Cutaneous T-cell lymphomas
Vorinostat approved in Japan for treatment of cutaneous T-cell lymphomas: status and prospects
... Patients with previously untreated stage IIIB or IV nonsmall cell lung cancer were treated with carboplatin and paclitaxel combined with either vorinostat or a placebo. In 94 evaluable patients, the confirmed ...
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<p>Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel</p>
... Abstract: Mycosis fungoides (MF) is a low-grade cutaneous lymphoma accounting for more than half of primary cutaneous T-cell lymphomas (CTCLs). Due to the rarity of CTCL, random- ized ...
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Management of cutaneous T cell lymphoma: new and emerging targets and treatment options
... Abstract: Cutaneous T cell lymphomas (CTCL) clinically and biologically represent a heterogeneous group of non-Hodgkin lymphomas, with mycosis fungoides and Sézary syndrome being the ...
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Clinicopathological Correlation and Outcome in peripheral T cell lymphomas (PTCL): A Retrospective study
... Peripheral T-cell lymphomas (PTCLs), is a heterogeneous group of non Hodgkin lymphoma (NHL) originating from ...common cutaneous T cell lymphomas ...Overall T ...
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Original Article Pharmacogenetic Contribution of Leptin Gene Polymorphism in Cutaneous T-Cell Lymphoma
... Abstract: Leptin has recently attracted more attention due to its specific effects in the pathogenesis of malignancies. The aim of this study was to investigate the possible association between variants of -2548 G/A ...
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Clinicopathological Features of Cutaneous Lymphomas and T-Cell Receptor Gamma Gene Rearrangement Studies in Early Stage Mycosis Fungoides
... Cutaneous lymphomas (CL) are extranodal non-Hodgkin lymphoma of malignant, mature T and B lymphocytes that target the skin and have various distinct clinicopathological entities with varied natural ...
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Molecular advances in cutaneous T-cell lymphoma
... Cutaneous T cell lymphomas (CTCLs) are malignancies derived from skin- homing T cells. Mycosis fungoides (MF), the most common CTCL, typically presents with patches and plaques ...
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The diagnosis and management of NK/T-cell lymphomas
... NK/T-cell lymphomas. Plas- macytoid dendritic cell neoplasms, formerly erroneously classified as blastoid NK-cell lymphomas, are localized mainly to the skin but may also involve ...
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Romidepsin in the treatment of cutaneous T-cell lymphoma
... peripheral T-cell lymphoma was declared to be in complete remission after the eighth cycle of romidepsin, with complete disappearance of his skin lesions and diffuse ...of T-cell ...
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Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report
... adnexal lymphomas (OALs) of MALT-type ...-specific T cells throughout the release of Sézary T cell-activating factor (SAF), thus potentiating the development of CTCL ...
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Novel therapeutic agents for cutaneous T-Cell lymphoma
... transformed T-cells ...relapsed/refractory lymphomas although the toxicity was profile was different with fatigue, anorexia, diarrhea and dehydration being the dose limited toxicities (DLTs) for patients on ...
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Selection for c-myc Integration Sites in Polyclonal T-Cell Lymphomas
... Why would there be selection against the highest levels of c-myc expression? One explanation is that there is a threshold level of c-myc RNA that is required to drive tumor cell growth, but above this threshold, ...
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Tumor progression in murine leukemia virus-induced T-cell lymphomas: monitoring clonal selections with viral and cellular probes.
... To evaluate whether these primary T-cell lymphoma tissues are composed of oligoclonal cell populations and to monitor tumor progression, primary BALB/c and C57BL T-cell lymphomas were tr[r] ...
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Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
... Fig. 1 Heterozygous loss of Bcl11b suppresses the progression, but not the initiation of ATM-deficient thymic lymphomas. a Thymic lymphoma- free survival of ATM −/− and ATM −/− Bcl11b +/− mice. Median survival of ...
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The IgH 3’ regulatory region influences lymphomagenesis in Igλ-Myc mice
... Numerous lymphomas are thus marked by proto-oncogene translocation into the IgH locus such as cyclin D1, Bcl-2 and c-myc for mantle cell lymphoma, follicular lymphoma and Burkitt lymphoma, ...
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The biology of tumor growth in the non Hodgkin's lymphomas A dual parameter flow cytometry study of 220 cases
... tumor cell populations with near-tetraploid DNA ...B cell lymphomas and among the aggressive T cell ...electronic cell volumes of the aneuploid ...large cell component ...
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Immunopathogenesis and therapy of cutaneous T cell lymphoma
... In addition to IFN-α, other approaches to enhancing the effec- tor phase of antitumor immunity are presently being utilized (Figure 6). Although limited studies have been reported following the administration of ...
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Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma
... benign T cells clarifies how it can treat both cutaneous lym- phoma and inflammatory disorders such as ...benign T cell ...benign T cells; treatment of patients with antibiotics reduces ...
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Atypical Cutaneous Lymphoproliferative Disorder: A Fatal Mimic of Cutaneous T Cell Lymphoma in a Patient with HIV Infection
... CD8+ T-cells may be re- lated to the diminished numbers of circulating CD4+ T- cells and the reciprocal regulatory processes between the two different cell types ...CD4+ T-cells and a large ...
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Emerging treatment options for early mycosis fungoides
... for Cutaneous Lymphomas, the United Stated Cutaneous Lymphoma Consortium, and the cutaneous lymphoma task force of the European Organisation for Research and Treatment of ...
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