that BM-derived professional APCs are responsible for direct i[r] ...
10
Kaposi's Sarcoma-Associated Herpesvirus Cytotoxic T Lymphocytes Recognize and Target Darwinian Positively Selected Autologous K1 Epitopes
... predict CTL responses ...for CTL responses against K1 and whether this is a result of a viral immune evasion mechanism towards common HLA class I ...
9
Detection of Diverse Hepatitis C Virus (HCV)-Specific Cytotoxic T Lymphocytes in Peripheral Blood of Infected Persons by Screening for Responses to All Translated Proteins of HCV
... the CTL response using meth- ods that require in vitro stimulation is potentially problematic since the measurements reflect the antigen-specific cells that have survived the incubation period rather than the ...
7
“Stealth” Adenoviruses Blunt Cell-Mediated and Humoral Immune Responses against the Virus and Allow for Significant Gene Expression upon Readministration in the Lung
... This “antigen switching” pattern is further supported by our results with animals that received two consecutive doses of vector conjugated by the same activated polymer. In this case, readministration of the same vector ...
10
Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes.
... 1 CTL responses. CTL memory does not prevent viral reinfection per se, because virus-specific CTL responses must first be stimulated by presentation of CTL peptides on virally ...
9
Human histocompatibility leukocyte antigen binding supermotifs predict broadly cross reactive cytotoxic T lymphocyte responses in patients with acute hepatitis
... recall CTL responses from PBL of patients with ongoing acute viral hepatitis or previous HBV ...tive CTL responses could be detected for 17 out of 20 (85%; see Table IV) of the degenerate ...
12
Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs
... To enhance the stability of the liposomes, researchers also used solid particles as a scaffold or core for the lipid bilayer, also called supported lipid bilayers (SLBs).[64] Different SLB systems have been developed ...
13
Contrasting Roles of the PD-1 Signaling Pathway in Dendritic Cell-Mediated Induction and Regulation of HIV-1-Specific Effector T Cell Functions
... novo CTL responses, caution should be taken in the design of combination therapies that include targeting the PD-1/PD-L1 axis to avoid the potential negative impact of limiting primary T cell ...primary ...
15
Identification of Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Specific Cytotoxic T-Lymphocyte Epitopes and Evaluation of Reconstitution of KSHV-Specific Responses in Human Immunodeficiency Virus Type 1-Infected Patients Receiving Highly Active Antiretroviral Therapy
... specific CTL activity directed at peptides from both lytic and latent proteins is an important factor in the pathogenesis of EBV-associated diseases ...KSHV-specific CTL target epitopes which exclude ...
7
Effect of the V3 Loop Deletion of Envelope Glycoprotein on Cellular Responses and Protection against Challenge with Recombinant Vaccinia Virus Expressing gp160 of Primary Human Immunodeficiency Virus Type 1 Isolates
... cellular responses against HIV-1 (29), possibly explaining the antigenic variation associated with this ...immune responses, vaccine strategies including dampening of the immunodominant epitopes through ...
11
Human Papillomavirus Type 16 L1 Capsomeres Induce L1-Specific Cytotoxic T Lymphocytes and Tumor Regression in C57BL/6 Mice
... immune responses following ...and CTL responses that were measured by different in vitro assays (specific for the newly identified L1-derived CTL epitope 165 AGVDNRECI 173 ) and in an in vivo ...
11
CD4+ Target Cell Availability Determines the Dynamics of Immune Escape and Reversion In Vivo
... T-cell responses arise simultaneously: some responses peak early in infection (around the peak of viral load), while others may develop slowly in chronic infection ...For CTL responses that ...
11
Increased immunogenicity of inactivated influenza virus vaccine containing purified surface antigen compared with whole virus in elderly women.
... Magnitude and virus specificity of CTL responses following immunization of elderly volunteers with trivalent inactivated influenza virus. vaccine containing purified surface antigen (ope[r] ...
5
Frequent and Variable Cytotoxic-T-Lymphocyte Escape-Associated Fitness Costs in the Human Immunodeficiency Virus Type 1 Subtype B Gag Proteins
... traditional CTL escape mutations, we examined 3 mutations (A81T, D260E, and D312E) that displayed a distinct HLA class I association in which the escape mutation (T81, E260, or E312) reflects the high-frequency ...
14
Induction of Mucosal Protection against Primary, Heterologous Simian Immunodeficiency Virus by a DNA Vaccine
... frequency CTL responses against both dominant and sub- dominant epitopes (6), making this strategy an attractive, com- mercially viable alternative to live attenuated HIV ...
9
Prior Vaccination Increases the Epitopic Breadth of the Cytotoxic T-Lymphocyte Response That Evolves in Rhesus Monkeys following a Simian-Human Immunodeficiency Virus Infection
... high-frequency CTL responses to domi- nant epitopes (0.1 to 0.4%), but responses to subdominant epitopes were of a substantially lower frequency ...subdominant CTL responses could ...
6