Cuprizone-induced demyelination
CXCR3 modulates glial accumulation and activation in cuprizone-induced demyelination of the central nervous system
... cuprizone-induced demyelination and glial activation dif- fer widely between the brain areas ...although cuprizone-induced myelination is most distinct in this ...of ...
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Strain differences in cuprizone induced demyelination
... by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people ...the cuprizone toxicity model is widely ...to cuprizone-induced ...
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Thalamocortical-auditory network alterations following cuprizone‐induced demyelination
... and demyelination in different brain regions, preferentially in the corpus ...callosum. Cuprizone-induced demyelination is usually followed by complete remyelination within a few ...in ...
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Fingolimod Attenuates Splenocyte Induced Demyelination in Cerebellar Slice Cultures
... to cuprizone-induced demyelination [25], although no deficits in myelination state has been reported for S1PR5-null mice ...In cuprizone and LPC models of demyelination, FTY720 has not ...
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Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model
... in cuprizone fed animals ...of cuprizone induced demyelination coin- cides with substantial upregulation of BBB-disrupting pro-inflammatory ...
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EBI2 receptor regulates myelin development and inhibits LPC induced demyelination
... induce demyelination in vivo [24, ...nerve induced inflammation, axonal damage, and demyelin- ation ...expression induced inflammation, breakdown of the BBB, activation of astrocytes and microglia, ...
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Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model
... during cuprizone- induced demyelination do not exert beneficial effects on remyelination ...and demyelination, observed in this ...inflammation- induced oligodendrocyte death and/or ...
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Butyrate suppresses demyelination and enhances remyelination
... in demyelination [34, 35]. In a cuprizone-induced demyelination model, microglia accumulated into demyelinating lesions and promoted an inflammatory response through the pro- duction of ...
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Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease
... Previously, we reported that 2ccPA promotes neurite outgrowth and enhances neuronal survival via a signal- ing pathway similar to that of NGF [11]. Therefore, it is possible that 2ccPA exerts protective effects against ...
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Anti-inflammatory therapy by ibudilast, a phosphodiesterase inhibitor, in demyelination of twitcher, a genetic demyelination model
... the demyelination was milder in all of the treated ...a cuprizone-induced demyelination model, due to a reduced number of proliferating OL progenitors [45], since the signal transduction of ...
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Central nervous system Toll like receptor expression in response to Theiler's murine encephalomyelitis virus induced demyelination disease in resistant and susceptible mouse strains
... a sterile syringe fitted with a William's collar. The injec- tion is made halfway between the back of the eye and the ear, at a 45 degree angle from the top of the skull. Infec- tion was confirmed by in situ ...
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Galactosylsphingosine (psychosine) induced demyelination is attenuated by sphingosine 1 phosphate signalling
... of demyelination and are a unique feature of Krabbe disease (Suzuki, ...widespread demyelination seen in Krabbe disease is due to apoptotic processes as well as aberrant inflammatory response (Giri et ...
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Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice.
... To determine whether MHCconferred resistance to TMEV-induced demyelination is inherited as a recessive or dominant trait, we infected F1 hybrid progeny mice derived from crosses between [r] ...
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Region-specific interneuron demyelination and heightened anxiety-like behavior induced by adolescent binge alcohol treatment
... treatment induced behavioral changes associated with demyelination in different brain ...ABET induced a significant reduction of parvalbumin-positive (PV+) GABAergic interneurons and myelin density ...
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Netrin 1 contributes to vascular remodeling in the subventricular zone and promotes progenitor emigration after demyelination
... LPC-induced demyelination of the CC. (A) An LPC-induced demyelinated lesion is clearly detectable in the CC by the absence of GFP expression (delineated by a dotted line) in plpGFP transgenic mice 3 ...
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Tongue fasciculations with denervation pattern in osmotic demyelination syndrome: a case report of diagnostic dilemma
... osmotic demyelination syndrome and MRI showed abnormal signal intensity within the central pons and basal ...osmotic demyelination syndrome with long-term ...
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Lysolecithin induced demyelination in primates: preliminary in vivo study with MR and magnetization transfer
... cerebral matrix destruction with small edema. In addition lesions were extensive, especially on the animal M2, with an extension in the tempo- ral lobe at a distance from the site of injection (centrum semiovale). This ...
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Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination
... is induced following ER stress and the reported link between CRT and autoimmunity, in the context of rheumatoid arthritis [14], prompted us to examine the expression of CRT and other markers of ER stress in an ...
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Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination
... antibody-induced demyelination and inflammatory ...antibody-mediated demyelination and to prevent inflammatory responses induced by IFN-γ and ...
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Multiple nivolumab-induced CNS demyelination with spontaneous resolution in an asymptomatic metastatic melanoma patient
... So far, CNS demyelination in association with ICPis treat- ment have not been reported in large cohorts of patients [21, 22], but only in few isolated cases [16–18]. Unlike in the case reported here, they were all ...
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