CTLA4-Ig
Effects of CTLA4-Ig on human monocytes
... the mechanisms of induction of apoptosis in target cells, in which Fc receptors on effector cells play a pivotal role [6]. Since the addition of intact IgG almost completely abrogated the capacity of abatacept to induce ...
6
CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients
... that CTLA4-Ig inhibits early T cell–dependent alloantibody responses as well as recall responses ...extended CTLA4-Ig treatment on graft-reactive memory T cell ...that CTLA4-Ig ...
13
Effects of CTLA4 Ig treatment on circulating fibrocytes and skin fibroblasts from the same systemic sclerosis patients: an in vitro assay
... particular with their activation and differentiation into fi- broblasts/myofibroblasts. The decrease in the gene ex- pression of the main phenotypic markers of activated fibrocytes (COL I and CXCR4), together with the ...
9
The evolving clinical profile of abatacept (CTLA4–Ig): a novel co stimulatory modulator for the treatment of rheumatoid arthritis
... diseases. CTLA4–Ig has been studied in preclinical transplant models as well as in models of systemic lupus erythematosus, experimental allergic encephalitis (a murine model of multiple sclerosis), and ...
5
CTLA4 Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production
... by CTLA4-Ig on cultures of both RA synovial macrophages (RA SM), and of macrophages differentiated from THP-1 cells ...of CTLA4-Ig on co-cultures of RA SM and M with activated T cells were ...
10
Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model
... contrast, CTLA4-Ig treatment produced a marked decrease in both cellular infiltrates and inflammatory changes within the bronchial mucosa ...that CTLA4-Ig treatment induced a significant ...
8
CD28 B7 blockade prevents the development of experimental autoimmune glomerulonephritis
... of CTLA4 (CTLA4-Ig) that binds to both ...native CTLA4-Ig or mutant CTLA4-Ig (Y100F-Ig), which selectively blocks ...Native CTLA4-Ig treatment ...
10
Conjugation of Lentivirus to Paramagnetic Particles via Nonviral Proteins Allows Efficient Concentration and Infection of Primary Acute Myeloid Leukemia Cells
... produced from 293T cells by transient transfection of helper functions with either LV.bla vector plasmids (VSV-G ⫹ LV.bla and Ampho ⫹ LV.bla) or B7.1-encoding LV.B7.1bla vector plasmids (VSV- G ⫹ LV.B7.1bla and Ampho ⫹ ...
5
Antiviral immune responses in CTLA4 transgenic mice.
... soluble CTLA4 may be in- jected up to 48 h after immunization with keyhole limpet hemocyanin and still be able to block the response effectively ...that CTLA4 interferes probably mostly with expansion ...
6
The immune response of stem cells in subretinal transplantation
... expressing CTLA4-Ig and PD-L1 before and after differentiation, and showed that human ESC-derived allografts could be implanted without the need for systemic immune ...
7
CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection
... (allografts) and C57BL/6 tracheas transplanted subcutaneously into the backs of C57BL/6 mice (synge- neic control) (32, 33, 36). Each mouse was subcutaneously transplanted with 2 tracheas. The small mole- cule CCR4 ...
18
B7 dependent T cell costimulation in mice lacking CD28 and CTLA4
... We wish to thank Sumi Scott, Baolin Chang, Frans Hofhuis, and Sandra Jainandunsing for expert techni- cal assistance; Scott Boyd and Andy Chen for their con- tributions to making the targeting construct; Peter Libby for ...
8
IG I3 1005 B and the Boundary of Melite and Kollytos
... Investigation of the possibility that B marked a deme boundary, prefaced by a discussion of deme formation and territoriality, yields evidence that the ancient street[r] ...
37
Blockade of lymphotoxin beta receptor signaling reduces aspects of Sjögren's syndrome in salivary glands of non obese diabetic mice
... Introduction The lymphotoxin-beta receptor (LTR) pathway is important in the development and maintenance of lymphoid structures. Blocking this pathway has proven beneficial in murine models of autoimmune diseases such ...
12
Preoperative Interventions for Alcohol and Other Recreational Substance Use: A Systematic Review and Meta-Analysis
... As there were no significant overall effects on perioperative complications, mortality and length of hospital stay, this may be explained by intervention timing. Some studies neglected to report the time from ...
18
IG V 1, 16 and the Gerousia of Roman Sparta
... During Sparta's forty years under an Achaean constitution, the ephors were finally displaced as sole rulers by the synarchia, a joint committee consisting of the ephors them- selves an[r] ...
11
Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene
... causes IG-DMR methylation in Gtl2 KO embryos. However, in our study, the IG- DMR was unmethylated in Gtl2 KO oocytes even though transcription of the neo was active in the oocytes ...the IG-DMR in ...
10
Evidence Suggesting Persistence of Nephritogenic Immunopathologic Mechanisms in Patients Receiving Renal Allografts
... developed Ig deposition on allograft glomeruli, although direct IF of native kidneys was ...linear Ig deposition on allograft glomeruli was the result of antiglomerular basement membrane (GBM) antibodies, ...
9
Biochemical and Biophysical Characterizations of Immunoglobulin Superfamily Receptors Neogenin and L1
... the Ig superfamily, was found to guide axon growth and regulate neuronal survival through interacting with repulsive guidance molecule A (RGMa) (33, 34), the closest homolog of ...
147
Comparison of the passive prophylactic effect of bovine milk immunoglobulin fed either as a bolus or continuously against diarrhoea caused by Escherichia coli K88 using piglets as models : a thesis presented in partial fulfilment of the requirements for the degree of Master of Animal Science at Massey University, Palmerston North, New Zealand
... Intravenous administration of Ig is used to treat primary immuno-deficiencies, (Imbach et al. , 1 98 1 ; Levin et al., 1 98 1 ; Stephan & Dichtelmuller, 1 983; Baumgartner & Glauser, 1 987; Kurlander, 1 ...
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