CXC chemokine receptor
Initial Assessment of the Role of CXC Chemokine Receptor 4 after Polytrauma
... CXC chemokine receptor (CXCR)-4 agonists have been shown to attenuate inflammation and organ injury in various disease models, including ...Toll-like receptor (TLR)-2 and TLR-4 activation was ...
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Cell cycle–dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity
... functional receptor on activated T lymphocytes, named CXC chemokine receptor 3 (CXCR3) ...Another chemokine, 6Ckine, was recently found to interact with CXCR3 and to exert angiostatic ...
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Expression pattern of CXC chemokine receptor 4 is correlated with lymph node metastasis in human invasive ductal carcinoma
... the CXC chemokine family and has potent chemotactic activity for lymphocytes ...[2]. CXC chemokine receptor-4 (CCR4) is the only physiologi- cal receptor for SDF-1, and has also ...
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CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen induced arthritis
... Introduction: Chemokines and their receptors are potential therapeutic targets in rheumatoid arthritis (RA). Among these, several studies suggested the involvement of CXC chemokine 4 (CXCR4) and its ligand ...
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CXC-Chemokine Receptor 4 Is Not a Coreceptor for Human Herpesvirus 7 Entry into CD4+ T Cells
... a chemokine to its receptor, a transient dose-dependent increase in intracellular calcium concentration occurs as an essential component of the signal transduction ...CXCR4-specific chemokine SDF-1␣ ...
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Preconditioning of bone marrow-derived mesenchymal stromal cells by tetramethylpyrazine enhances cell migration and improves functional recovery after focal cerebral ischemia in rats
... therapeutic strategies for treating ischemic stroke. However, the relatively poor migratory capacity of BMSCs toward infarcted regions limited the therapeutic potential of this approach. Pharmacological preconditioning ...
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Combinatorial treatment of acute myocardial infarction using stem cells and their derived exosomes resulted in improved heart performance
... its receptor CXC chemokine receptor 4 (CXCR4) has been demonstrated to play a vital role in the recruitment of stem cells to the ischemic myocar- dium ...
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The Regulation and Interactions of the Hypoxia Inducible Factor Pathway in Carcinogenesis and Potential Cancer Therapeutic Strategies
... 2005 Epidermal Growth Factor and Hypoxia-Induced Expression of CXC Chemokine Receptor 4 on Non-Small Cell Lung Cancer Cells Is Regulated by the Phosphatidylinositol 3-Kinase/PTEN/AKT/Mam[r] ...
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SDF-1 Improves Renal Fibrosis in Type 2 Diabetes Mellitus Involving TGF-beta-mediated ECM via PI3K/AKT Signaling
... factor-1, CXC chemokine receptor 4 and F4/80 were ...factor-1, CXC chemokine receptor 4 and F4/80 was significantly increased in the kidney of db/db mice but not in C57BL/6 mice, ...
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Virologic and Immunologic Events in Hilar Lymph Nodes During Simian Immunodeficiency Virus Infection Development of Polarized Inflammation
... inflammatory CXC chemokine receptor 3 (CXCR3) ligands CXCL9, CXCL10, and CXCL11 were all consistently among the most upregulated mRNAs early and late after SIV ...
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Original Article Interaction between CXCR4 and EGFR and downstream PI3K/AKT pathway in lung adenocarcinoma A549 cells and transplanted tumor in nude mice
... CXC chemokine receptor 4 (CXCR4), a member of the G-protein-coupled receptor family, has received considerable attention since it has been demonstrated to be important in tumor metastasis ...
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T-Cell-Line-Tropic Human Immunodeficiency Virus Type 1 That Is Made Resistant to Stromal Cell-Derived Factor 1α Contains Mutations in the Envelope gp120 but Does Not Show a Switch in Coreceptor Use
... CXC chemokine receptor 4 (CXCR4) was recently shown to be a coreceptor used by T-cell-line-tropic (T-tropic) human immunodeficiency virus (HIV) strains to enter target cells (5, 27), whereas CC ...
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Study on chemotaxis and chemokinesis of bone marrow-derived mesenchymal stem cells in hydrogel-based 3D microfluidic devices
... therapeutic effect in the patients. The ability of MSCs to produce juxtacrine or paracrine factors is very important to induce regeneration from the endogenous stem cells. Studies have been done previously on some ...
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Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease
... CC-chemokine receptor 2; CCR5: CC- Chemokine receptor 5; CD11b: Cluster of differentiation 11B; CXCR3: CXC-chemokine receptor 3; CXCR4: CXC-chemokine ...
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Novel regulatory therapies for prevention of Graft-versus-host disease
... APC: antigen-presenting cells; BMT: bone marrow transplantation; CCR5: C-C chemokine receptor; CXCR3: CXC chemokine receptor 3; DC: dendritic cells; FC: facilitating cells; FoxP3: forkhe[r] ...
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Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma
... IL-8 is another important inflammatory factor secreted by TAMs in HCC. Its expression is associated with tumor growth and survival, as well as increased tumor invasion, migration and angiogenesis. Studies in MHCC97H and ...
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Characterization of CXC type chemokine molecules in early Xenopus laevis development
... Dorsal overexpression of xSDF1-alpha (CXCL12) and XCX- CLC inhibited gastrulation and neurulation in Xenopus (Fukui et al., 2007; Goto and Asashima, 2011). To investigate whether the XCXCL genes affect early ...
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Children are not little adults: just ask their hematopoietic stem cells
... of CXC chemokine ligand 12 (CXCL12, also known as stromal cell–derived factor 1 [SDF-1]), a chemokine previously implicated in stem cell trafficking to the marrow cavity and shown to be expressed by ...
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CXC and CC Chemokine Receptors on Coronary and Brain Endothelia
... Materials and Methods: The expression of chemokine receptors in human brain microvascular endothelial cells (BMVEC) and coronary artery endothelial cells (CAEC).. in vitro and cryostat s[r] ...
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Delivery of stromal cell-derived factor 1α for in situ tissue regeneration
... control chemokine release with time-specific, site- specific and rate programmed characteristics, some environmental stimuli-responsive microcapsules have been researched ...
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