CTLs, Cytotoxic T-lymphocytes
Dynamic changes of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and natural killer T (NKT) cells in patients with acute hepatitis B infection
... blood cytotoxic T lymphocytes (CD3 + CD8 + ) in AHB patients in the early stage of infection were higher than in the healthy control group and among CHB ...+ lymphocytes might reflect ...
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Molecular Imaging in Tracking Tumor-Specific Cytotoxic T Lymphocytes (CTLs)
... in T cells employs an indi- rect strategy: a luciferase enzyme is expressed in the cell; when its substrate luciferin is introduced, lucif- erase can catalyze the oxidation of luciferin in the presence of ATP and ...
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Human Papillomavirus Type 16 (HPV-16) Virus-Like Particle L1-Specific CD8+ Cytotoxic T Lymphocytes (CTLs) Are Equally Effective as E7-Specific CD8+ CTLs in Killing Autologous HPV-16-Positive Tumor Cells in Cervical Cancer Patients: Implications for L1 Dendritic Cell-Based Therapeutic Vaccines
... ⴙ T lymphocytes responses in cervical cancer patients, L1 VLP-loaded dendritic cells (DCs) were used to stimulate peripheral blood lymphocytes from cervical cancer patients and such responses were ...
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<p>Resistance Mechanism of PD-1/PD-L1 Blockade in the Cancer-Immunity Cycle</p>
... receptor; CTLs, Cytotoxic T lymphocytes; CTLA-4, Cytotoxic T-lymphocyte-associated antigen-4; DCs, Dendritic cells; DDR, DNA damage repair; EGFR, Epidermal growth factor ...
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Immunomodulatory effects of Rhipicephalus haemaphysaloides serpin RHS2 on host immune responses
... 2; CTLs: cytotoxic T lymphocytes; BMDC: bone marrow-derived dendritic cells; DCs: dendritic cells; OVA: ovalbumin; TBD: tick-borne diseases; IL-2: interleukin 2; IL-4: interleukin 4; IFN-γ: ...
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DNA vaccination for prostate cancer: key concepts and considerations
... cancer; CTLs: Cytotoxic T lymphocytes; DNA: Deoxyribonucleic acid; DOM: Domain of fragment C tetanus toxin; DTH: Delayed-type hypersensitivity; EP: Electroporation; FDA: US food and drug ...
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Engineering Nanoparticles for Targeted Remodeling of the Tumor Microenvironment to Improve Cancer Immunotherapy
... antigen-4; CTLs: cytotoxic T lymphocytes; DCs: dendritic cells; ECM: extracellular matrix; EGFR: epidermal growth factor receptor; EPR: enhanced permeability and retention; ERBB2IP: erbb2 ...
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Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTL precursors after rotavirus infection.
... 65, 1991 tinal and nonintestinal lymphocytes after rotavirus infection, adult mice were inoculated orally or via the hind footpad with RRV; virus-specific cytotoxic activities in intesti[r] ...
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Tim-3 expression and its role in hepatocellular carcinoma
... CTLA-4: Cytotoxic T lymphocyte-associated protein 4; CTLs: CD8+ cytotoxic T lymphocytes; DC: Dendritic cell; EMT: Epithelial-mesenchymal transition; EpCAM: Epithelial cell ...
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Overlapping cytotoxic T-lymphocyte and B-cell antigenic sites on the influenza virus H5 hemagglutinin.
... 6246 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest To define the recognition site of cytotoxic T lymphocytes CTLs on influenza virus H5 hemagglutinin HA, an H5 HA-spe[r] ...
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Validation of analytical methods in compliance with good manufacturing practice: a practical approach
... and Cytotoxic T Lymphocytes (CTLs), both cell therapy products that we will produce, in GMP conditions, for clinical trials of immunotherapy and regenerative medicine, and dendritic cells ...
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Increased frequency of antigen specific CD8+ cytotoxic T lymphocytes infiltrating an Epstein Barr virus–associated gastric carcinoma
... ated solid or medullary types (9–11). When EBV-encod- ed RNAs (EBERs) were applied for in situ hybridization, positive lesions were characterized by the presence of sig- nals in almost all carcinoma cells and by the ...
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Cytotoxic T lymphocytes form an antigen independent ring junction
... the T cell temporarily stops its hunting, which might reduce the number of cells it can scan, but the benefit may be in a reduction of missed targets with low amounts of MHCp complex- es or those MHCp complexes ...
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Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys.
... 1707 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest To assess the possible role of cytotoxic T lymphocytes CTLs in containing the spread of human immunodeficiency virus[r] ...
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Prognostic significance of PD-L1 expression and CD8+ T cell infiltration in pulmonary neuroendocrine tumors
... Cytotoxic lymphocytes (CTLs), which play a critical role in the anticancer response, are actively suppressed in the tumor microenvironment ...Some CTLs man- age to be released into ...
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MUC1 Antigen Specific CD8 T Lymphocytes Targeting MCF7 and MDA MB 231 Human Breast Adenocarcinoma Cell Lines
... MUC1-specific CTLs had the ability to induce cytotoxicity over human breast adenocarcinoma cell ...to CTLs. CTLs that had been activated against MUC1 79-87 TLAPATEPA peptide, demonstrated greater ...
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The Cell Biology of Systemic Hyperinflammation Resulting from Failed Cytolytic Target Cell Killing
... All the other FHL mutations appear to affect some aspect of cytotoxic granule exocytosis, resulting in impaired target cell killing by cytolytic T lymphocytes CTLs and/or natural killer [r] ...
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Structural and functional consequences of alveolar cell recognition by CD8(+) T lymphocytes in experimental lung disease
... 1 T cells infiltrate the lung in many clinical conditions, particularly in interstitial lung ...1 T cells might be playing in the pathogenesis of in- flammatory lung disease is unclear at present, as is the ...
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A phase II trial of stereotactic body radiotherapy with concurrent anti PD1 treatment in metastatic melanoma: evaluation of clinical and immunologic response
... regulatory T cells, den- dritic cell and myeloid derived suppressor cell subsets, next to functional analysis looking at shifts in Th1/Th2/Th17 polarization as a function of treatment [11, ...
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Direct Toll like receptor 2 mediated co stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease
... enriched T cell populations were incu- bated in the presence of plate-bound anti-CD3 mAb, at concentrations known to be insufficient for the induction of proliferation [23], together with either Lip-OspA, its ...
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