CTLA-4
Original Article Therapeutic effects of CTLA-4-Ig on diabetic nephropathy in type 2 diabetes mellitus rats ascribed to protection of CTLA-4-Ig on podocytes
... of CTLA-4-Ig on diabetic nephropathy (DN) and potential mechanism in rats with type 2 diabetes mellitus ...the CTLA-4-Ig group. In the CTLA-4-Ig group, rats were treated with ...
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Original Article Association between CTLA-4 polymorphisms and osteosarcoma susceptibility
... that CTLA-4 gene is closely associated with many diseases including OS ...in CTLA-4 gene can affect CTLA-4 ...of CTLA-4 gene can result in the occurrence and ...
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Original Article Prognostic value of PDCD-1 and CTLA-4 in ovarian cancer patients
... and CTLA-4, this study lacks long-enough follow-up data and therefore the impact of both PDCD-1 and CTLA-4 on prognosis could not be accu- rately ...and CTLA- 4, careful ...
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Sequencing CTLA 4 blockade with cell based immunotherapy for prostate cancer
... checkpoint CTLA-4, has recently been evaluated in two randomized, Phase III, placebo-controlled trials in men with metastatic, castrate-resistant prostate can- ...
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The soluble CTLA-4 receptor and its role in autoimmune diseases: an update
... of CTLA-4, and three on the presence of sCTLA-4 in the serum of autoimmune patients, have been published [11], underlining the high level of inter- est in these ...between CTLA-4 poly- ...
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A mathematical modelling tool for unravelling the antibody-mediated effects on CTLA-4 interactions
... of CTLA-4 and CD-28 with their B7- ligands in the context of a potentially dynamic synaptic microenvironment ...to CTLA-4 blocking antibodies and the consequent effects on complex formation at ...
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Collagen induced arthritis in the BB rat Prevention of disease by treatment with CTLA 4 Ig
... by CTLA-4-Ig, a soluble form of CTLA-4 which binds with high avidity to the CD28 ligands, B7-1 and ...that CTLA-4-Ig treatment prevents clinical and histological manifestations ...
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CTLA-4 blockade: therapeutic potential in cancer treatments
... Combinations of CTLA-4 antibodies with vaccines were also investigated, in attempts at overcoming tolerance. Pep- tide vaccines have been used in the past in treatment regi- mens for melanoma, where ...
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Trans-endocytosis of CD80 and CD86:a molecular basis for the cell-extrinsic function of CTLA-4
... into CTLA-4 expressing ...with CTLA-4 + CHO cells in the presence or absence of 10 nM Bafilomycin ...Singlet CTLA-4 expressing cells were analyzed for GFP acquisition by ...
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Selective CD28 blockade attenuates CTLA-4–dependent CD8+ memory T cell effector function and prolongs graft survival
... for CTLA-4, a process that may inadvertently boost effector ...preserves CTLA-4 coinhibition confers improved allograft survival in sensitized recipients as compared with CTLA-4 ...
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Radiotherapy enhances responses of lung cancer to CTLA-4 blockade.
... Formenti et al. have recently reported the clinical outcomes and translational readouts of a trial of the anti-CTLA-4 inhibitor, ipilimumab, in combination with palliative radiotherapy in 39 patients with ...
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IMPACT OF CTLA-4 AND NOD2/CARD15 GENE VARIATIONS ON GRAFT- VERSUS-HOST DISEASE AFTER ALLOGENEIC HSCT: A STRUCTURED REVIEW
... of CTLA-4 and NOD2/CARD15 genes and the incidence and severity of ...in CTLA-4 gene have been associated with the onset and clinical presentation of some diseases, such as insulin-dependent ...
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The efficacy and safety of combination of PD-1 and CTLA-4 inhibitors: a meta-analysis
... Given that PD-L1 expression strongly relates with efficacy of α-PD-1 treatment. Therefore, we investi- gated efficacy of combination therapy in different PD-L1 expression statuses. Notably, in the context of high PD-L1 ...
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Genetic polymorphisms in PTPN22, PADI 4, and CTLA 4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene environment interactions with heavy cigarette smoking
... [9,11-16], CTLA- 4 (CT60, rs3087243) [17,18], and PADI-4 (PADI4_94, rs2240340) [8] to be associated with increased risk for ...of CTLA-4 and PADI-4 polymor- phisms with RA risk ...
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Original Article CTLA-4 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease
... of CTLA-4 on the T-cell surface and impairs inhibitory function and contributes to the patho- genesis of some autoimmune diseases and multiple types of cancer [4, ...of CTLA-4 +49A/G ...
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The effect of CTLA-4 A49G polymorphism on rheumatoid arthritis risk: a meta-analysis
... All of the main results of the meta-analysis were shown in Table 2. Overall, significant associations between CTLA-4 A49G polymorphism and RA risk was found (GG vs. AA: OR = 1.13, 95% CI = 1.03–1.23; GA vs. ...
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Increased production of soluble CTLA 4 in patients with spondylarthropathies correlates with disease activity
... these CTLA-4 transcripts in SpA is not known but one may hypoth- esize that genetic background could play a role ...sCTLA- 4, CTLA-4 mRNA spliced form, and CTLA-4 ...by ...
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Tumor CTLA-4 overexpression predicts poor survival in patients with nasopharyngeal carcinoma
... of CTLA-4 and CD28 in tumor cells was evaluated in tumor samples obtained before treatment from 191 previously untreated, histologically confirmed, stage I–IVc (according to the 7th edition of the AJCC/UICC ...
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CTLA-4 correlates with immune and clinical characteristics of glioma
... and CTLA-4 have shown striking success against a variety of solid ...for CTLA-4 were observed in our study. We found that CTLA-4 tended to be expressed at higher level in higher ...
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Original Article Relationship between CTLA-4 +49A>G polymorphism and the risk of lung adenocarcinoma in a Chinese Han population
... The CTLA-4 gene is located on chromosome ...for CTLA-4, only the +49A>G polymorphism can cause changes in the amino acid sequence of ...the CTLA-4 +49A>G polymorphism was ...
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