Cu, Zn superoxide dismutase
Surface-exposed proteins of pathogenic mycobacteria and the role of cu-zn superoxide dismutase in macrophages and neutrophil survival
... The selective biotinylation of surface-exposed proteins using membrane impermeable reagents has become an important tool in the study of this subset of the cellular proteome. This study adapted the aforementioned method ...
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Altered expression of hypothetical proteins in hippocampus of transgenic mice overexpressing human Cu/Zn-superoxide dismutase 1
... The enzyme Cu/Zn-superoxide dismutase 1 (SOD1; E.C.1.15.1.1), which catalyses the conversion of superox- ide radicals into the less toxic hydrogen peroxide (H 2 O 2 ) plays an important role ...
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Lipid Rafts in Cryptococcus neoformans Concentrate the Virulence Determinants Phospholipase B1 and Cu/Zn Superoxide Dismutase
... factor Cu/Zn superoxide dismutase (SOD1) was concentrated six- to ninefold in raft membrane fractions compared with nonraft membranes, whereas the cell wall-associated virulence factor laccase ...
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Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene
... the Cu/Zn superoxide dismutase 1 (SOD1) gene ...eliminating superoxide, an undesirable byproduct of oxidative phosphorylation and a potential source of oxidative damage, the fact that ...
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Production and Characterization of RecombinantAspergillus fumigatus Cu,Zn Superoxide Dismutase and Its Recognition by Immune Human Sera
... The Cu,Zn superoxide dismutase (SOD) of Aspergillus fumigatus has previously been purified and shown to be immunoreactive to the sera of patients with aspergillosis; however, the purification ...
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Pivotal role of Cu,Zn superoxide dismutase in endothelium dependent hyperpolarization
... that Cu,Zn-superoxide dismutase (Cu,Zn-SOD) plays a pivotal role in endothelium-dependent hyperpolarization, using control and Cu,Zn-SOD–/– ...in ...
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The Megavirus Chilensis Cu,Zn-Superoxide Dismutase: the First Viral Structure of a Typical Cellular Copper Chaperone-Independent Hyperstable Dimeric Enzyme
... (44). We then performed a structural alignment using the 3DCoffee server (45) and included the Saccharomyces cerevisiae SOD sequence (Protein Data Bank [PDB] accession number 1SDY), human SOD se- quence (GenBank ...
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Molecular characterization of a cDNA encoding Cu/Zn superoxide dismutase from Deschampsia antarctica and its expression regulated by cold and UV stresses
... Deschampsia antarctica Desv. is a grass specie adapted to the extreme climate of the Maritime Antarctic [20], pre- senting tolerance to low temperatures usually between - 2°C to 6°C in summer and freezing in winter time ...
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Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis
... antibodies exhibited distinct reactivities in an ELISA, a part of which was previously published from our group [ 35 , 36 ], and wild-type SOD1 in the presence of copper and zinc ions as[r] ...
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Cattle serologically positive for Brucella abortus have antibodies to B. abortus Cu-Zn superoxide dismutase.
... Lane 1, amido black-stained blot of BCSP; lane 2, immunoblot incubated with positive control serum from an experimen- tally infected cow (cow 47); lane 3, immunoblot with a negative cont[r] ...
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Copper Chaperone for Cu/Zn Superoxide Dismutase is a sensitive biomarker of mild copper deficiency induced by moderately high intakes of zinc
... of Zn affect Cu transport and reduce Cu efflux at the basolateral side [38], suggesting that Zn may block absorption of Cu by affecting the activity of a Cu trans- ...improved ...
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Rat lung Cu,Zn superoxide dismutase Isolation and sequence of a full length cDNA and studies of enzyme induction
... explore the regulation of these increases, we measured rat lung Cu,Zn SOD synthesis and activity. We also cloned and sequenced a rat lung Cu,Zn SOD cDNA that was used to measure ...
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A Comparison of the Structure and Function of the Highly Homologous Maize Antioxidant Cu/Zn Superoxide Dismutase Genes, sod4 and Sod4A
... FIGURE 7.-RNA blot analysis of L'jod4 and Sod4A mRNA levels in leaf and stem tissue isolated from seedlings treated with paraquat in the light and dark.. Twelveday seedli[r] ...
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Transduction of Cu, Zn superoxide dismutase mediated by an HIV 1 Tat protein basic domain into human chondrocytes
... and superoxide, but that only superoxide mediated IL-1 induced NF-kB activation and iNOS expression ...or superoxide is responsible for stimulation of MMP in ...
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Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis
... In this study, we successfully prepared anti-SOD1 olig/int anti- bodies exclusively recognizing the disulfide-crosslinked SOD1 oligomers in vitro and then found that those anti- bodies d[r] ...
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Cloning and constitutive expression of Deschampsia antarctica Cu/Zn superoxide dismutase in Pichia pastoris
... heterologous Cu/ZnSOD ...antarctica Cu/ZnSOD (Figure ...mature Cu/ZnSOD fused with the epitope-myc and 6xHis-tag and two additional bands of 18 and 15 ...
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Cu/Zn superoxide dismutase expression in the postnatal rat brain following an excitotoxic injury
... total Cu/Zn SOD immunoreactivity in neuronal cells, which returned to basal levels 24 hours after the lesion and increased significantly thereafter due to expres- sion in astroglial ...neuronal ...
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Genotype phenotype relationship in hereditary amyotrophic lateral sclerosis
... SOD1: Cu/Zn superoxide dismutase; IAHSP: Infantile ascending hereditary spastic paraplegia; JPLS: Juvenile primary lateral sclerosis; JALS: Juvenile amyotrophic lateral sclerosis; SETX: ...
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Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease
... disease; Cu/Zn SOD: Cu/Zn superoxide dismutase; CVD: Cardiovascular disease; ECs: Endothelial cells; F1 + 2: Prothrombin fragments 1 + 2; FLD: Fluorescence detector; H2O2: ...
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Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster.
... SETO, HAYASHI and TENER (1 990) examined the effects of increasing Cu/ Zn superoxide dismutase levels on aging in Drosophila and found that, if affected at all, life span was [r] ...
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