Cutaneous T-cell lymphoma
Role of denileukin diftitox in the treatment of persistent or recurrent cutaneous T-cell lymphoma
... recurrent cutaneous T-cell lymphoma (CTCL), a rare lymphoproliferative disorder of the ...bearing T-cells. Historically, immunotherapy targeting malignant T-cells including ...
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Original Article Effects of acitretin in combination with interferon on human cutaneous T cell lymphoma Hut78 cells
... Abstract: Objective: This study aimed to investigate the effects of acitretin A and/or interferon-α (IFN-α) on the prolif- eration of human cutaneous T cell lymphoma (CTCL) cells (Hut78) and ...
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<p>Mogamulizumab: a new tool for management of cutaneous T-cell lymphoma</p>
... of T-cell lymphomas is often to use regimens active in B-cell lymphomas, but this approach has suffered from lack of an effective T-cell-directed monoclonal antibody to use in place of ...
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Human immunodeficiency virus-positive secondary syphilis mimicking cutaneous T-cell lymphoma
... be cutaneous T-cell lymphomas on histological analyses, they lacked T-cell receptor J γ rearrangement; moreover, immunohistochemical analyses confirmed the presence of ...mimicked ...
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Atypical Cutaneous Lymphoproliferative Disorder: A Fatal Mimic of Cutaneous T Cell Lymphoma in a Patient with HIV Infection
... alternative cutaneous T-cell lymphoma (CTCL), including Sézary’s syndrome and adult T-cell leukemia/lymphoma ...atypical T-cells in peripheral blood and hepatosple- ...
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Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells
... of cutaneous T cell lymphoma (CTCL) [1, 2], ef- fective treatment options for advanced mycosis fungoides (MF) and Sézary syndrome (SS)—the two most common types of CTLC—are still ...and ...
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Mechanisms of lymphocytotoxicity induced by extracorporeal photochemotherapy for cutaneous T cell lymphoma
... photochemotherapy for cutaneous T cell lymphoma is apparently mediated by DNA damage, subsequent poly (ADP-ribosyl)ation and adenine nucleotide depletion. It is not known how the DNA damage ...
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Disruption of CCL20-CCR6 interaction inhibits metastasis of advanced cutaneous T-cell lymphoma
... Cutaneous T-cell lymphoma (CTCL) is mainly comprised of mycosis fungoides (MF) and Sezary syndrome (SzS) [14-17]. MF is the most common form of CTCL and a good model for understanding the ...
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The cutaneous T cell lymphoma, mycosis fungoides, is a human T cell lymphotropic virus associated disease A study of 50 patients
... the cutaneous T cell lymphoma, mycosis fungoides (MF), and its leukemic variant, the Sézary syndrome, are caused by the human T lymphotropic virus ...mononuclear cell (PBMC) ...
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Trends in the treatment of cutaneous T-cell lymphoma – critical evaluation and perspectives on vorinostat
... particularly cutaneous T-cell lymphoma ...malignant T cells, inhibition of angiogenesis, suppression of signal transducer and activator of transcription proteins, and up-regulation of ...
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Low Dose Total Skin Electron Beam Radiation in Cutaneous T Cell Lymphoma: Review
... The etiology of cutaneous T cell lymphoma (CTCL) remains largely unknown. However, it is thought to arise in the setting of chronic antigenic stimulation resulting in uncontrolled clonal ...
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Romidepsin in the treatment of cutaneous T-cell lymphoma
... of cell-dependent kinase (cdk) inhibitors like p21/p27 and downregulation of cyclinD 1 ; ii) acetylation of non- histone proteins, including STAT-3, RelA/p65, p53, HIF-1 α , Bcl-6, and Hsp 90, in a way that ...
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Original Article Pharmacogenetic Contribution of Leptin Gene Polymorphism in Cutaneous T-Cell Lymphoma
... adenocarcinoma and squamous cell cancer [13] as well as with higher risk for prostate cancer [14]. On the contrary, a significantly increased risk of breast cancer was associated with genotypes GA and GG in ...
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Diagnosis of cutaneous T cell lymphoma by use of monoclonal antibodies reactive with tumor associated antigens
... determined by radioimmunoassay (RIA) and indirect immunofluorescence (IIF). BE1 reacted significantly (P less than or equal to 0.001) with leukemic CTCL lymphocytes and with CTCL cells from infiltrated lymph nodes (RIA, ...
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Th17 cytokine differentiation and loss of plasticity after SOCS1 inactivation in a cutaneous T-cell lymphoma
... > T transitions occurring at CpG sites. C > T enrichment of mutational signatures, for which our sequencing data provide some support, has been attributed to spontaneous deamination of ...
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Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma
... malignant T cells, we took two ...malignant T cells spontaneously synthesize IL-6 but not IL-1β (Figure 6 and data not shown), we examined the effect of Etanercept on the spontaneous production of IL-6 by ...
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Loss of nuclear pro–IL 16 facilitates cell cycle progression in human cutaneous T cell lymphoma
... malignant T cells in advanced CTCL is likely a combination of both dysregulated T cell proliferation as well as a decrease in the apoptotic ...defective T receptor signaling pathways, ...
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Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma
... Further characterization of romidepsin revealed that it works on DNA within the cell nucleus as a histone deacety- lase inhibitor. By altering the structure of DNA, it causes activation and/or repression of key ...
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Molecular aspects of cutaneous T-cell lymphoma : genetic alterations underlying clinical behavior
... Only CNAs characterized by gain or loss of at least 2 clones were taken into consideration. The nearby borders of adjacent clones were chosen to delineate MCRs. Copy number was divided into the categories gain, normal, ...
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Management of cutaneous T cell lymphoma: new and emerging targets and treatment options
... several lymphoma types, including mycosis fungoides and Sézary ...B cell lymphoma-2 (Bcl-2) family. Malignant CD4 + T cells from cutaneous lesions and peripheral blood samples in ...
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